Non-invasive in vivo MRI detects long-term microstructural brain alterations related to learning and memory impairments in a model of inflammation-induced white matter injury

Pierre, Wyston C.; Zhang, Erjun; Londono, Irène; Leener, Benjamin De; Lesage, Frédéric; Lodygensky, Gregory A.

doi:10.1016/j.bbr.2022.113884

Cited by 4 publications

(1 citation statement)

References 161 publications

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“…It is conceivable that the abnormal brain development results in disordered emotional learning processes, which are exacerbated by environmental risk factors and persist into aduldhood. Initial studies in rodent models of prematurity have reported altered fear conditioning (Matsuda et al, 2021;Pierre et al, 2022;Xia et al, 2020). Furthemore, a reduced volume of the amygdala has been shown in very preterm-born infants, an important hub of the fear conditioning circuitry (Chau et al, 2019;Schmitz-Koep et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

Albayrak

Jablonski

Felderhoff‐Mueser

et al. 2023

Preprint

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Very preterm birth is associated with an increased risk for anxiety disorders. Abnormal brain development may result in disordered fear learning processes, which may be exacerbated by environmental risk factors and persist in adulthood. We tested the hypotheses that very preterm-born young adults displayed higher levels of fear conditioning, less differentiation between threat, CS+, and safety, CS-, signals and stronger resistance to extinction relative to term-born controls. A group of 37 very preterm-born young adults and 31 age- and sex-matched term-born controls performed a differential fear conditioning paradigm on two consecutive days. Acquisition and extinction training were performed on day 1. Recall and reinstatement were tested on day 2. Preterm-born participants showed significantly higher levels of anxiety in the Depression-Anxiety-Stress-Scale-21 questionnaire. The fear conditioning outcome measures, skin conductance response amplitudes and anxiety ratings, were overall higher in the preterm-born group compared to controls. Acquisition, extinction, recall and reinstatement of differential conditioned fear responses, CS+ > CS-, however, were not significantly different between the groups. There were no significant group by stimulus type interactions. The finding of preserved associative fear learning in very preterm-born young adults was unexpected and needs to be confirmed in future studies.

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Section: Introductionmentioning

confidence: 99%

Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

Albayrak

Jablonski

Felderhoff‐Mueser

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Image processing: an early detection tool for Alzheimer’s disease

Ballav,

Biswas,

Dey

et al. 2024

Smart Diagnostics for Neurodegenerative Disorders

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Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

Albayrak

Jablonski

Felderhoff‐Mueser

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Very preterm birth is associated with an increased risk for anxiety disorders. Abnormal brain development may result in disordered fear learning processes, which may be exacerbated by environmental risk factors and persist in adulthood. We tested the hypotheses that very preterm-born young adults displayed higher levels of fear conditioning, less differentiation between threat (CS+) and safety (CS−) signals, and stronger resistance to extinction relative to term-born controls. A group of 37 very preterm-born young adults and 31 age- and sex-matched term-born controls performed a differential fear conditioning paradigm on two consecutive days. Acquisition and extinction training were performed on day 1. Recall and reinstatement were tested on day 2. Preterm-born participants showed significantly higher levels of anxiety in the Depression-Anxiety-Stress-Scale-21 questionnaire. The fear conditioning outcome measures, skin conductance response amplitudes and anxiety ratings, were overall higher in the preterm-born group compared to controls. Awareness of CS-US contingencies was mildly reduced in preterms. Acquisition, extinction, recall and reinstatement of differential conditioned fear responses (CS+ > CS−), however, were not significantly different between the groups. There were no significant group by stimulus type interactions. The finding of largely preserved associative fear learning in very preterm-born young adults was unexpected and needs to be confirmed in future studies.

show abstract

Non-invasive in vivo MRI detects long-term microstructural brain alterations related to learning and memory impairments in a model of inflammation-induced white matter injury

Cited by 4 publications

References 161 publications

Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

Image processing: an early detection tool for Alzheimer’s disease

Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels

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