Non-invasive obstetric anal sphincter injury diagnostics using impedance spectroscopy

Borycka-Kiciak, Katarzyna; Młyńczak, Marcel; Kiciak, Adam; Pietrzak, Piotr; Dziki, Adam

doi:10.1038/s41598-019-43637-1

Cited by 6 publications

(9 citation statements)

References 37 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This exam represents a novel, non-invasive technique, and it appears to be safe and reproducible, with high sensitivity and specificity in detecting anal sphincter injuries, causing no additional discomfort when compared with physical rectal examination [ 58 , 59 ]. Furthermore, this method can be helpful in the assessment of sphincter impairment sustained by neurogenic damages.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives

Spinelli

Laurenti

Carrano

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

Perineal injury during childbirth is a common event with important morbidity associated in particular with third-and-fourth degree perineal tears (also referred to as obstetric anal sphincter injuries—OASIS). Early diagnosis of these damages is mandatory to define a prompt therapeutic strategy and thus avoid the development of late-onset consequences, such as faecal incontinence. For this purpose, various diagnostic exams can be performed after a thorough clinical examination. The management of OASIS includes several measures and should be individualized according to the timing and features of the clinical presentation.

show abstract

Section: Diagnosismentioning

confidence: 99%

Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives

Spinelli

Laurenti

Carrano

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results showed no significant difference between basal and reflex tear osmolarity. This result may indicate that the tear-collection techniques that we explained in detail above do not affect the sample content and results [ 90 ].…”

Section: Emerging Applications Of Tear-based Electrochemical Detectionmentioning

confidence: 99%

Emerging Applications of Electrochemical Impedance Spectroscopy in Tear Film Analysis

et al. 2022

View full text Add to dashboard Cite

Human tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, mRNA, enzymes and cytokines in the tear film, collected by noninvasive methods, can provide significant results for sustaining a predictive, preventive and personalized medicine regarding various diseases such as glaucoma, diabetic retinopathy, keratoconus, dry eye, cancer, Alzheimer’s disease, Parkinson’s disease and COVID-19. Electrochemical impedance spectroscopy (EIS) offers a powerful technique for analyzing these biomarkers. EIS detects electrical equivalent circuit parameters related to biorecognition of receptor–analyte interactions on the electrode surface. This method is advantageous as it performs a label-free detection and allows the detection of non-electroactive compounds that cannot be detected by direct electron transfer, such as hormones and some proteins. Here, we review the opportunities regarding the integration of EIS into tear fluid sampling approaches.

show abstract

“…Therefore, it has been used as a physical marker of tissue condition, changing along with parameters such as microscopic structure, hydration, electrolyte concentration, and others [41][42][43][44]. For these reasons, feasibility studies of impedance spectroscopy application for OASI diagnostics have been undertaken [45,46]. As a result, a system called ONIRY has been developed.…”

Section: Gradementioning

confidence: 99%

Obstetric Anal Sphincter Injury Detection Using Impedance Spectroscopy with the ONIRY Probe

et al. 2021

Self Cite

View full text Add to dashboard Cite

Anal sphincter injuries occurring during natural deliveries are often a reason for severe complications, including fecal incontinence. Currently, approximately 80% of these injuries remain unrecognized. Therefore, it is crucial to focus on finding a way to diagnose such injuries as early as possible to apply the tailored treatment. This study aimed to assess the accuracy of impedance spectroscopy in the diagnostics of obstetric anal sphincter injuries (OASIs) using a specially designed rectal probe called the ONIRY Probe. The protocol of the clinical trials is described at NCT03769792. Twenty women after natural delivery were enrolled in the study and divided into two groups referring to the stage of a perineal tear (Group A: 1- or 2-degrees, and Group B: 3- or 4-degrees of a perineal tear; without or with sphincter injury, respectively). The study design included three visits during which a number of diagnostic tests were performed, including impedance spectroscopy, and 3-dimensional endoanal ultrasound, anorectal manometry, and physical examination as a reference. Statistical analysis comprised raw data analysis, as well as post-processing with the Synthetic Minority Oversampling Technique (SMOTE) method, as the output reference grade was highly imbalanced. A variety of machine learning techniques were applied for the OASI classification (≤2 vs. >2), and Wexner scale (=0 vs. >0). The best efficacies were obtained using Random Forest and k-Nearest Neighbors methods. Best accuracies were 93.3% and 99.6%, for raw and re-analyzed data, respectively, for ultrasound assessed by the OASI classification; and 79.8% and 97.0%, respectively, for clinical evaluation using the Wexner scale. Impedance spectroscopy performed using the ONIRY Probe appears to be a promising diagnostic technique for anal sphincter injury detection but requires further investigation (the next phase of the pilot clinical trial is described at NCT04181840).

show abstract

Non-invasive obstetric anal sphincter injury diagnostics using impedance spectroscopy

Cited by 6 publications

References 37 publications

Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives

Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives

Emerging Applications of Electrochemical Impedance Spectroscopy in Tear Film Analysis

Obstetric Anal Sphincter Injury Detection Using Impedance Spectroscopy with the ONIRY Probe

Contact Info

Product

Resources

About