Non‐invasive quantitation of liver iron‐overload by magnetic resonance imaging

Kaltwasser, J. P.; Gottschalk, René; Schalk, K. P.; Hartl, W

doi:10.1111/j.1365-2141.1990.tb02596.x

Cited by 139 publications

(103 citation statements)

References 9 publications

(7 reference statements)

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“…Localized regions of increased magnetic susceptibility selectively shorten T2 relaxation time by creating regions of magnetic field nonuniformity [9]. Recently, KALTWASSER et al [10] reported a strong correlation between T2 relaxation time and hepatic iron concentration measured in biopsy specimens and a moderate correlation with serum ferritin. Likewise, GOMORI et al [11] found a significant correlation between hepatic T2 relaxation time and iron concentration measured in surgical wedge samples from the liver.…”

Section: Discussionmentioning

confidence: 99%

Respiratory function in patients with thalassaemia and iron overload

Dimopoulou¹,

Kremastinos²,

Maris³

et al. 1999

Eur Respir J

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Iron deposition in the respiratory system has been proposed as a potential cause of the ventilatory restrictive impairment seen in patients with thalassaemia major (TM) and iron overload. In this study, magnetic resonance imaging (MRI) measurements of the liver (T2 relaxation time) were used as a surrogate index of total body iron burden and the extent to which these measurements correlated with total lung capacity (TLC) in patients with TM was examined.Twenty-one patients (aged 255 yrs) with TM participated in the study. Standard pulmonary function tests were undertaken and the T2 relaxation time of the liver was measured in all patients.Ventilatory restrictive impairment (mean TLC 7411 (SD)% predicted) was the most common abnormality found in 71% of TM patients. There was no correlation between TLC (% pred) and T2 relaxation time (r=0.06, p=0.78). T2 relaxation time correlated weakly with average serum ferritin levels (r=-0.56, p=0.008).In conclusion, the data do not support the notion that the restrictive impairment in patients with thalassaemia major and iron overload is related to iron deposition in the respiratory system. Eur Respir J 1999; 13: 602±605.

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Section: Discussionmentioning

confidence: 99%

Respiratory function in patients with thalassaemia and iron overload

Dimopoulou¹,

Kremastinos²,

Maris³

et al. 1999

Eur Respir J

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“…[24][25][26] Localized MR spectroscopy measurements in the vicinity of the biopsy site have shown good correlation (r ϭ 0.95) with LIC up to 37.2 mg Fe/g dry tissue. 32 However, a limitation of localized spectroscopy measurements is the inability to measure or image the spatial variation in LIC.…”

Section: Liver Iron Heterogeneity and Rmentioning

confidence: 94%

Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

Pierre

Clark

Chua‐anusorn

et al. 2005

Blood

807

810

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“…Clinically useful estimates of the hepatic iron content have been obtained by a superconducting quantum interference device (SQUID) 5,6 and by magnetic resonance imaging (MRI). [7][8][9][10][11][12][13] Estimation of myocardial iron by the SQUID has so far not been reported, but a few studies have explored the use of MRI for this purpose. [14][15][16][17][18] Except for 2 studies, 14,18 all studies demonstrated a significant correlation between the applied myocardial MRI index and the serum ferritin concentration by heart-to-muscle signal intensity ratio (SIR) measurements obtained from spin-echo images, 15,17 by T2 relaxometry, 15,16 or by magnetization transfer ratio measurements.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool

Jensen

Christensen

et al. 2003

Blood

159

129

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Evaluation of myocardial iron during iron chelation therapy is not feasible by repeated endomyocardial biopsies owing to the heterogeneity of iron distribution and the risk of complications. Recently, we described a noninvasive method based on magnetic resonance imaging. Here, the method was used for repeated estimation of the myocardial iron content during iron chelation with deferrioxamine in 14 adult nonthalassemic patients with transfusional iron overload. We investigated the repeatability of the method and the relationship between the myocardial iron estimates and iron status. The repeatability coefficient (2s D ) was 2.8 mol/g in the controls (day-to-day) and 4.0 mol/g in the patients (within-day). Myocardial iron estimates were elevated in 10 of all 14 patients at first examination, but normalized in 6 patients after 6 to 18 months of treatment. If liver iron declined below 350 mol/g all but one of the myocardial iron estimates were normal or nearly normal. At start (R 2 ‫؍‬ 0.69, P ‫؍‬ .0014) and still after 6 months of iron chelation (R 2 ‫؍‬ 0.76, P ‫؍‬ .001), the estimates were significantly and more closely related to the urinary iron excretion than to liver iron or serum ferritin levels. In conclusion, our preliminary data, which may only pertain to patients with acquired anemias, suggest the existence of a critical liver iron concentration, above which elevated myocardial iron is present, but its extent seems related to the size of the chelatable iron pool, as reflected by the urinary iron excretion. This further supports the concept of the labile iron pool as the compartment directly involved in transfusional iron toxicity. (Blood. 2003;101:4632-4639)

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Non‐invasive quantitation of liver iron‐overload by magnetic resonance imaging

Cited by 139 publications

References 9 publications

Respiratory function in patients with thalassaemia and iron overload

Respiratory function in patients with thalassaemia and iron overload

Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool

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