Non-isotope enriched phenylboronic acid-decorated dual-functional nano-assembles for an actively targeting BNCT drug

Kim, Ahram; Suzuki, Minoru; Matsumoto, Yoshitaka; Fukumitsu, Nobuyoshi; Nagasaki, Yukio

doi:10.1016/j.biomaterials.2020.120551

Cited by 31 publications

(28 citation statements)

References 53 publications

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“…In an experiment using tumor-bearing mice, PM micelles reached 14 ppm after 24 h of administration, and the tumors disappeared in two out of five mice after 25 days of thermal neutron irradiation. More recently, a collaboration between our group and the Nagasaki laboratory has led to the development of PBA-modified polymeric nanoparticles (Nano PBA ) with sialic acid orientation as a boron preparation that has different targeting properties from LAT1 and can maintain 10 B levels in tumors for a long time [ 214 ]. Nano PBA has a supramolecular structure consisting of a core and shell composed of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) segments ( Figure 7 ).…”

Section: Relationship Between Boron Neutron Capture Therapy (Bnct) and Boron Compoundsmentioning

confidence: 99%

A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

Matsumoto

Fukumitsu²,

Ishikawa

et al. 2021

JPM

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In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years—in multidisciplinary treatment. Three types of particle therapies are currently used for cancer treatment: proton beam therapy (PBT), carbon-ion beam therapy (CIBT), and boron neutron capture therapy (BNCT). PBT and CIBT have been reported to have excellent therapeutic results owing to the physical characteristics of their Bragg peaks. Variable drug therapies, such as chemotherapy, hormone therapy, and immunotherapy, are combined in various treatment strategies, and treatment effects have been improved. BNCT has a high dose concentration for cancer in terms of nuclear reactions with boron. BNCT is a next-generation RT that can achieve cancer cell-selective therapeutic effects, and its effectiveness strongly depends on the selective 10B accumulation in cancer cells by concomitant boron preparation. Therefore, drug delivery research, including nanoparticles, is highly desirable. In this review, we introduce both clinical and basic aspects of particle beam therapy from the perspective of multidisciplinary treatment, which is expected to expand further in the future.

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Section: Relationship Between Boron Neutron Capture Therapy (Bnct) and Boron Compoundsmentioning

confidence: 99%

A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

Matsumoto

Fukumitsu²,

Ishikawa

et al. 2021

JPM

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“…The boron-containing peptides and linear conjugated bonds with boron captate have been studied. Phenylboronic acid-enhanced its functionalities, i.e., containing a capacity to capture a neutron toward itself and highly erect the activated BNCT drugs and kill the malignant cells within a particular range [32] 5.2. Boron containing Thymidine 3-Carboranyl thymidine analogs (3CTAs) are compounds of Boron-containing purines, Pyrimidine, thymidine.…”

Section: Boron Containing Amino Acidmentioning

confidence: 99%

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

Namdev

Kaur

2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Nowadays, Cancer is undoubtedly a consequential and potentially life-threatening illness. In the U.S., Around 1.7 million people discerned with Cancer last year. The application of boron in cancer treatment is applicable as therapy known as Boron Neutron Capture Therapy (BNCT). It is an analeptic technique that depends on the nuclear capture and fission reaction that results in various particles such as Li, He nuclei with their kinetic energy and γ-radiation. These radiations kill the malignant cells in our body without damaging the normal tissue. Boron particles delivered selectively to only malignant cells by minimizing their concentration in normal cells. In this article, The clinical trials, clinical investigation in Different countries with a different type of Cancer as Lung, Brain, Head/Neck, Hepatic and gastrointestinal. Various delivery methods of Boron agents in the tumor cells recently developed boron delivery agents, and different techniques of their dose distribution explain. In recent years, boron compounds were applied with porphyrin, copolymers, nanoparticles, other peptides, EGRF’s, and Liposomes to intensify their killer properties toward target cancer cells. BNCT is also effectively used for the medication of various kinds of Cancers explained. The purpose of this article is to indicate the intelligible way of BNCT(Reactor-Based) for the treatment of malignant cells.

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“…12 Nagasaki and coworkers reported a PBA-decorated polymeric nanoparticle that is effective against a B16 melanoma-bearing mice model. 24 Among the nanomaterials used against cancer, a new class of material has recently emerged and is showing promising results, that is, the carbon dots (C-dots). [25][26][27] C-dots are spheroidal nanoparticles with sizes typically smaller than 10 nm, composed by a graphitic core and covered by an amorphous carbonaceous edge.…”

Section: Introductionmentioning

confidence: 99%

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

et al. 2021

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Non-isotope enriched phenylboronic acid-decorated dual-functional nano-assembles for an actively targeting BNCT drug

Cited by 31 publications

References 53 publications

A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

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