Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI

Abstract

Quantitative 3D HR microMRI allowed for non-invasive longitudinal MT.ThC measurements in four different locations in both the normal and the operated rabbits. We concluded the MT.ThC measured in the minimum interbone distance area reflected the severity of the disease and was the most effective to measure the progression of the medial tibial cartilage destruction.

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

“…Macroscopically, the cartilage in ACLT knees seemed generally healthy at 3 weeks; however, by 9 weeks, fissures and full-depth erosions were evident. At 3 weeks, some irregularities in menisci were observed and, by 9 weeks, prominent lesions, more severe in the medial menisci, were present, consistent with previous findings (Boulocher et al , 2007; Chang et al , 1997). …”

Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring

“…Most of the in vivo animal models used for the investigation of osteoarthritis (OA) have undergone an intervention in the targeted joint [1,2,3,4]. Changes in the articular cartilage were documented after different periods following the operation as shown in literature after1-14 days [5], 2–6 weeks [6] and 6–52 weeks [7].…”

In vivo characterization of morphological properties and contact areas of the rat cartilage derived from high-resolution MRI

“…Rat models were selected due to their reasonable time life for observing the OA process from the beginning to the end [12]. High-resolution MRI technique was used due to its non-invasive characteristic [8] and especially its quality for analyzing small joint of animal models [13]. Manual segmentation was applied to separate cartilage tissue from its surrounding tissues.…”

“…Moreover, computational models derived from anatomical images and geometrical computing techniques showed their robustness in time consuming as well as in computing accuracy for morphological cartilage characterization [9][10]. Furthermore, high-field MRI specific sequences were recently used to improve the quality of the contrast between cartilages and surrounding tissues as well as the precision of the morphological assessment in human and animal cartilage models [11][12][13]. However, according to the best of our knowledge, there are few investigations using high-resolution MRI technique to monitor in vivo morphological properties and contact areas of the cartilage during OA process in clinical practice.…”

“…In vivo measurements have to be repeated many times to monitor the longitudinal evolution of the OA. Thus, animal models such as rat model or rabbit model could be used in research experimental set up for ethics reason [13]. For these reasons, the analysis and monitoring of OA are time-consuming tasks in clinical practice.…”