Non-invasive stimulation of vagal afferents reduces gastric frequency

Teckentrup, Vanessa; Neubert, Sandra; Santiago, João; Hallschmid, Manfred; Walter, Martin; Kroemer, Nils B.

doi:10.1101/773259

Cited by 1 publication

(3 citation statements)

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“…Likewise, taVNS may enhance sensitivity to interoceptive signals 12,17 contributing to effortful behavior and the subjective evaluation of costs and benefits of action 16,81,82 .…”

Section: Discussionmentioning

confidence: 99%

“…Then, the stimulation electrode of the NEMOS® tVNS device (cerbomed GmbH, Erlangen, Germany) was attached and secured with surgical tape on the right ear, either at the cymba conchae for taVNS or at the ear lobe for sham. For each session, we individually adjusted the stimulation amplitude by slowly increasing it in 0.1-0.2 mA steps until the participants' sensation (assessed with VAS) was rated as a "mild pricking" and below the pain threshold 16,60,61 . The stimulation then continued according to the default protocol (i.e., alternating 30 s phases of stimulation with biphasic impulse frequency of 25 Hz and 30 s pauses).…”

Section: Methodsmentioning

confidence: 99%

“…The required communication between peripheral organs and the brain is channeled through the vagus nerve and converges on the nucleus of the solitary tract in the brainstem to modulate motivational circuits 10 . Consequently, vagal afferents tune motivated behavior 11,12 such as food seeking 13,14 and response vigor 15 . While preliminary evidence has shown the potential of transcutaneous vagus nerve stimulation (taVNS) to affect motivated behavior and brain-body signaling in healthy participants 16,17 , its potential for improving motivational deficits in MDD has not yet been established.…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression

Ferstl,

Kühnel,

Klaus

et al. 2023

Preprint

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BackgroundMajor depressive disorder (MDD) is often marked by impaired motivation and reward processing, known as anhedonia. Many patients do not respond to first-line treatments, and improvements in motivation can be slow, creating an urgent need for rapid interventions. Recently, we demonstrated that transcutaneous auricular vagus nerve stimulation (taVNS) acutely boosts effort invigoration in healthy participants, but its effects on depression remain unclear.ObjectiveTo assess the impact of taVNS on effort invigoration and maintenance in a sample that includes patients with MDD, evaluating the generalizability of our findings.MethodsWe used a single-blind, randomized crossover design in 30 patients with MDD and 29 matched (age, sex, and BMI) healthy control participants (HCP).ResultsConsistent with prior findings, taVNS increased effort invigoration for rewards in both groups during Session 1 (p=.040), particularly for less wanted rewards in HCP (pboot<.001). However, invigoration remained elevated in all participants, and no acute changes were observed in Session 2 (Δinvigoration=3.52,p=.093). Crucially, throughout Session 1, we found taVNS-induced increases in effort invigoration (pboot=.008) and wanting (pboot=.010) in patients with MDD, with gains in wanting maintained across sessions (Δwanting=0.06,p=.97).ConclusionsOur study replicates the invigorating effects of taVNS in Session 1 and reveals its generalizability to depression. Furthermore, we expand upon previous research by showing taVNS-induced conditioning effects on invigoration and wanting within Session 1 in patients that were largely sustained. While enduring motivational improvements present challenges for crossover designs, they are highly desirable in interventions and warrant further follow-up research.Graphical abstract

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“…Likewise, taVNS may enhance sensitivity to interoceptive signals 12,17 contributing to effortful behavior and the subjective evaluation of costs and benefits of action 16,81,82 .…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression

Ferstl,

Kühnel,

Klaus

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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Non-invasive stimulation of vagal afferents reduces gastric frequency

Abstract: taVNS reduces gastric frequency Teckentrup et al. 2

Cited by 1 publication

References 26 publications

Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression

Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression

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