Non-invasive ultrasound detection of endothelial dysfunction

Atkov, O.Yu.; Balahonova, T.V.; Pogorelova, O.

doi:10.1016/s0929-8266(98)00009-3

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…Present study indicates endothelial dysfunction in all the patients of both the groups (FMD% in Study gr: 7.37%, Control gr: 7.50%, Normal: is ≥18.5%) which is similar to previous studies of Kelm M, et al, Iiyama et al, Li J et al, Hunan et al and Atkov et al [9][10][11][12][13] The pathogenesis for endothelial dysfunction in hypertensive patients is due to;…”

Section: Non-lipid Effects Of Statins: On Endothelial Functionsupporting

confidence: 90%

Study of lipid and non-lipid effects of statins in hypertensive patients

Shashikala

Rao

2016

Int J Basic Clin Pharmacol

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INTRODUCTIONHypertension is one of the most important public health problems worldwide and if left untreated, 50% die of CAD, 33% die of stroke and 10-15% die of renal failure. 1 These vascular complications of the Hypertension are mainly due to the damage to vascular endothelium (endothelial dysfunction) caused by shear stress of Hypertension which is the initial event in atherosclerotic process. Hence the present study is aimed at observing the association of the essential hypertension with endothelial dysfunction and left ventricular dysfunction which are assessed noninvasively and to evaluate the effects of statins (non-lipid effects) on endothelial and left ventricular dysfunction besides their conventional effect on lipid profile. METHODSHypertensive is diagnosed when SBP is ≥140 mm Hg and or DBP is ≥90mm Hg as per JNC-VII criteria, 2003. 2 Patients with Secondary hypertension, Diabetes mellitus, Hyperlipidemia, Ischemic heart disease and history of smoking were excluded from the study. ABSTRACTBackground: Hypertension is one of the commonest diseases affecting the mankind which is associated with endothelial dysfunction and left ventricular dysfunction and hence the study is aimed to observe the effects of statins on endothelial and left ventricular dysfunction. Methods: 15 hypertensive patients were given atorvastatin for 4 weeks and compared with sex and aged matched 15 controls after a detailed Clinical history, clinical examination, biochemical investigations, chest X-ray, electrocardiogram, echocardiogram and Doppler study of brachial artery. Results: Both study group and control group consisted of 10 males and 5 females who have dyslipidemia, endothelial and ventricular dysfunction. After a 4 weeks of study, in study group, flow mediated brachial artery diameter (FMD%) increased significantly (11.39%, P<0.01) from 7.37% to 18.76%, mean LV systolic function (EF) improved significantly (10.73%, P:<0.01) from 54.6% to 60.65%, LV diastolic function was normalized in 7 (46.67%) and improved in 5 (33.33%) patients, the mean systolic and diastolic BP decreased significantly (12.03%, P<0.01, 10.29%, P<0.01) from 149.66mmHg to 131.66mmHg and from 90.66mmHg to 81.33mmHg respectively, while in control group FMD increased marginally (1.07%) from 7.50% to 8.57%, LV EF marginally improved (1.47%) to 54.86% from 54.06%; no improvement in diastolic dysfunction, mean systolic and diastolic BP decreased marginally (6.25%, 0.74%) from 149.33 mmHg to 140mmHg and from 90.33mmHg to 89.66mmHg respectively. Conclusions: Statins improve not only lipid profile but also endothelial and LV functions which resulted in significant reduction of systolic and diastolic BP. Hence it is reasonable to treat all hypertensive patients with statins besides concurrent hypertension treatment.

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Section: Non-lipid Effects Of Statins: On Endothelial Functionsupporting

confidence: 90%

Study of lipid and non-lipid effects of statins in hypertensive patients

Shashikala

Rao

2016

Int J Basic Clin Pharmacol

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“…260 NED dilation is less strongly related to cardiovascular risk factors, with independent associations found only with age, baseline diameter, 231 and BMI. 261 NED dilation is not impaired in patients with FH, essential hypertension, 262 or inflammatory periodontal disease, 234 which suggests that endothelium-dependent mechanisms may be more important in assessing cardiovascular risk than the biological processes that affect smooth muscle in the arterial wall. NED vasodilation does not appear to be affected by hydroxymethylglutaryl-coenzyme A reductase inhibitor therapy 254 or treatment with antihypertensive agents.…”

Section: Relationship To Cardiovascular Risk In Adultsmentioning

confidence: 99%

“…De Jongh et al, 252 Mietus-Snyder and Malloy, 267 Aggoun et al, 39 Sorensen et al, 268 Tounian et al 171 Atkov et al,* 262 Aggoun et al,* 39 Jä rvisalo et al 269 Family history of CVD or risk factors Gaeta et al 59 …”

Section: Dyslipidemiamentioning

confidence: 99%

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

Urbina

Williams²,

Alpert³

et al. 2009

Hypertension

552

274

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Abstract-Deterioration in endothelial function and arterial stiffness are early events in the development of cardiovascular diseases. In adults, noninvasive measures of atherosclerosis have become established as valid and reliable tools for refining cardiovascular risk to target individuals who need early intervention. With limited pediatric data, the use of these techniques in children and adolescents largely has been reserved for research purposes. Therefore, this scientific statement was written to (1) review the current literature on the noninvasive assessment of atherosclerosis in children and adolescents, (2) make recommendations for the standardization of these tools for research, and (3) stimulate further research with a goal of developing valid and reliable techniques with normative data for noninvasive clinical evaluation of atherosclerosis in pediatric patients. Precise and reliable noninvasive tests for atherosclerosis in youth will improve our ability to estimate future risk for heart attack and stroke. Currently, large longitudinal studies of cardiovascular risk factors in youth, such as the Bogalusa and Muscatine studies, lack sufficient adult subjects experiencing hard outcomes, such as heart attack and stroke, to produce meaningful risk scores like those developed from Framingham data.

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“…2 детей с гомозиготной формой СГХС, было показано, что эндотелий-зависимая вазодилатация (ЭЗВД) у больных СГХС снижена, в то время как эндотелий-независимая вазодилатация (ЭНВД) не была изменена [8]. Подобные результаты были получены и в работе [5]. Именно снижение ЭЗВД в отличие от ЭНВД в большинстве исследований ассоциировано с повышенным риском ИБС [60].…”

Section: количественное исследование гетерогенности аб в двухмерном рunclassified

Modern ultrasound methods and atherosclerosis assessment in patients with familial hypercholesterolemia

Ершова

Мешков

Бойцов

et al. 2011

Cardiovasc Ther Prev

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Familial hypercholesterolemia (FHCH) is characterised by early atherosclerosis development and its fast progression. The prevalence of FHCH inRussiahas been increasing, therefore, it is important to evaluate the potential of various methods for atherosclerosis diagnostics. Arterial ultrasound is an informative, accessible, and safe method for evaluating atherosclerotic vascular changes. The modern ultrasound methods allow describing vascular wall status in detail, including qualitative and quantitative characteristics of its structure and function. At the same time, most ultrasound characteristics of arterial wall are used in research settings or are under development, and not implemented into clinical practice. The most promising parameters, applicable for clinical use in FHCH patients, simultaneously describe atherosclerosis severity and its localization, such as total plaque height, ankle-brachial index, and plaque number.

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Non-invasive ultrasound detection of endothelial dysfunction

Cited by 11 publications

References 20 publications

Study of lipid and non-lipid effects of statins in hypertensive patients

Study of lipid and non-lipid effects of statins in hypertensive patients

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

Modern ultrasound methods and atherosclerosis assessment in patients with familial hypercholesterolemia

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