Non‐invasive liver fibrosis assessment correlates with collagen and elastic fiber quantity in patients with hepatitis C virus infection

Yasui, Yutaka; Abe, Tokiya; Kurosaki, Masayuki; Matsunaga, Kotaro; Higuchi, Masakazu; Tamaki, Nobuharu; Watakabe, Keiya; Okada, Mao; Wang, Wan; Shimizu, Takao; Takaura, Kenta; Masugi, Yohei; Nakanishi, Hiroyuki; Tsuchiya, Kaoru; Takahashi, Yuka; Itakura, Jun; Sakurai, Urara; Hashiguchi, Akinori; Sakamoto, Michiie; Izumi, Namiki

doi:10.1111/hepr.13286

Cited by 23 publications

(19 citation statements)

References 33 publications

(37 reference statements)

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“…Furthermore, because the invasiveness of liver biopsy precludes repeated examinations, longitudinal assessment of hepatic fibrosis and steatosis is difficult. Recently, there have been several reports showing the utility of MRE‐based and MRI‐based PDFF for diagnosing hepatic fibrosis and steatosis . Imajo et al .…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance elastography (MRE) is a magnetic resonance imaging (MRI)‐based method for quantitative imaging of tissue stiffness. MRE has been reported to be a useful method for diagnosing fibrosis in patients with chronic liver disease . In addition, proton density fat fraction (PDFF) measurement is an MRI‐based method for quantitative assessment of hepatic steatosis.…”

Section: Introductionmentioning

confidence: 99%

“…MRE has been reported to be a useful method for diagnosing fibrosis in patients with chronic liver disease. [17][18][19][20][21][22] In addition, proton density fat fraction (PDFF) measurement is an MRI-based method for quantitative assessment of hepatic steatosis. MRIdetermined PDFF is correlated with histologicallydetermined steatosis grade in patients with chronic liver disease.…”

Section: Introductionmentioning

confidence: 99%

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Liver stiffness does not affect ultrasound‐guided attenuation coefficient measurement in the evaluation of hepatic steatosis

Tada

Kumada

Toyoda

et al. 2019

Hepatology Research

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Aim Recently, a new method has been developed to diagnose hepatic steatosis with attenuation coefficients based on the ultrasound‐guided attenuation parameter (UGAP). We investigated whether fibrosis identified by hepatic stiffness measurements based on magnetic resonance elastography (MRE) affects attenuation coefficient measurement using UGAP for the evaluation of hepatic steatosis. Methods A total of 608 patients with chronic liver disease were analyzed. Correlations between magnetic resonance imaging‐determined proton density fat fraction (PDFF) or MRE value and attenuation coefficients were evaluated. In addition, the interaction between hepatic fibrosis and the attenuation coefficient was analyzed. Results The correlation coefficient (r) between PDFF values and attenuation coefficient values was 0.724, indicating a strong relationship. Conversely, the r between MRE values and attenuation coefficient values was −0.187, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on the attenuation coefficient based on UGAP, the P‐values for PDFF, MRE, and PDFF × MRE were < 0.001, 0.277, and 0.903, respectively. In patients with non‐alcoholic fatty liver disease (n = 169), the r between PDFF values and attenuation coefficient values was 0.695, indicating a moderate relationship. Conversely, the r between MRE values and attenuation coefficient values was −0.068, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on the attenuation coefficient based on UGAP, the P‐values for PDFF, MRE, and PDFF × MRE were <0.001, 0.948, and 0.706, respectively. Conclusion UGAP‐determined attenuation coefficient was weakly affected by liver stiffness, an indicator of hepatic fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liver stiffness does not affect ultrasound‐guided attenuation coefficient measurement in the evaluation of hepatic steatosis

Tada

Kumada

Toyoda

et al. 2019

Hepatology Research

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“…Several groups have reported the accuracy of magnetic resonance elastography and proton density fat fraction to be superior to TE in CLD. [39][40][41][42][43] Increasing availability of non-invasive diagnostic technology is beneficial for CLD patients.…”

Section: Discussionmentioning

confidence: 99%

Assessing the risk of hepatocellular carcinoma by combining liver stiffness and the controlled attenuation parameter

Izumi

Sho

Morikawa

et al. 2019

Hepatology Research

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Aim Ultrasound technology can now be used for liver stiffness measurement (LSM) and for evaluating the amount of hepatic fat quantitatively known as the controlled attenuation parameter (CAP). This study aimed to determine the applicable cut‐off values of LSM and the CAP for primary hepatocellular carcinoma (HCC), and to investigate their clinical usefulness for assessing HCC risk in patients with chronic liver disease. Methods A total of 1054 patients (88 with primary HCC and 966 without HCC) whose LSM and the CAP were measured by transient elastography with clinically evident hepatitis C virus (419 patients), hepatitis B virus (377 patients), and non‐alcoholic fatty liver disease (258 patients) were enrolled in this study. Subsequently, a total of 966 patients who did not have HCC initially were followed, and the usefulness of the cut‐off values of LSM and CAP for HCC development were evaluated. Results In hepatitis C virus patients, the incidence of HCC development was significantly higher among those with a combination of LSM ≥8.0 kPa and CAP ≤221 dB/m than among those with other values (log–rank test 0.0239, hazard ratio 2.66, 95%CI 1.07–6.47, P = 0.0362). In non‐alcoholic fatty liver disease patients, the incidence of HCC development was significantly higher among those with a combination of LSM ≥5.4 kPa and CAP ≤265 dB/m than among others (log–rank test 0.0040, hazard ratio 8.91, 95% CI 1.47–67.97, P = 0.0192). Conclusion In the hepatitis C virus and non‐alcoholic fatty liver disease groups, a combination of LSM and the CAP cut‐off values would be useful for screening to identify the high‐risk group for primary HCC development.

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“…The application of computer‐assisted quantitative analysis revealed that the pattern of liver fibrosis progression in NAFLD was different from that of chronic HCV infection: a striking difference was observed in fiber accumulation between Brunt's fibrosis stages F3 and F4 in NAFLD, in contrast to the somewhat linear association observed in chronic HCV infection . Moreover, the ranges of collagen and elastin levels in F4 stage NAFLD were larger than for stages F1–3 .…”

Section: Assessment Of Liver Fibrosismentioning

confidence: 95%

Precision pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision diagnosis of hepatocellular carcinoma

Ueno

Masugi

Yamazaki

et al. 2020

Pathology International

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Outcomes for patients with hepatocellular carcinoma (HCC) remain poor because the condition is often unresponsive to the available treatments. Consequently, the early and precise diagnosis of HCC is crucial to achieve improvements in prognosis. For patients with chronic liver disease, the assessment of liver fibrosis is also important to ascertain both the staging of fibrosis and the risk of HCC occurrence. Early HCC was first described in 1991 in Japan and was defined internationally in 2009. As the concept of early HCC spread, the multistage hepatocarcinogenesis process became accepted. Consequently, improvements in imaging technology made the early diagnosis of HCC possible. At present, the most appropriate therapeutic strategy for HCC is determined using an integrated staging system that assesses the tumor burden, the degree of liver dysfunction and the patient performance status; however, pathological and molecular features are not taken into account. The recent introduction of several new therapeutic agents will change the treatment strategy for HCC. Against this background, HCC subclassification based on tumor cellular and microenvironmental characteristics will become increasingly important. In this review, we give an overview of how pathological analysis contributes to understanding the development and progression of HCC and establishing a precision diagnosis of HCC.

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Non‐invasive liver fibrosis assessment correlates with collagen and elastic fiber quantity in patients with hepatitis C virus infection

Cited by 23 publications

References 33 publications

Liver stiffness does not affect ultrasound‐guided attenuation coefficient measurement in the evaluation of hepatic steatosis

Liver stiffness does not affect ultrasound‐guided attenuation coefficient measurement in the evaluation of hepatic steatosis

Assessing the risk of hepatocellular carcinoma by combining liver stiffness and the controlled attenuation parameter

Precision pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision diagnosis of hepatocellular carcinoma

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