Non-invasive transcranial ultrasound stimulation for neuromodulation

Darmani, Ghazaleh; Bergmann, Til Ole; Pauly, Kim Butts; Caskey, Charles F.; Lecea, Luı́s de; Fomenko, Anton; Fouragnan, Elsa; Legon, Wynn; Murphy, Keith R.; Nandi, Tulika; Phipps, M. Anthony; Pinton, Gianmarco; Ramezanpour, Hamidreza; Sallet, Jérôme; Yaakub, Siti N.; Yoo, Seung Schik; Chen, R.

doi:10.1016/j.clinph.2021.12.010

Cited by 127 publications

(103 citation statements)

References 227 publications

(363 reference statements)

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“…Recently, several studies reported other protocols to induce sustained excitability changes, such as 15-min stimulation (Zhang et al, 2021) and 80-s theta-burst stimulation (Zeng et al, 2022). Modulation of neuronal activity via TUS is considered to be caused by a transient mechanical perturbation of the cell membrane, changing the permeability of ion channels (Darmani et al, 2022;Pasquinelli et al, 2019). The precise neural mechanism of TUS modulation, however, requires further investigation.…”

Section: Technical Considerations For Ultrasound Stimulationmentioning

confidence: 99%

“…In the present study, low-intensity transcranial ultrasound stimulation (TUS) was used to perform interventions in the human basal ganglia. TUS can noninvasively stimulate the deep brain structures with high spatial accuracy of a few millimeters (Cain et al, 2021;Darmani et al, 2022;Folloni et al, 2019;Fomenko et al, 2018;Fouragnan et al, 2019;Kubanek et al, 2020;Legon et al, 2014;Pasquinelli et al, 2019). Previous studies have reported that TUS can induce short-or long-term suppression/enhancement of the activity depending on stimulation protocols (Fomenko et al, 2020;Legon et al, 2018;Verhagen et al, 2019;Zeng et al, 2022;Zhang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

Nakajima

Osada²,

Ogawa³

et al. 2022

Cell Reports

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Section: Technical Considerations For Ultrasound Stimulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

Nakajima

Osada²,

Ogawa³

et al. 2022

Cell Reports

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“…The stability of the ssVEP creates a novel opportunity for within-participant studies of neuroplasticity in relatively small numbers of participants, including repetitive sensory neuroplasticity processes (Cooke and Bear, 2010; Kirk et al, 2010) and repetitive brain stimulation-induced neuroplasticity (Thut and Pascual-Leone, 2010; Darmani et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Stability of steady-state visual evoked potential contrast response functions

Ash

Nix

Norcia

2022

Preprint

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A repeated measure of neural activity that is stable over time when unperturbed is needed to be able to meaningfully measure neuroplastic changes in the brain. With sensory-evoked potentials in particular, repeated presentation of stimuli can generate neuroplasticity by itself under certain conditions. We assessed the repeated-measure within-day and across-day stability of the steady-state visual-evoked potential (ssVEP), a high signal-to-noise electrophysiological readout of neural activity in human visual cortex, in preparation for studies of visual cortical neuroplasticity. Steady-state VEP contrast-sweep responses were measured daily for 4 days (four 20-trial blocks per day, 22 participants). Response amplitudes were stable in individual participants, with measured across-block and across-day coefficients of variation (CV= SD / Mean) of 12±1% and 19±2%, respectively. No consistent changes in response amplitude were observed either across blocks or across days. We conclude that contrast-sweep steady-state VEPs provide a stable human neurophysiological measure well-suited for repeated-measures studies.

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“…Similarly, the delivery of tES on the frontal areas may have the potential to improve symptoms in psychiatric diseases like OCD ( D’Urso et al, 2016 ) and eating disorders ( Mattavelli et al, 2019 ) or neurodevelopmental disorders like ADHD (see Salehinejad et al, 2020 for a recent review). Finally, emerging NIBS techniques, like the transcranial Focal Ultrasound Stimulation (tFUS; Darmani et al, 2022 ) may provide innovative protocols for non-invasive neuromodulation of cortical and subcortical brain structures. In fact, using ultrasonic mechanical waves at low frequencies, tFUS can reach deep brain structures with a very high spatial resolution causing changes in neuronal excitability without damaging the stimulated tissues.…”

Section: Final Remarks and Future Directionsmentioning

confidence: 99%

Neuromodulating the performance monitoring network during conflict and error processing in healthy populations: Insights from transcranial electric stimulation studies

Fusco

Cristiano

Perazzini

et al. 2022

Front. Integr. Neurosci.

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The performance monitoring system is fundamentally important for adapting one’s own behavior in conflicting and error-prone, highly demanding circumstances. Flexible behavior requires that neuronal populations optimize information processing through efficient multi-scale communication. Non-invasive brain stimulation (NIBS) studies using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) fields to alter the cortical activity promise to illuminate the neurophysiological mechanisms that underpin neuro-cognitive and behavioral processing and their causal relationship. Here, we focus on the transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) that have been increasingly used in cognitive neuroscience for modulating superficial neural networks in a polarity (tDCS) and frequency/phase (tACS) fashion. Specifically, we discuss recent evidence showing how tDCS and tACS modulate the performance monitoring network in neurotypical samples. Emphasis is given to studies using behavioral tasks tapping conflict and error processing such as the Stroop, the Flanker, and the Simon tasks. The crucial role of mid-frontal brain regions (such as the medial frontal cortex, MFC; and the dorsal anterior cingulate cortex, dACC) and of theta synchronization in monitoring conflict and error is highlighted. We also discuss current technological limitations (e.g., spatial resolution) and the specific methodological strategies needed to properly modulate the cortical and subcortical regions.

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Non-invasive transcranial ultrasound stimulation for neuromodulation

Cited by 127 publications

References 227 publications

A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

Stability of steady-state visual evoked potential contrast response functions

Neuromodulating the performance monitoring network during conflict and error processing in healthy populations: Insights from transcranial electric stimulation studies

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