Non-invasive monitoring of blood glucose using optical methods for skin spectroscopy—opportunities and recent advances

Delbeck, Sven; Vahlsing, Thorsten; Leonhardt, Steffen; Steiner, Gerald; Heise, H. M.

doi:10.1007/s00216-018-1395-x

Cited by 66 publications

(44 citation statements)

References 59 publications

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“…New optical wearables and RPM technologies have the potential to address many clinical scenarios related to the COVID-19 pandemic. Table 2 contains a brief summary of opportunities for remote and wearable optical technology development, both for COVID-19 and for the many Optical scattering FD-DOS, TD-DOS, SFDI, 40 OCT, 41 ESS Glucose Spectroscopy [42][43][44] Blood pressure PPG 45,46 Images of the eye, skin Ophthalmology, 47 OCT, 41 smartphone-based dermoscopy 48 Images of the cervix Colposcopy 49…”

Section: Areas Of Opportunity For the Biomedical Optics Community To mentioning

confidence: 99%

Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond

Roblyer

2020

J. Biomed. Opt.

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Significance: The COVID-19 pandemic is changing the landscape of healthcare delivery in many countries, with a new shift toward remote patient monitoring (RPM). Aim: The goal of this perspective is to highlight the existing and future role of wearable and RPM optical technologies in an increasingly at-home healthcare and research environment. Approach: First, the specific changes occurring during the COVID-19 pandemic in healthcare delivery, regulations, and technological innovations related to RPM technologies are reviewed. Then, a review of the current state and potential future impact of optical physiological monitoring in portable and wearable formats is outlined. Results: New efforts from academia, industry, and regulatory agencies are advancing and encouraging at-home, portable, and wearable physiological monitors as a growing part of healthcare delivery. It is hoped that these shifts will assist with disease diagnosis, treatment, management, recovery, and rehabilitation with minimal in-person contact. Some of these trends are likely to persist for years to come. Optical technologies already account for a large portion of RPM platforms, with a good potential for future growth. Conclusions: The biomedical optics community has a potentially large role to play in developing, testing, and commercializing new wearable and RPM technologies to meet the changing healthcare and research landscape in the COVID-19 era and beyond.

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Section: Areas Of Opportunity For the Biomedical Optics Community To mentioning

confidence: 99%

Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond

Roblyer

2020

J. Biomed. Opt.

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“…There are many publications with utilization of short-and long-wave NIR radiation, with even more sophisticated approaches by photoplethysmography for sensing the arterial vascular compartment for approaching the ultimate goal of noninvasive blood analysis by avoiding integral skin probing with different tissue compartments. However, we refer to our recent two reviews that summarized the state of the art, 2,3 as well as to another review by Yadav et al 4 Another vibrational spectroscopic approach, advantageously less affected by water interferences, is Raman spectroscopy, often complementary to IR spectroscopy. However, it is based on the interaction of visible and short-wave near IR laser radiation with high penetration depth into skin, revealing another chemical fingerprint of the target analyte.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Opportunities and Limitations of Mid-Infrared Skin Spectroscopy for Noninvasive Blood Glucose Monitoring

Delbeck

Heise

2020

J Diabetes Sci Technol

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Background: A wide range of optical techniques has recently been presented for the development of noninvasive methods for blood glucose sensing based on multivariate skin spectrum analysis, and most recent studies are reviewed in short by us. The vibrational spectral fingerprints of glucose, as especially found in the mid-infrared or Raman spectrum, have been suggested for achieving largest selectivity for the development of noninvasive blood glucose methods. Methods: Here, the different aspects on integral skin measurements are presented, which are much dependent on the absorption characteristics of water as the main skin constituent. In particular, different mid-infrared measurement techniques as realized recently are discussed. The limitations of the use of the attenuated total reflection technique in particular are elaborated, and confounding skin or saliva spectral features are illustrated and discussed in the light of recently published works, claiming that the attenuated total reflection technique can be utilized for noninvasive measurements. Results: It will be shown that the penetration depth of the infrared radiation with wavelengths around 10 µm is the essential parameter, which can be modulated by different measurement techniques as with photothermal or diffuse reflection. However, the law of physics is limiting the option of using the attenuated total reflection technique with waveguides from diamond or similar optical materials. Conclusions: There are confounding features from mucosa, stratum corneum, or saliva, which have been misinterpreted for glucose measurements. Results of an earlier study with multivariate evaluation based on glucose fingerprint features are again referred to as a negative experimental proof.

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“…3 In the past decades, minimally invasive and noninvasive glucose monitoring (NIGM) has gained considerable attention. 4 Continuous glucose monitoring (CGM) with indwelling sensors has focused on the interstitial compartment as an alternative for capillary testing. Despite the increasing number of CGM users, CGM is still quite invasive and not free of complications.…”

Section: Introductionmentioning

confidence: 99%

“…5 In contrast, noninvasive technologies, including electrical, thermal, acoustical, and optical methodologies, although desired for three decades, could not yet achieve a place in clinical routine. 4 Among the optical transdermal methods, Raman spectroscopy has gained considerable interest because of its glucose specificity. 6 Raman spectroscopy is based on the inelastic scattering of light that interacts with a molecule.…”

Section: Introductionmentioning

confidence: 99%

Proof of Concept for a New Raman-Based Prototype for Noninvasive Glucose Monitoring

Pleus

Schauer

Jendrike

et al. 2020

J Diabetes Sci Technol

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Background: Noninvasive glucose monitoring (NIGM) in diabetes is a long-sought-for technology. Among the many attempts Raman spectroscopy was considered as the most promising because of its glucose specificity. In this study, a recently developed prototype (GlucoBeam, RSP Systems A/S, Denmark) was tested in patients with type 1 diabetes to establish calibration models and to demonstrate proof of concept for this device in real use. Methods: The NIGM table-top prototype was used by 15 adult subjects with type 1 diabetes for up to 25 days at home and in an in-clinic setting. On each day, the subjects performed at least six measurement units throughout the day. Each measurement unit comprised two capillary blood glucose measurements, two scans with an intermittent scanning continuous glucose monitoring (CGM) system, and two NIGM measurements using the thenar of the subject’s right hand. Results: Calibration models were established using data from 19 to 24 days. The remaining 3-8 days were used for independent validation. The mean absolute relative difference of the NIGM prototype was 23.6% ± 13.1% for the outpatient days, 28.2% ± 9.9% for the in-clinic day, and 26.3% ± 10.8% for the complete study. Consensus error grid analysis of the NIGM prototype for the complete study showed 93.6% of values in clinically acceptable zones A and B. Conclusions: This proof of concept study demonstrated a practical realization of a Raman-based NIGM device, with performance on par with early-generation CGM systems. The findings will assist in further performance improvements of the device.

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Non-invasive monitoring of blood glucose using optical methods for skin spectroscopy—opportunities and recent advances

Cited by 66 publications

References 59 publications

Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond

Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond

Evaluation of Opportunities and Limitations of Mid-Infrared Skin Spectroscopy for Noninvasive Blood Glucose Monitoring

Proof of Concept for a New Raman-Based Prototype for Noninvasive Glucose Monitoring

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