Non-invasive transabdominal measurement of placental oxygenation: a step toward continuous monitoring

Nguyen, Thien; Khaksari, Kosar; Khare, Siddharth; Park, Soongho; Anderson, Afrouz; Bieda, Janine; Jung, Eun-Jung; Hsu, Chaur‐Dong; Romero, Roberto; Gandjbakhche, Amir

doi:10.1364/boe.424969

Cited by 8 publications

(7 citation statements)

References 46 publications

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“…Nine studies described the application of wearable sensors to collect information about foetal parameters [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. These studies are described in Table 1 , together with a summary of their design and population, wearable device used, and main findings.…”

Section: Resultsmentioning

confidence: 99%

“…The remaining study included in this section used a near-infrared spectroscopy device to evaluate placental oxygenation, a good indicator of placental structure and function. Nguyen and colleagues, in fact, developed a near-infrared spectroscopy device for the non-invasive transabdominal measurement of placental oxygenation [ 18 ]. The device was not just valid to measure placental oxygenation, but it was also useful to demonstrate lower placental oxygenation level in women with a complicated pregnancy [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…Nguyen and colleagues, in fact, developed a near-infrared spectroscopy device for the non-invasive transabdominal measurement of placental oxygenation [ 18 ]. The device was not just valid to measure placental oxygenation, but it was also useful to demonstrate lower placental oxygenation level in women with a complicated pregnancy [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

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How Wearable Sensors Can Support the Research on Foetal and Pregnancy Outcomes: A Scoping Review

Maugeri

Barchitta

Agodi

2023

JPM

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The application of innovative technologies, and in particular of wearable devices, can potentially transform the field of antenatal care with the aim of improving maternal and new-born health through a personalized approach. The present study undertakes a scoping review to systematically map the literature about the use wearable sensors in the research of foetal and pregnancy outcomes. Online databases were used to identify papers published between 2000–2022, from which we selected 30 studies: 9 on foetal outcomes and 21 on maternal outcomes. Included studies focused primarily on the use of wearable devices for monitoring foetal vital signs (e.g., foetal heart rate and movements) and maternal activity during pregnancy (e.g., sleep patterns and physical activity levels). There were many studies that focused on development and/or validation of wearable devices, even if often they included a limited number of pregnant women without pregnancy complications. Although their findings support the potential adoption of wearable devices for both antenatal care and research, there is still insufficient evidence to design effective interventions. Therefore, high quality research is needed to determine which and how wearable devices could support antenatal care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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How Wearable Sensors Can Support the Research on Foetal and Pregnancy Outcomes: A Scoping Review

Maugeri

Barchitta

Agodi

2023

JPM

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“…Due to its critical role in maintaining organ function, StO 2 has been frequently used to monitor patient health. Common sites to measure StO 2 include the brain [6], spinal cord [7,8], peripheral muscle [9], leg [10], kidney [11,12], and placenta [13].…”

Section: Introductionmentioning

confidence: 99%

“…Current techniques to evaluate the oxygenation level in a tissue include invasive methods, such as Clark-type electrodes [14], electron spin resonance probes [15], and fiber optic probes with phosphorescent dyes [16], and noninvasive methods, such as magnetic resonance imaging (MRI) [17], positron emission tomography (PET) [18], and near-infrared spectroscopy (NIRS) [6,13,19]. While invasive methods provide a direct measurement of the oxygenation level with high accuracy, they are more resource intensive and may create new pathways for infections [20].…”

Section: Introductionmentioning

confidence: 99%

Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation Using Continuous Wave Near-Infrared Spectroscopy

Nguyen

Park

Hill

et al. 2023

IEEE Open J. Eng. Med. Biol.

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Currently, common optical techniques to measure tissue oxygen saturation (StO 2 ) include time domain (TD), frequency domain (FD), and continuous wave (CW) near-infrared spectroscopy (NIRS). While TD-and FD-NIRS can provide absolute hemoglobin concentration, these systems are often complex and expensive. CW-NIRS, such as diffuse reflectance spectroscopy and spatially resolved spectroscopy (SRS), are simpler and more affordable, but they still require at least two sourcedetector separations. Here, we propose a single source-detector separation (SSDS) approach to measure StO 2 using reflected intensities from three wavelengths. The accuracy of the SSDS-based StO 2 measurement was verified using an optical simulation and an in-vivo experiment. Simulated spatially dependent reflectance was generated using the Virtual Tissue Simulator on a 1layer model, which has StO 2 ranging from 0% to 100%. SSDS calculation yielded an equivalent StO 2 to the actual value (average error = 0.3% ± 0.5%). We then performed StO 2 measurements on seven healthy volunteers in the prefrontal cortex during a simulated hypercapnia test using a CW-NIRS device. This device consists of a light source and two photodetectors, which are 30 mm and 40 mm away from the light source. The cerebral oxygen saturation was calculated using both the SRS approach, which uses the reflected intensities at both separations, and the SSDS approach, which employs the reflected intensities at either 30 mm or 40 mm separation. The SRS-based StO 2 calculation was similar to the value calculated from the SSDS method (average difference = 5.0% ± 1.1%). This proposed method will help to advance the development of miniaturized technologies to monitor StO 2 continuously. StO2, multiwavelength, wearable, IMPACT STATEMENT A novel avenue to measure tissue oxygen saturation noninvasively with high accuracy using a multiwavelength LED and a photodetector was developed and verified with an optical simulation and in-vivo experiment. INDEX TERMS

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Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging

Wang

Cochran

et al. 2022

Nat. Biomed. Eng

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Direct assessment of human placental blood oxygenation can provide valuable information about placental function and, potentially, detect dysfunction. Currently however, no bedside tools exist for noninvasive monitoring of placental oxygenation. Here we report a continuous, non-invasive in vivo method to probe placental oxygen hemodynamics using deep penetrating Frequency Domain Diffuse Optical Spectroscopy (FD-DOS) with concurrent ultrasound (US) imaging. This multi-modal instrument facilitates assessment of placental oxygenation properties from image reconstruction algorithms that integrate anatomical US information about layer morphology with information from optics about functional hemodynamics. Tissue phantom experiments, simulations, and human subject studies validate the approach and demonstrate sensitivity to placental tissue located  5 cm below the surface. In a pilot study (n=24), human placental oxygen hemodynamics are measured non-invasively during maternal hyperoxia. Initial results suggest placental response to maternal hyperoxia may serve as a tool to detect placenta-related adverse pregnancy outcome and maternal vascular malperfusion of placenta, weeks before delivery.Abnormal placental development is widely accepted as the cause of common adverse pregnancy outcomes (APOs) such as hypertensive disorders, fetal growth restriction, and stillbirth. Moreover, placental dysfunction has been associated with morbidities in offspring, including perinatal mortality and long-term neurodevelopmental and cardiovascular consequences 1-3 . To better understand human placental dysfunction associated with these APOs, non-invasive methods that measure placental oxygen dynamics are needed. Ultrasound (US) imaging is the primary clinical modality used for assessing pregnancy; it can provide indirect information about flow resistance in large blood vessels but is used primarily to derive morphological information. Thus, clinical US guidelines do not include direct functional assessment of the placenta 4 . Current knowledge about placental biology has been gleaned largely from ex-vivo tissue and from animal research 5,6 , which have limitations as models for dynamic changes in placental pathophysiology during pregnancy 7,8 . Similarly, the reference literature on placental oxygenation is derived largely from decades-old sheep studies, and from scant human data using invasive sampling techniques that have yielded varying results 7,9 . Lastly, even MRI tools for assessing placental oxygenation 10,11 are poorly suited for bedside monitoring and generally rely on indirect signals 12 .

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Non-invasive transabdominal measurement of placental oxygenation: a step toward continuous monitoring

Cited by 8 publications

References 46 publications

How Wearable Sensors Can Support the Research on Foetal and Pregnancy Outcomes: A Scoping Review

How Wearable Sensors Can Support the Research on Foetal and Pregnancy Outcomes: A Scoping Review

Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation Using Continuous Wave Near-Infrared Spectroscopy

Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging

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