Non-invasive perinatal necropsy by magnetic resonance imaging

Brookes, Jocelyn; Hall-Craggs, M. A.; Sams, V. R.; Lees, W. R.

doi:10.1016/s0140-6736(96)02287-8

Cited by 169 publications

(124 citation statements)

References 10 publications

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“…Although an autopsy is optimal, earlier studies have acknowledged the value of MRI as an alternative, 21 particularly for cerebral pathology. 22 Our low performance rate of MRI (6.0%) is probably due to our high autopsy rate, clinicians not being familiar with fetal MRI and unavailability of MRI services.…”

Section: -20mentioning

confidence: 99%

Evaluation of 1025 fetal deaths: proposed diagnostic workup

Korteweg

Erwich

Timmer

et al. 2012

American Journal of Obstetrics and Gynecology

102

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Section: -20mentioning

confidence: 99%

Evaluation of 1025 fetal deaths: proposed diagnostic workup

Korteweg

Erwich

Timmer

et al. 2012

American Journal of Obstetrics and Gynecology

102

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“…This study found that, in 60% of cases, MRI had equivalent or better diagnostic sensitivity than conventional autopsy, but included only 20 patients. Since then, many other similar small-scale studies [16][17][18][19][20][21] have shown the potential of PMMR, particularly for the central nervous system (CNS) ( Table 1). Brain and spinal cord anomalies account for 20% of fatal congenital abnormalities in foetuses, and PMMR has a high sensitivity and specificity for detecting these abnormalities in foetuses.…”

mentioning

confidence: 99%

Post-mortem MRI as an alternative to non-forensic autopsy in foetuses and children: from research into clinical practice

Addison¹,

Arthurs²,

Thayyil³

2014

BJR

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Although post-mortem MRI (PMMR) was proposed as an alternative to conventional autopsy more than a decade ago, the lack of systematic validation has limited its clinical uptake. Minimally invasive autopsy (MIA) using PMMR together with ancillary investigations has now been shown to be as accurate as conventional autopsy in foetuses, newborns and infants and is particularly useful for cerebral, cardiac and genitourinary imaging. Unlike conventional autopsy, PMMR provides a permanent three-dimensional auditable record, with accurate estimation of internal organ volumes. MIA is becoming highly acceptable to parents and professionals, and there is widespread political support and public interest in its clinical implementation in the UK. In the short to medium term, it is desirable that a supraregional network of specialist centres should be established to provide this service within the current National Health Service framework.

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“…15 MRI was found to be less useful in cardiovascular anomalies but good at demonstrating CNS anomalies, though it failed to provide the microscopic detail possible with histological examination. 15 Another landmark scheme in the UK started in March 1997 when the Jewish community in Manchester funded three MRI facilities to take the work of six coroners. 16 The bodies examined were predominantly, though not entirely, Jewish.…”

Section: Uncertainties In Death Certificationmentioning

confidence: 97%