Non-invasive neuromodulation of dorsolateral prefrontal cortex to reduce craving in alcohol use disorder: A meta-analysis

Sorkhou, Maryam; Stogios, Nicolette; Sayrafizadeh, Negar; Hahn, Margaret; Agarwal, Sri Mahavir; George, Tony P.

doi:10.1016/j.dadr.2022.100076

Cited by 3 publications

(1 citation statement)

References 59 publications

(122 reference statements)

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“…In this study, we set out to investigate the early abstinence period in moderately to severely ill AUD inpatients, from a large-scale functional network perspective, with a focus on the DMN and FPN. A better understanding of the mechanisms underlying the early recovery from AUD may ultimately help to identify biomarkers that may serve as targets for personalized treatments in the future, with the FPN for example being an important target for non-invasive neurostimulation treatments, like repetitive transcranial magnetic stimulation (rTMS) (4,30,31). Our main aim was to investigate changes in the connectivity of our networks of interest in AUD patients during this early abstinence period.…”

Section: Introductionmentioning

confidence: 99%

Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study

et al. 2023

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The early abstinence period is a crucial phase in alcohol use disorder (AUD) in which patients have to find a new equilibrium and may start recovery, or conversely, relapse. However, the changes in brain functions during this key period are still largely unknown. We set out to study longitudinal changes in large-scale brain networks during the early abstinence period using resting-state scans. We scanned AUD patients twice in a well-controlled inpatient setting, with the first scan taking place shortly after admission and the second scan 4 weeks (±9 days) later near the end of the treatment period. We studied 37 AUD patients (22 males) and 27 healthy controls (16 males). We focused on three networks that are affected in AUD and underly core symptom dimensions in this disorder: the frontoparietal networks (left and right FPN) and default mode network (DMN). Both the whole brain and within network connectivity of these networks were studied using dual regression. Finally, we explored correlations between these brain networks and various neuropsychological and behavioral measures. In contrast to the controls (Z = −1.081, p = 0.280), the AUD patients showed a decrease in within left FPN connectivity (Z = −2.029, p = 0.042). However, these results did not survive a strict Bonferroni correction. The decrease in left FPN connectivity during the early abstinence period in AUD may reflect an initially upregulated FPN, which recovers to a lower resting-state connectivity level during subsequent weeks of abstinence. The AUD patients showed a trend for a positive association between the change in left FPN connectivity and trait anxiety (rs = 0.303, p = 0.068), and a trend for a negative association between the change in left FPN connectivity and delay discounting (rs = −0.283, p = 0.089) (uncorrected for multiple comparisons). This suggests that the FPN might be involved in top-down control of impulsivity and anxiety, which are important risk factors for relapse. Although there were no statistically significant results (after multiple comparison correction), our preliminary findings encourage further research into the dynamic neuroadaptations during the clinically crucial early abstinence period and could inform future study designs.

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Section: Introductionmentioning

confidence: 99%

Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study

et al. 2023

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No time to lose: the current state of research in rapid-acting psychotherapeutics

Gordon

Volkow

Koob

2023

Neuropsychopharmacol.

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GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

Dharavath,

Pina-Leblanc,

Tang

et al. 2023

Front. Neural Circuits

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Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.

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Non-invasive neuromodulation of dorsolateral prefrontal cortex to reduce craving in alcohol use disorder: A meta-analysis

Cited by 3 publications

References 59 publications

Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study

Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study

No time to lose: the current state of research in rapid-acting psychotherapeutics

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

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