Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy

Zhang, Yanrong; Buckmaster, Paul S.; Qiu, L.; Wang, Jing; Keunen, Olivier; Ghobadi, Sara Natasha; Huang, Ai; Hou, Qingyi; Li, Ningrui; Narang, Shivek; Habte, Frezghi; Bertram, Edward H.; Lee, Kevin M.; Wintermark, Max

doi:10.1016/j.expneurol.2021.113761

Cited by 7 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A histological analysis was performed on the non-epileptic treated rats and confirmed that there was no tissue damage induced by the sonication, indicating that FUS could be safely delivered to the target region ( Min et al, 2011 ). The seizure-suppressive effect of LIFU was later confirmed in other rodent studies ( Hakimova et al, 2015 ; Chen et al, 2019 ; Li et al, 2019a ; Zhang et al, 2021a , b , c ).…”

Section: Low Intensity Focused Ultrasoundsupporting

confidence: 55%

“…The seizure frequency in these mice was reduced by 21.2% ( Zhang et al, 2020 ). Later, the effectiveness of this method to lower the seizure frequency was confirmed in a controlled trial using rat models ( Zhang et al, 2021b ). In addition to neurophysiological effects, it has been shown that LIFU also affected behavior in epileptic mice, as LIFU significantly improved sociability, reflected by an increase in the time spent with an unfamiliar mouse, and depressive behavior, measured by the forced swim task, compared to non-sonicated epileptic animals ( Hakimova et al, 2015 ).…”

Section: Low Intensity Focused Ultrasoundmentioning

confidence: 94%

See 1 more Smart Citation

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

et al. 2022

View full text Add to dashboard Cite

Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates. Focused ultrasound, a novel non-invasive neurointerventional method is currently under investigation as a treatment alternative for DRE. By emitting one or more ultrasound waves, FUS can target structures in the brain at millimeter resolution. High intensity focused ultrasound (HIFU) leads to ablation of tissue and could therefore serve as a non-invasive alternative for resective surgery. It is currently under investigation in clinical trials following the approval of HIFU for essential tremor and Parkinson’s disease. Low intensity focused ultrasound (LIFU) can modulate neuronal activity and could be used to lower cortical neuronal hyper-excitability in epilepsy patients in a non-invasive manner. The seizure-suppressive effect of LIFU has been studied in several preclinical trials, showing promising results. Further investigations are required to demonstrate translation of preclinical results to human subjects.

show abstract

Section: Low Intensity Focused Ultrasoundsupporting

confidence: 55%

Section: Low Intensity Focused Ultrasoundmentioning

confidence: 94%

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The limitation of this study is that even with MR-guidance, there can be incomplete lesions. This same group repeated a similar experiment in the pilocarpine-induced rat model of epilepsy (49). The FUS parameters were similar, apart from using a 650 kHz frequency and a 90-s stimulation duration when targeting the hippocampus (49).…”

Section: Lifu Has Shown Promise For Seizure Modulation In Animal Studiesmentioning

confidence: 87%

Ultrasonic therapies for seizures and drug-resistant epilepsy

Cornelssen,

Finlinson,

Rolston

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

Ultrasonic therapy is an increasingly promising approach for the treatment of seizures and drug-resistant epilepsy (DRE). Therapeutic focused ultrasound (FUS) uses thermal or nonthermal energy to either ablate neural tissue or modulate neural activity through high- or low-intensity FUS (HIFU, LIFU), respectively. Both HIFU and LIFU approaches have been investigated for reducing seizure activity in DRE, and additional FUS applications include disrupting the blood–brain barrier in the presence of microbubbles for targeted-drug delivery to the seizure foci. Here, we review the preclinical and clinical studies that have used FUS to treat seizures. Additionally, we review effective FUS parameters and consider limitations and future directions of FUS with respect to the treatment of DRE. While detailed studies to optimize FUS applications are ongoing, FUS has established itself as a potential noninvasive alternative for the treatment of DRE and other neurological disorders.

show abstract

“…This is another adverse factor of QUIN as an endogenous neurotoxin. In non-invasive surgery, administering QUIN that is unable to break through the blood–brain barrier normally can be directed to the specific locations of the brain, reducing the frequency of seizures [ 117 ].…”

Section: Endogenous Neurotoxinsmentioning

confidence: 99%

Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins

Cao

Ismail

et al. 2021

IJMS

View full text Add to dashboard Cite

Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new research investigations on neurotoxins. An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation, and kynurenine pathway, can produce endogenous neurotoxins. Neurotoxins may damage the nervous system by inhibiting mitochondrial activity, increasing oxidative stress, increasing neuroinflammation, and up-regulating proteins related to cell death. This paper reviews the biological synthesis of various known endogenous neurotoxins and their toxic mechanisms.

show abstract

Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy

Cited by 7 publications

References 41 publications

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Ultrasonic therapies for seizures and drug-resistant epilepsy

Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins

Contact Info

Product

Resources

About