Non-invasive skin measurement methods and diagnostics for vitiligo: a systematic review

Abdi, Parsa; Anthony, Michelle; Farkouh, Christopher; Chan, Airiss R.; Kooner, Amritpal; Qureshi, Saeed A.; Maibach, Howard I.

doi:10.3389/fmed.2023.1200963

Cited by 5 publications

(5 citation statements)

References 84 publications

(53 reference statements)

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“…Histopathology is the gold standard procedure for diagnosing vitiligo, but since it is invasive, it is not often accepted by patients. 14 Therefore, dermoscopy is emerging as a unique diagnostic method for vitiligo that eliminates the necessity for a skin sample. Based on the finding it can be concluded that dermatoscopy is an excellent method for diagnosing vitiligo and assessing disease activity.…”

Section: Discussionmentioning

confidence: 99%

Dermatoscope as a tool to determine the stability of vitiligo

Sindhuri,

Karim,

Patel

et al. 2024

IJCED

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Vitiligo is characterised by depigmentation of the skin that occurs without any prior inflammation. In vitiligo, dermatoscopy acts as an auxiliary technique for confirming the diagnosis and also assists in the assessment of disease activity. Present study was done to characterise the deratmoscopic characteristics of vitiligo and to assess the diagnostic utility of dermatoscopy in vitiligo patients. It was cross-sectional observational study conducted over a period of eighteen months from July 2021 to December 2022 in Department of Dermatology, Venereology and Leprosy of tertiary care teaching hospital in Mumbai, India. 50 adults of either sex or age more than 18 years of age attending dermatology outpatient department with a clinical diagnosis of vitiligo constituted the study population. Based on dermatoscopy, 36% of the lesions were unstable and rest 64% were stable. Perilesional and perifollicular hyperpigmentation was significantly associated with stability, while trichome border, satellite lesions and microkoebner phenomenon were found to be significantly associated with unstability of vitiligo. Dermatoscopy is an excellent method for diagnosing vitiligo and assessing disease activity. Since the stability of vitiligo necessitates surgical intervention, dermatoscopic examination may be of great assistance in determining disease activity.

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Section: Discussionmentioning

confidence: 99%

Dermatoscope as a tool to determine the stability of vitiligo

Sindhuri,

Karim,

Patel

et al. 2024

IJCED

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“… 8-10 , 12 , 13 , 15 , 21 Although designed for objective measurements, instrumental tools are subject to operator-dependent data acquisition and interpretation, introducing subjectivity that, along with regular calibration needs, can lead to considerable intraobserver and interobserver variabilities. 22-25 Moreover, these techniques tend to focus on specific skin characteristics, such as hydration or elasticity, rather than providing an all-encompassing assessment of skin quality. Existing validated clinical scales are designed to isolate individual skin factors or specifically measure the degree of skin aging.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Composite Skin Quality Scale

Gold,

Lorenc,

Bass

et al. 2024

Aesthetic Surgery Journal Open Forum

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Background The increasing demand for skin quality interventions in aesthetic medicine underscores the necessity for objective, evidence-based assessment tools that may be used to evaluate novel interventions or devices. Objectives To develop and validate a 5-point photo-numeric rating scale for assessing overall skin quality, including radiance, color evenness, and smoothness. Methods The IBSA (Institut Biochimique SA) Composite Skin Quality Scale was developed and underwent live validation with 88 real-world patients, chosen to encompass a broad spectrum of skin qualities and Fitzpatrick skin types. Scale validation was performed by board-certified plastic surgeons and dermatologists over 2 rounds, 2 weeks apart. Reliability was assessed via intrarater and interrater agreements, utilizing weighted kappa statistics and intraclass correlation coefficient (ICC). The scale's ability to discern a clinically relevant 1-grade difference was evaluated with 72 photo pairs. Results Combined intrarater reliability results showed weighted kappa values of 0.812 (right side) and 0.815 (left side), and an ICC of 0.903 for both sides, indicating almost perfect agreement. Interrater reliability ranged from substantial to almost perfect, with kappa coefficients between 0.654 and 0.853, and ICCs from 0.657 to 0.855 across all rater pairs in both rounds. The ability to detect a clinically relevant 1-point difference using the scale was established. Conclusions Integrating various key aspects of skin quality, the IBSA Composite Skin Quality Scale is a clinically relevant and highly reliable tool, suitable for skin assessment in clinical studies of new aesthetic technologies and products.

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“…(4) To this day, the diagnosis of vitiligo continues to rely mainly on clinical presentation. (5) Current therapies to treat vitiligo include topical anti-inflammatory treatments, phototherapy, but also oral steroids, conventional immunosuppressants/immunomodulators, new targeted treatments such as Janus Kinase (JAK) inhibitors and surgical interventions. (6) However, these treatments are often only partially effective, cause adverse events and relapse of the disease can be seen after stopping treatment.…”

Section: Introductionmentioning

confidence: 99%

Proteomics data in vitiligo: a scoping review

Berrevoet,

Van Nieuwerburgh,

Deforce

et al. 2024

Preprint

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An unbiased screening of which proteins are deregulated in vitiligo using proteomics can offer an enormous value. It could not only reveal robust biomarkers for detecting disease activity but can also identify which patients are most likely to respond to treatments. We performed a scoping review searching for all articles using proteomics in vitiligo. Eight manuscripts could be identified. Unfortunately, very limited overlap was found in the differentially expressed proteins between studies (15 out of 272; 5,51%) with variable degrees of the type of proteins and a substantial variety in the prevalence of acute phase proteins (range: 6-65%). Proteomics research has therefore brought little corroborating evidence on which proteins are differentially regulated between vitiligo patients and healthy controls or between active and stable vitiligo patients. While a limited patient size is an obvious weakness for several studies, an incomplete description of patient characteristics is an unfortunate and avoidable shortcoming. Additionally, the variations in the used methodology and analyses may further contribute to the overall observed variability. Nonetheless, more recent studies investigating the response to treatment seem to be more robust, as more differentially expressed proteins that have previously been confirmed to be involved in vitiligo were found. The further inclusion of proteomics analyses in clinical trials is recommended to increase insights into the pathogenic mechanisms in vitiligo and identify reliable biomarkers or promising drug targets. A harmonization in the study design, reporting and proteomics methodology could vastly improve the value of vitiligo proteomics research.

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Non-invasive skin measurement methods and diagnostics for vitiligo: a systematic review

Cited by 5 publications

References 84 publications

Dermatoscope as a tool to determine the stability of vitiligo

Dermatoscope as a tool to determine the stability of vitiligo

Development and Validation of a Composite Skin Quality Scale

Proteomics data in vitiligo: a scoping review

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