Non-Ischemic Heart Failure With Reduced Ejection Fraction Is Associated With Altered Intestinal Microbiota

Katsimichas, Themistoklis; Ohtani, Tomohito; Motooka, Daisuke; Tsukamoto, Yasumasa; Kioka, Hidetaka; Nakamoto, Kei; Konishi, Shozo; Chimura, Misato; Sengoku, Kaoruko; Mikami, Hiroshi; Sakaguchi, Taiki; Okumura, Ryu; Theofilis, Konstantinos; Iida, Tetsuya; Takeda, Kiyoshi; Nakamura, Shota; Sakata, Yasushi

doi:10.1253/circj.cj-17-1285

Cited by 48 publications

(31 citation statements)

References 36 publications

(37 reference statements)

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“…The preponderance of genera belonging to Proteobacteria in control subjects and of the genera Streptococcus and Dorea in AF were similar to our results. It is noteworthy that patients with AF shared the enrichment of numerous microbial flora, such as Streptococcus and Dorea, demonstrated in hypertension [36], heart failure [37], and CAD [4]. An excess of these genera agrees with a recent study showing that overgrowth of genera is related to plasma and fecal indole [20].…”

Section: Discussionsupporting

confidence: 86%

“…However, there is no evidence to date linking the relationship between hemodynamics and gut microbiota. The relationship between the gut microbiota and heart failure, in which cardiac output may be reduced, has been reported [9,37]. However, the results of those studies were contrasting, and the specific gut microbial phenotype of heart failure remains controversial.…”

Section: Discussionmentioning

confidence: 99%

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Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs

et al. 2020

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Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level, Enterobacter was depleted, while Parabacteroides, Lachnoclostridium, Streptococcus, and Alistipes were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs

et al. 2020

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“…In the wild, due to food shortage, protein and fat intake decreased, and the Bacteroidetes content increased to help host to increase their nutrition. A disruption of the symbiosis between the microbiota and host is known as dysbiosis and is described in multiple chronic diseases, such as obesity and malnutrition (Castaner et al 2018;Zhang et al 2018;Jeong et al 2019), neurological disorders (Kurokawa et al 2018;Quagliariello et al 2018;Sun and Shen 2018), inflammatory bowel disease (IBD) (Costa et al 2012;Roche-Lima et al 2018), metabolic syndrome (Zhao et al 2018), cancer and other diseases (Katsimichas et al 2018;Lu et al 2018;Panebianco et al 2018;Pulikkan et al 2018;Zitvogel et al 2018). We presume that the health of the wild group of Tibetan wild asses was better than the captive group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the gut microbiota composition between the wild and captive Tibetan wild ass ( Equus kiang )

et al. 2019

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Aims The gut microbiota has a great effect on the health and nutrition of the host. Manipulation of the intestinal microbiota may improve animal health and growth performance. The objectives of our study were to characterize the faecal microbiota between wild and captive Tibetan wild asses and discuss the differences and their reasons. Methods and Results Through high‐throughput sequencing of the 16S rRNA V4‐V5 region, we studied the gut microbiota composition and structure of Tibetan wild asses in winter, and analysed the differences between wild and captive groups. The results showed that the most common bacterial phylum in Tibetan wild ass faeces samples was Bacteroidetes, while the phylum Firmicutes was dominant in captive Tibetan wild ass faecal samples. The relative abundance of Firmicutes, Tenericutes and Spirochaetes were significantly higher (P < 0·01) than in the wild groups. Conclusions Captivity reduces intestinal microbial diversity, evenness and operational taxonomic unit number due to the consumption of industrial food, therefore, increasing the risk of disease prevalence and affecting the health of wildlife. Significance and Impact of the Study We studied the effect of the captive environment on intestinal micro‐organisms. This article provides a theoretical basis for the ex‐situ conservation of wild animals in the future.

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“…It also negatively impacts upon the immune system [ 20 ], the cardiovascular system [ 21 ], the brain, and behaviour [ 22 ]. There have been a considerable number of reports in recent years demonstrating that the composition of the microbiome can significantly impact not only an individual’s risk of systemic disease [ 22 , 23 , 24 ], but also the extent of disease progression [ 25 , 26 , 27 , 28 ]. It has been demonstrated that modulating the microbial composition may be a promising therapeutic avenue [ 29 ] for cancer [ 30 ], auto-immune [ 31 , 32 ], cardiovascular and kidney diseases [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

et al. 2018

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Accumulating evidence demonstrates that dietary supplementation with functional food ingredients play a role in systemic and brain health as well as in healthy ageing. Conversely, deficiencies in calcium and magnesium as a result of the increasing prevalence of a high fat/high sugar “Western diet” have been associated with health problems such as obesity, inflammatory bowel diseases, and cardiovascular diseases, as well as metabolic, immune, and psychiatric disorders. It is now recognized that modulating the diversity of gut microbiota, the population of intestinal bacteria, through dietary intervention can significantly impact upon gut health as well as systemic and brain health. In the current study, we show that supplementation with a seaweed and seawater-derived functional food ingredient rich in bioactive calcium and magnesium (0.1% supplementation) as well as 70 other trace elements, significantly enhanced the gut microbial diversity in adult male rats. Given the significant impact of gut microbiota on health, these results position this marine multi-mineral blend (MMB) as a promising digestive-health promoting functional food ingredient.

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Non-Ischemic Heart Failure With Reduced Ejection Fraction Is Associated With Altered Intestinal Microbiota

Abstract: Non-ischemic HFrEF patients exhibited multidimensional differences in intestinal microbial communities compared with healthy subjects.

Cited by 48 publications

References 36 publications

Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs

Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs

Comparison of the gut microbiota composition between the wild and captive Tibetan wild ass ( Equus kiang )

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

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