Non‐invasive pulsatile arterial pressure and stroke volume changes from the human finger

Bogert, Lysander W. J.; Lieshout, Johannes J. van

doi:10.1113/expphysiol.2005.030262

Cited by 348 publications

(285 citation statements)

References 104 publications

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“…Rather than absolute values, in particular, relative changes in BP and stroke volume levels within an individual over time are most reliably measured by the Finometer device. 26,27 Throughout the experiment, we controlled for that the hand position was stable. After the baseline recording, the subjects were exposed to a standardized experimental stress protocol known as Trier Social Stress Test (TSST).…”

Section: Experimental Stress Protocolmentioning

confidence: 99%

Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth

Feldt

Räikkönen

Eriksson³

et al. 2007

J Hum Hypertens

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The relationships of body size and gestational age at birth with adult blood pressure (BP) are relatively modest compared to their stronger associations with cardiovascular disease. BP reactivity is a strong predictor of cardiovascular morbidity, and it is possible that reactivity, rather than resting level, is determined in utero. We investigated whether body size and gestational age at birth predict BP reactivity during experimentally induced psychosocial stress in late adulthood. A total of 73 men and 80 women born after 36 weeks' gestation in Helsinki, Finland, during 1934-1944 underwent the Trier Social Stress Test (TSST); a standardized psychosocial stress test consisting of a public speech and an arithmetic task. Changes in BP were monitored continuously by a non-invasive finger photoplethysmography (Finometer, FMS, Amsterdam, The Netherlands). The results showed that the most robust early determinant of BP reactivity was gestational age; however, with opposite relationships between the sexes (P for interaction o0.001). A 1-week increase in gestational age was associated with a 3.1 mm Hg (95% confidence interval (CI), 0.2 to 6.0) and 1.2 mm Hg (95% CI, À0.1 to 2.6) decreases in systolic and diastolic BP reactivity in women, but with 5.2 mm Hg (95% CI, 1.9 to 8.4) and 2.3 mm Hg (95% CI, 0.9 to 3.8) increases in men. In conclusion, normal variation in gestational age at birth predicts cardiovascular stress reactivity in later adulthood. Given that hypothalamic-pituitary-adrenal axis contributes to the regulation of autonomic nervous system function and the timing of parturition, and shows well-established sex differences, we speculate a role for early programming of this axis in explaining the findings.

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Section: Experimental Stress Protocolmentioning

confidence: 99%

Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth

Feldt

Räikkönen

Eriksson³

et al. 2007

J Hum Hypertens

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“…Noninvasive arterial BP waveform was recorded continuously using volume‐clamp photoplethysmography through a finger cuff, which is part of the Finapres™ system (Finapres Medical Systems, Amsterdam, The Netherlands) 18. All raw data including BP waveforms were used to derive real‐time autonomic indices by a NeuroScope using the VaguSoft™ software (Medifit Instruments Ltd, London, UK).…”

Section: Methodsmentioning

confidence: 99%

Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success

Saxena

Shour

Shah

et al. 2018

JAHA

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BackgroundRenal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α‐1‐adrenoceptor‐mediated autotransfusion during the Valsalva maneuver.Methods and ResultsIn this substudy of the Wave IV Study: Phase II Randomized Sham Controlled Study of Renal Denervation for Subjects With Uncontrolled Hypertension, we enrolled 23 subjects with resistant hypertension. They were randomized either to bilateral renal denervation using therapeutic levels of ultrasound energy (n=12) or sham application of diagnostic ultrasound (n=11). Within‐group changes in autonomic parameters, office and ambulatory blood pressure were compared between baseline and 6 months in a double‐blind manner. There was significant office blood pressure reduction in both treatment (16.1±27.3 mm Hg, P<0.05) and sham groups (27.9±15.0 mm Hg, P<0.01) because of which the study was discontinued prematurely. However, during the late phase II (Iii) of Valsalva maneuver, renal denervation resulted in substantial and significant reduction in mean arterial pressure (21.8±25.2 mm Hg, P<0.05) with no significant changes in the sham group. Moreover, there were significant reductions in heart rate in the actively treated group at rest (6.0±11.5 beats per minute, P<0.05) and during postural changes (supine 7.2±8.4 beats per minute, P<0.05, sit up 12.7±16.7 beats per minute, P<0.05), which were not observed in the sham group.ConclusionsBlood pressure reduction per se is not necessarily a marker of successful renal nerve ablation. Reduction in splanchnic autotransfusion following renal denervation has not been previously demonstrated and denotes attenuation of (renal) sympathetic efferent activity and could serve as a marker of procedural success.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT02029885.

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“…40 The Modelflow method assumes a population average of aortic area depending on gender, age, height and weight. Several studies have validated the Modelflow method compared with standard invasive techniques and indicate that this method provides a reliable estimate of changes in cardiac output in a variety of physiological 41 and pathological 42,43 conditions.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Identical pattern of cerebral hypoperfusion during different types of syncope

et al. 2009

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Syncope is caused by insufficient oxygen supply to the brain. There have been attempts to classify syncope on the basis of defects in the venous system, arterial system (that is impaired systemic vascular resistance) or a combination of the two (that is mixed). We examined the hypothesis that a comparable decrease in cerebral perfusion would be evident at pre-syncope irrespective of the category of dysfunction. Young healthy volunteers (N ¼ 37) participated. The protocol consisted of 15 min supine rest, followed by 601 head-up tilt and lower body suction in increments of À10 mm Hg for 5 min each until pre-syncope. Beat-to-beat blood pressure (BP) (Finometer or intra-arterial), cardiac output (Finometer), middle cerebral artery blood velocity (MCAv), end-tidal CO 2 and cerebral oxygenation were monitored continuously. At pre-syncope, mixed dysfunction was common (21 out of 37 participants), followed by venular dysfunction (15 out of 37 participants). In the venular and mixed groups, comparable orthostatic tolerance and declines in BP (À37 vs À43% from baseline, respectively), end-tidal PCO 2 , MCAv (À35 vs À38%) and cerebral oxygenation (À5 vs À7%) were evident despite distinct mechanisms purportedly being responsible for the hypotension. Although different determinants of hypotension do exist, cerebral hypoperfusion occurs to a similar extent.

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Non‐invasive pulsatile arterial pressure and stroke volume changes from the human finger

Cited by 348 publications

References 104 publications

Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth

Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth

Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success

Identical pattern of cerebral hypoperfusion during different types of syncope

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