Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography

Knickelbein, Jared E.; Tucker, William R; Kodati, Shilpa; Akanda, Marib; Sen, H. Nida

doi:10.1136/bjophthalmol-2016-309837

Cited by 20 publications

(23 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, although none of the OCTA data showed an association with peripheral capillary leakage on FA, there was a correlation between peripheral capillary leakage on FA and perivascular-peripapillary and macular thickening on en-face wide-field thickness maps. In keeping, a previous study on patients with Birdshot chorioretinopathy has shown that perivascular thickening on thickness maps corresponds to vasculitis and may be used to follow phlebitis and disease activity in patients with respective disease 17. Our findings broaden the spectrum of evaluable diseases, which makes en-face thickness maps a promising, additional tool to follow patients with uveitis.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

et al. 2018

View full text Add to dashboard Cite

PurposeTo evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA).MethodsThis is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort.Results164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more frequently observed in the choroidal OCTA slab (33.3% and 49.4%), choriocapillaris (CC; 31.4% and 48%) and deep capillary plexus (DCP; 9.6% and 34.6%) than in the superficial capillary plexus (SCP; 5% and 26.3%), respectively. Intermediate uveitis with vasculitis presented more frequently with non-perfusion and hypoperfusion in the DCP (p=0.003 and p=0.05, respectively) and SCP (p=0.007 and p=0.005, respectively) than intermediate uveitis without vasculitis. Peripheral capillary leakage on FA correlated with the presence of perivascular, macular and generalised thickening on en-face wide-field thickness maps (p=0.007). Ischaemia on FA was significantly associated with non-perfusion on wide-field OCTA in SCP and DCP (p=0.019 and p=0.027, respectively).ConclusionChanges in the choroid, CC and DCP are more frequently found than in the SCP on wide-field OCTA in intermediate uveitis. While wide-field OCTA is a reliable tool to detect capillary non-perfusion in intermediate uveitis, it was not helpful in determining disease activity.Trial registration numberNCT02811536.

show abstract

Section: Discussionsupporting

confidence: 78%

“…The degree of retinal thickness was graded according to the colour-coded thickness maps. Cool colours (green and blue) represent decreased thickness, while warm colours (yellow, orange and red) represent increased thickness 17. Qualitative analysis of capillary network abnormalities was then compared with FA.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Exudative vasculitis is usually evaluated by fundus fluorescein angiography (FFA) because it allows visualization of dye leakage through the impaired BRB . Additionally, independent groups have reported that a thickening of the perivascular structures can be visualized in exudative vasculitis and monitored with structural OCT scans in patients with birdshot chorioretinopathy . Further studies are needed to establish if these findings can be observed in other uveitic entities.…”

Section: Oct/octa Of the Retina In Uveitismentioning

confidence: 99%

Optical coherence tomography and optical coherence tomography angiography in uveitis: A review

Invernizzi

Cozzi

Staurenghi

2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Optical coherence tomography (OCT) has dramatically changed the understanding and management of uveitis and other ocular conditions. Currently, OCT angiography (OCTA) combines structural information with the visualization of blood flow within the imaged area. The aim of this review is to present the basic principles of OCT and OCTA interpretation and to investigate the role of these imaging techniques in the diagnosis and management of uveitis. Common complications of intraocular inflammation such as macular oedema and inflammatory choroidal neovascularization are often diagnosed and followed with OCT/OCTA scans. However, uveitis specialists can obtain much more information from tomographic scans. This review provides a comprehensive description of typical OCT/OCTA findings characterizing different ocular structures in uveitis, proceeding from the cornea to the choroid. A careful interpretation of OCT/OCTA images can help in the differential diagnosis, the prediction of clinical outcomes, and the follow‐up of patients with uveitis.

show abstract

“…Cool colours (green and blue) represent decreased thickness, while warm colours (yellow, orange and red) represent increased thickness. 17 Qualitative analysis of capillary network abnormalities was then compared with FA. Peripheral capillary leakage was compared with flow changes on the wide-field OCTA.…”

Section: Acquisition Of Octa Imagementioning

confidence: 99%

Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

et al. 2019

View full text Add to dashboard Cite

AimTo describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR).MethodsThis was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central macular thickness, were analysed. The eyes were classified into two groups depending on the presence or absence of CNV network on OCTA. BCVA, OCT parameters and CMD distribution were compared in the two groups at baseline using independent t-test.ResultA total of 13 (44.8 %) eyes had a CNV network, while only 9 out of the 13 eyes had pattern-I CNV. Among the eyes with CNV network (13 eyes), mean height of NSD was of 65.2±22.7 µ, whereas, among the eyes without CNV (16 eyes), it was 134.6±77.4 µ. The difference was statistically significant (p=0.013). There was no statistically significant difference between eye having a CNV and eyes without CNV in terms of other parameters.ConclusionA CNV network is seen in a large subset of patients with CMD in CSCR. A shallower subretinal fluid may point towards the presence of an underlying CNV network.

show abstract

Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography

Abstract: Evaluating large-vessel perivascular thickness on OCT scans may be a useful method for non-invasively monitoring posterior pole large-vessel retinal vasculitis.

Cited by 20 publications

References 16 publications

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

Optical coherence tomography and optical coherence tomography angiography in uveitis: A review

Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

Contact Info

Product

Resources

About