Non-invasive Skin Imaging in Cutaneous Lymphomas

Taleb, Eyal; Yélamos, Oriol; Ardigo, Marco; Christensen, Rachel E.; Geller, Shamir

doi:10.1007/s40257-023-00824-1

Cited by 4 publications

(6 citation statements)

References 56 publications

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“…In this case, dermoscopy showed known features of B‐cell lymphomas, 3 but was not conclusive in distinguishing HL from B‐cells lymphoma); on the contrary RCM showed characteristic features that made it possible to correlated with histological characteristics: the presence of large polynucleated cells with uneven boundaries can correlated with Reed‐Stemberg cells, round blood vessels (“buttonholes”), sclerosis and inflammatory cells with dilated vessels and dermal sclerosis.…”

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confidence: 65%

“… 2 Specific clinical aspect consist of papules, plaques, nodules or tumors, ulcerative lesions, and combinations of them, as well as erythroderma 1 ; non‐specific clinical aspect might show as pityriasis‐like, psoriatic, erythema nodosum, or eczematoid. 2 The cutaneous manifestations of B‐cell lymphomas have been described in the literature using dermoscopy and reflectance confocal microscopy (RCM) 3 , 4 : on dermoscopy out‐of‐focus short linear vessels on a salmon colored background are the known features of dermoscopic criteria; on RCM focal parakeratosis, inflammatory cells, dermal sclerosis and dilated vessels represents the RCM criteria of B‐cells lymphomas. 3 However, the dermoscopic and RCM features of HL have not been yet shown.…”

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confidence: 99%

“…cutaneous manifestations of B-cell lymphomas have been described in the literature using dermoscopy and reflectance confocal microscopy (RCM) 3,4 : on dermoscopy out-of-focus short linear vessels on a salmon colored background are the known features of dermoscopic criteria; on RCM focal parakeratosis, inflammatory cells, dermal sclerosis and dilated vessels represents the RCM criteria of B-cells lymphomas. 3 However, the dermoscopic and RCM features of HL have not been yet shown. Here we present a case of HL with cutaneous involvement in an 81year-old woman, characterized by a single nodule, that enabled us to identify a systemic condition.…”

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confidence: 99%

“…Compared to HL, where Reed-Sternberg cells are often large, polynucleated, and easily identifiable, non-Hodgkin's lymphoma tumor cells exhibit greater morphological heterogeneity. 3 Furthermore, RCM can assist physicians in distinguishing HL from other nodules, such as melanoma, Merkel cell carcinoma, or basal cell carcinoma. 5 Further studies are nevertheless needed to investigate whether HL diagnosis may be improved by dermoscopy and RCM.…”

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confidence: 99%

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A case of Hodgkin lymphoma with cutaneous involvement assessed with dermoscopy and reflectance confocal microscopy

Alma,

Fiorito,

Casari

et al. 2024

Skin Research and Technology

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Dear editor, Hodgkin lymphoma (HL) is a haematological disorder of the lymphatic system. 1 Cutaneous involvement is uncommon in HL (<1%) and has been observed in both specific and non-specific manifestations. 2 Specific clinical aspect consist of papules, plaques, nodules or tumors, ulcerative lesions, and combinations of them, as well as erythroderma 1 ; non-specific clinical aspect might show as pityriasis-like, psoriatic, erythema nodosum, or eczematoid. 2 The F I G U R E 1 Hodgkin Lymphoma with cutaneous involvement. Clinical image (A): Ulcerated nodule on the left thigh; Dermoscopic image (B): structureless milky-red areas and serpentine and glomerular vessels. RCM image (500 µm x 500 µm) (C): large polynucleated cell with uneven boundaries "Reed-Stemberg cell" (yellow circle), dilated round blood vessels "buttonholes like" (white squares), sclerosis (blue star). Histopathological image (D): Hodgkin cell (blue arrow), Reed-Stemberg cell (yellow circle), vessels (white squares) and multiple inflammatory cells (magnification 40×).

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confidence: 65%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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A case of Hodgkin lymphoma with cutaneous involvement assessed with dermoscopy and reflectance confocal microscopy

Alma,

Fiorito,

Casari

et al. 2024

Skin Research and Technology

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“…The use of high-frequency intraoral ultrasonographic examination of the oral mucosa remains relatively uncommon in many healthcare centers. However, both our study and the existing literature have demonstrated its promising potential [44][45][46][47]. Our research aimed to evaluate the diagnostic accuracy of high-frequency ultrasound (HFUS) in assessing TT and DOI in oral cavity lesions.…”

Section: Discussionmentioning

confidence: 92%

Reliability of Ultrasonographic Assessment of Depth of Invasion and Tumor Thickness in Intraoral Mucosa Lesions: A Preliminary Experience

Russo,

Patanè,

Fusco

et al. 2024

JCM

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Introduction: Despite the progress made in multidisciplinary care, there has been little improvement in the oncologic outcomes of oral cavity squamous cell carcinomas (OSCCs). In the latest edition of the TNM staging, “depth of invasion” (DOI) has recently been introduced as one of the criteria for determining the T stage, alongside other factors. DOI is widely recognized as an independent risk factor for nodal metastases and is a crucial consideration in the preoperative staging of OSCCs, along with measurements of tumor thickness (TT). While various diagnostic methods exist for assessing DOI, intraoral ultrasonography (IOUS) has gained popularity for its efficacy in evaluating OSCCs. Methods: This study sought to evaluate the diagnostic accuracy and reliability of ultrahigh-frequency ultrasound (UHFUS) in assessing oral cavity lesions compared to histopathological analysis. Results: The results revealed strong reliability in ultrasonographic measurements (ICC TT: 0.94; ICC DOI: 0.97) and distinct ultrasonographic features specific to different oral pathologies. This highlights the potential of UHFUS as a non-invasive imaging tool for precise diagnostic evaluations. Conclusions: Despite limitations such as a small sample size and focus on specific lesions, these promising results suggest that UHFUS could significantly enhance oral lesion diagnostics. Further research involving larger cohorts is necessary to validate and build upon these initial findings.

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Preliminary Experience in Ultra-High Frequency Ultrasound Assessment of Cutaneous Primary Lymphomas: An Innovative Classification

Russo,

Patanè,

Gagliardi

et al. 2024

Cancers

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Background: Primary cutaneous lymphoma (PCL) is a rare form of extranodal non-Hodgkin’s lymphoma characterized by malignant lymphocytes confined to the skin. Accurate diagnosis and staging are crucial for optimal management, yet radiological literature on imaging PCL remains limited. This study aims to delineate the imaging characteristics of PCLs using high and ultra-high frequency ultrasound (UHFUS) and proposes a classification system based on ultrasound findings. Methods: A cohort of 88 individuals with suspected PCL underwent high-resolution ultrasound (HRUS) and color Doppler examination of lesions. Lesions were categorized based on sonographic appearance, and subsequent histopathological assessment confirmed the diagnosis. Results: Ultrasound imaging revealed distinct patterns for primary cutaneous T-cell lymphomas (PCTCL) and primary cutaneous B-cell lymphomas (PCBCL), with characteristic features such as hypoechoic nodules, pseudonodular lesions, and dermal infiltration. Histopathological analysis confirmed the ultrasound findings, supporting the proposed classification system. Conclusions: Ultrasonography, particularly UHFUS, offers valuable insights into the imaging characteristics of primary cutaneous lymphomas, aiding the accurate diagnosis and assessment of treatment response. The proposed classification system based on ultrasound findings enhances the diagnostic approach to PCLs, and paves the way for improved patient care and management strategies.

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Non-invasive Skin Imaging in Cutaneous Lymphomas

Cited by 4 publications

References 56 publications

A case of Hodgkin lymphoma with cutaneous involvement assessed with dermoscopy and reflectance confocal microscopy

A case of Hodgkin lymphoma with cutaneous involvement assessed with dermoscopy and reflectance confocal microscopy

Reliability of Ultrasonographic Assessment of Depth of Invasion and Tumor Thickness in Intraoral Mucosa Lesions: A Preliminary Experience

Preliminary Experience in Ultra-High Frequency Ultrasound Assessment of Cutaneous Primary Lymphomas: An Innovative Classification

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