Non-invasive liver iron concentration measurement by MRI: Comparison of two validated protocols

Magnetic Resonance Imaging Quantification of Liver Iron

“…Also, body habitus may affect the homogeneity of the signal intensity across the image and complicate the analysis of signal intensity ratios. Finally, the technique requires several breathholds and total acquisition time including inter-breathhold intervals is about 10 minutes 65 .…”

Liver iron concentration quantification by MRI: are recommended protocols accurate enough for clinical practice?

“…This team has designed an MRI technique for any 0.5-, 1-, or 1.5-T MR system, and has developed a free-access, Internet-based calculation model [4]. This recommended protocol is now widely used in clinical practice, and many studies use the results obtained with it as the reference value for LIC [5][6][7][8]. It is considered reliable for LIC values under 350 μmol Fe/g; because of its simplicity and reproducibility, it is a useful option for standardising the quantification of LIC with MRI.…”

Quantitative Assessment of Intrahepatic Lipids Using Fat-Selective Imaging With Spectral-Spatial Excitation and In-/Opposed-Phase Gradient Echo Imaging Techniques Within a Study Population of Extremely Obese Patients

“…15,16 Signal decay between in-phase and opposed-phase images might not only be influenced by IHLs, but can also be significantly affected by increased intrahepatic deposition of body iron. 28,29 It has recently been shown that individual variations in the body iron load cause significant variations of the effective transverse relaxation time T2*. For this reason, a 2-dimensional multiecho gradient-echo breath-hold sequence was additionally performed in each subject for estimation of individual transverse relaxivity of the liver.…”