Non‐Invasive Imaging of the Tumor Microenvironment

Jordan, Bénédicte F.; Gallez, Bernard

doi:10.1002/9780470669891.ch11

Cited by 3 publications

(3 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methods to measure absolute pO 2 mostly encompass EPR oximetry and 19F relaxometry whereas indirect methods include blood oxygen level dependent (BOLD) MRI, Oxygen enhanced relaxation MRI, Oxygen enhanced longitudinal relaxation MRI, and positron emission tomography (PET) tracers retained in hypoxic regions. Of note, our group has also developed innovative methods to assess tumor oxygen consumption in vitro and in vivo , which have been reviewed elsewhere (Jordan and Gallez, 2011 ).…”

Section: Non-invasive Imaging Of Tumor Oxygenation and Perfusionmentioning

confidence: 99%

Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1

Jordan¹,

Sonveaux²

2012

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Radiotherapy and chemotherapy are widespread clinical modalities for cancer treatment. Among other biological influences, hypoxia is a main factor limiting the efficacy of radiotherapy, primarily because oxygen is involved in the stabilization of the DNA damage caused by ionizing radiations. Radiobiological hypoxia is found in regions of rodent and human tumors with a tissue oxygenation level below 10 mmHg at which tumor cells become increasingly resistant to radiation damage. Since hypoxic tumor cells remain clonogenic, their resistance to the treatment strongly influences the therapeutic outcome of radiotherapy. There is therefore an urgent need to identify adjuvant treatment modalities aimed to increase tumor pO2 at the time of radiotherapy. Since tumor hypoxia fundamentally results from an imbalance between oxygen delivery by poorly efficient blood vessels and oxygen consumption by tumor cells with high metabolic activities, two promising approaches are those targeting vascular reactivity and tumor cell respiration. This review summarizes the current knowledge about the development and use of tumor-selective vasodilators, inhibitors of tumor cell respiration, and drugs and treatments combining both activities in the context of tumor sensitization to X-ray radiotherapy. Tumor-selective vasodilation may also be used to improve the delivery of circulating anticancer agents to tumors. Imaging tumor perfusion and oxygenation is of importance not only for the development and validation of such combination treatments, but also to determine which patients could benefit from the therapy. Numerous techniques have been developed in the preclinical setting. Hence, this review also briefly describes both magnetic resonance and non-magnetic resonance in vivo methods and compares them in terms of sensitivity, quantitative or semi-quantitative properties, temporal, and spatial resolutions, as well as translational aspects.

show abstract

Section: Non-invasive Imaging Of Tumor Oxygenation and Perfusionmentioning

confidence: 99%

Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1

Jordan¹,

Sonveaux²

2012

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The high interstitial fluid pressure compared to that of normal cells is yet another key defining element of the tumour milieu. This is the result of the chaotic vasculature of solid tumours as previously described, due to high vessel permeability and cell density outside the vessels, low lymphatic drainage, and poor perfusion [ 23 ]. This causes problems for the administration of cancer therapeutics, which may not successfully be able to reach all tissues in sufficient quantities due to transcapillary transport [ 24 ].…”

Section: Tumour Microenvironmentmentioning

confidence: 99%

Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment

Umer

Good

Anné

et al. 2012

Journal of Toxicology

View full text Add to dashboard Cite

Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aimed at targeting these cells directly. Recent research has shifted towards understanding the tumour microenvironment and it's differences from that of healthy cells/tissues in the body and then to exploit these differences for treatmeat of the tumour. One such approach is utilizing anaerobic bacteria. Several strains of bacteria have been shown to selectively colonize in solid tumours, making them valuable tools for selective tumour targeting and destruction. Amongst them, the anaerobic Clostridium has shown great potential in penetration and colonization of the hypoxic and necrotic areas of the tumour microenvironment, causing significant oncolysis as well as enabling the delivery of therapeutics directly to the tumour in situ. Various strategies utilizing Clostridium are currently being investigated, and represent a novel area of emerging cancer therapy. This review provides an update review of tumour microenvironment as well as summary of the progresses and current status of Clostridial spore-based cancer therapies.

show abstract

“…Methods to measure absolute pO 2 mostly encompass EPR oximetry and 19 F relaxometry whereas indirect methods include Blood Oxygen LevelDependent (BOLD) MRI, Oxygen enhanced relaxation MRI, Oxygen enhanced longitudinal relaxation MRI and positron emission tomography (PET) tracers retained in hypoxic regions. Of note, our group has also developed innovative methods to assess tumor oxygen consumption in vitro and in vivo, which have been reviewed elsewhere (Jordan & Gallez, 2011).…”

Section: Tumor Oxygenation Measurementsmentioning

confidence: 99%