Non-invasive techniques for the diagnosis of Helicobacter pylori infection

Gatta, Luigi; Ricci, Chiara; Tampieri, Andrea; Vaira, Dino

doi:10.1046/j.1469-0691.2003.00707.x

Cited by 41 publications

(38 citation statements)

References 33 publications

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“…The urea breath test and the stool antigen test are accurate non-invasive tests with sensitivity and specificity rates up to 93-95% each [27,28] . The value of non-invasive testing depends on the positive and negative predictive value, which is related to H. pylori prevalence in the tested population.…”

Section: Test and Treat H Pylori In Uninvestigated Dyspepsiamentioning

confidence: 99%

Dyspepsia and <i>Helicobacter pylori</i>

Selgrad

Kandulski

Malfertheiner³

2008

Dig Dis

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Dyspepsia is defined as a chronic or recurrent pain centered in the upper abdomen. Dyspeptic symptoms have a high prevalence in the population and represent a common reason for patients to see a primary care physician. Therefore, dyspepsia displays a major health care burden and produces high socioeconomic costs. The etiology of dyspeptic symptoms is various and complex and has opened a wide spectrum of putative mechanisms. In a subset of patients dyspeptic symptoms are likely to originate from Helicobacter pylori infection. Population-based studies have demonstrated that H. pylori is detected more frequently in dyspeptic patients compared to controls. H. pylori eradication therapy gives modest but significant benefit in non-ulcer dyspepsia and leads to long-term symptom improvement. It also reduces the risk of developing peptic ulcer disease and other H. pylori-related gastric pathologies (i.e. atrophic gastritis, gastric cancer). The main therapeutic strategy for managing dyspepsia in patients under the age of 45 years is ‘test and treat’. H. pylori eradication is recommended in patients with dyspepsia and no other gastroduodenal abnormalities than H. pylori induced gastritis. In patients presenting with alarm features a prompt upper endoscopy should be performed to exclude peptic ulcer disease, esophageal and gastric malignancies or other more rare upper gastrointestinal diseases.

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Section: Test and Treat H Pylori In Uninvestigated Dyspepsiamentioning

confidence: 99%

Dyspepsia and <i>Helicobacter pylori</i>

Selgrad

Kandulski

Malfertheiner³

2008

Dig Dis

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“…detection of anti-H. pylori IgG antibodies through ELISA) or stool (e.g. H. pylori stool antigen; HpSA test), have been developed and efficiently used in diagnosis of H. pylori infection (20). It was reported that noninvasive tests such as 13C-UBT, H. pylori stool antigen and anti-H. pylori immunoglobulin G antibody are relatively concordant and specific for the diagnosis of H. pylori infection (21,22).…”

Section: Discussionmentioning

confidence: 99%

Potential Complications of Helicobacter pylori Infection in Children of a Non-Urban Community

Ali

Elkhatib

2015

Arch Pediatr Infect Dis

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Background:Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections world-wide and has several adverse consequences particularly on health of pediatric patients. Objectives: The current study addressed various clinical presentations associated with H. pylori infections among children of a rural community. Materials and Methods:In this case-control study, the number of cases (H. pylori-positive) were 120 (52.5% boys and 47.5% girls) and the control group (H. pylori-negative) were 100 cases aged 7 -12 years old (Mean 9.9 ± 3 years). H. pylori infection was defined by positive results for H. pylori stool antigen test and serum IgG or urea breath test. All pediatric participants were assessed for weight, height, sideropenic anemia and gastrointestinal symptoms. Results:The results showed that recurrent abdominal pain, recurrent vomiting and anorexia were 81 (67.5%), 24 (20%) and 15 (12.5%), respectively in H. pylori-infected patients, compared to 28 (28%), 8 (8%) and 4 (4%) in control group. Weight and height were 20.4 ± 1 kg and 128.1 ± 1 cm in case group compared to 25.6 ± 1.7 kg and 133.8 ± 2 cm in control group. Sideropenic anemia was 36.7% in patients compared to 15% in control. Conclusions: In conclusion, the study findings revealed that pediatric H. pylori infection is associated with recurrent abdominal pain, anorexia and recurrent vomiting, also adversely affects the growth of children in various modalities; in particular weight, height and progressive incidence of sideropenic anemia.

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“…The cost of applying red phenol over the gastric mucosa does not differ from that of the urease test and has as advantage that it allows the survey of the mucosa so as to direct the taking of samples, it avoids false positives and/or negatives related with the contamination due to manipulation of samples, temperature, conservation and reading of the same (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Chromoendoscopy with red phenol in the diagnosis of Helicobacter pylori infection

Hernández‐Garcés¹,

Castellanos-González²,

González-Fabián

et al. 2012

Rev. esp. enferm. dig.

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An analytic study to validate a diagnostic test was carried out at the Institute of Gastroenterology in Havana, Cuba in adult patients of both sexes in whom chromoendoscopy was carried out with red phenol at 0.1% over the gastric mucosa for the detection of Helicobacter pylori infection between November 2008 and December 2010. The staining with red phenol at 0.1% is included in the invasive tests for the diagnosis of Helicobacter pylori infection and of the reactive techniques. The sensibility of red phenol dye in the diagnosis of Helicobacter pylori infection in the patients studied was of 72.6% with a confidence interval (C.I.) of 95% (64.9 to 79.2%) and a specificity of 75.5% C.I. 95% (61.9 to 85.4%). The positive predictive value was of 89.8% C.I. 95% (83.1 to 94.1%) and the negative predictive value of 48.1% C.I. 95% (37.3 to 59.0%). The proportion of false positives was of 24.5% C.I. 95% (14.6 to 38.1%) and the proportion of false negatives was of 27.4% C.I. 95% (20.8 to 35.1%). The diagnostic accuracy of the dye on the patients studied was 73.3% C.I. 95% (66.7 to 79.0%). The diagnostic odds ratio was 8.17 C.I. 95% (3.88 to 17.23), the J Youden ratio of 0.5 and the Kappa coefficient of 0.40 C.I. 95% (0.27 to 0.54). The staining dye with red phenol at 0.1% resulted in a useful method in the diagnosis of Helicobacter pylori infection in the gastric mucosa, it can be applied in our environment and has multiple advantages (topographic localization, avoids contamination and fast and immediate reading).

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Non-invasive techniques for the diagnosis of Helicobacter pylori infection

Cited by 41 publications

References 33 publications

Dyspepsia and <i>Helicobacter pylori</i>

Dyspepsia and <i>Helicobacter pylori</i>

Potential Complications of Helicobacter pylori Infection in Children of a Non-Urban Community

Chromoendoscopy with red phenol in the diagnosis of Helicobacter pylori infection

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