Non-invasive imaging of epileptic seizures<i>in vivo</i>using photoacoustic tomography

Zhang, Qizhi; Liu, Zhao; Carney, Paul R.; Yuan, Zhen; Chen, Huanxin; Roper, Steven N.; Jiang, Huabei

doi:10.1088/0031-9155/53/7/008

Cited by 73 publications

(69 citation statements)

References 20 publications

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“…If high frame rates are not required, it can also be inexpensively implemented as a laboratory system using a single mechanically scanned receiver and a stepper motordriven rotational stage. Although widely used, it is, in common with the spherical detection geometry, inevitably limited to applications such as small-animal [64][65][66][67][68][69][70][71][72][73] or breast [74,75] imaging. Figure 6 shows perhaps the simplest one-dimensional cylindrical scanner for two-dimensional cross-sectional imaging [64].…”

Section: Photoacoustic Tomography Imaging Systemsmentioning

confidence: 99%

Biomedical photoacoustic imaging

2011

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Photoacoustic (PA) imaging, also called optoacoustic imaging, is a new biomedical imaging modality based on the use of laser-generated ultrasound that has emerged over the last decade. It is a hybrid modality, combining the high-contrast and spectroscopic-based specificity of optical imaging with the high spatial resolution of ultrasound imaging. In essence, a PA image can be regarded as an ultrasound image in which the contrast depends not on the mechanical and elastic properties of the tissue, but its optical properties, specifically optical absorption. As a consequence, it offers greater specificity than conventional ultrasound imaging with the ability to detect haemoglobin, lipids, water and other light-absorbing chomophores, but with greater penetration depth than purely optical imaging modalities that rely on ballistic photons. As well as visualizing anatomical structures such as the microvasculature, it can also provide functional information in the form of blood oxygenation, blood flow and temperature. All of this can be achieved over a wide range of length scales from micrometres to centimetres with scalable spatial resolution. These attributes lend PA imaging to a wide variety of applications in clinical medicine, preclinical research and basic biology for studying cancer, cardiovascular disease, abnormalities of the microcirculation and other conditions. With the emergence of a variety of truly compelling in vivo images obtained by a number of groups around the world in the last 2 -3 years, the technique has come of age and the promise of PA imaging is now beginning to be realized. Recent highlights include the demonstration of whole-body small-animal imaging, the first demonstrations of molecular imaging, the introduction of new microscopy modes and the first steps towards clinical breast imaging being taken as well as a myriad of in vivo preclinical imaging studies. In this article, the underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.

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Section: Photoacoustic Tomography Imaging Systemsmentioning

confidence: 99%

Biomedical photoacoustic imaging

2011

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“…But the details of how METCAM mediates hematogenous or lymphatic spreading of melanoma cells have still yet to be investigated. Labeling the cells with viable dyes and following the process in real time by using a non-intruding, but highly photo-penetrating imaging method of photoacoustic tomography (PAT) [35][36] may be useful for monitoring each step in the METCAMmediated progression. For the METCAM-mediated dynamic spreading of melanoma cells in vivo, the PAT imaging method coupled with using hairless syngeneic mouse animal models [37] should reveal the process more clearly and in real time.…”

Section: Mechanisms Of Metcam-mediated Melanoma Progressionmentioning

confidence: 99%

“…To further understand its mechanisms in these processes, it is crucial to define its functional domains, identify its cognate ligand(s) and cofactor regulators, and study its cross-talk with members of various signaling pathways [7]. These model systems may be useful for real time observation of the dynamic process of cancer progression by using a non-intrusive and high photo-penetrating imaging system, such as the newly developed photoacoustic tomography (PAT), to further understanding the process in mouse models [35][36]. The knowledge gained would also be useful for designing effective means to decrease or even to block the metastatic potential of these cancers.…”

Section: Conclusion and Clinical Applicationsmentioning

confidence: 99%

Dual Roles of the Melanoma CAM (MelCAM/METCAM) in Malignant Progression of Melanoma

Wu¹

2011

Research on Melanoma - A Glimpse Into Current Directions and Future Trends

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“…PAT combines high ultrasonic resolution and strong optical contrast in a single modality, capable of providing both structural and functional images [18,19]. PAT has been used to in vivo image cerebral hemodynamics in small animals [20][21][22][23][24][25]. In this study, PAT is used to in vivo image neurovasculature and hemodynamics of cerebral hypoperfusion during acupuncture.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic imaging of cerebral hypoperfusion during acupuncture

Chen

Yang

et al. 2015

Biomed. Opt. Express

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Using acupuncture to treat cerebral hypoperfusion is a hot topic. However, there is a lack of effective tools to clarify the therapeutic effect of acupuncture on cerebral hypoperfusion. Here, we show in a mouse model of cerebral hypoperfusion that photoacoustic tomography (PAT) can noninvasively image cerebral vasculature and track total hemoglobin (HbT) concentration changes in cerebral hypoperfusion with acupuncture stimulation on the YangLingQuan (GB34) point. We measured the changes of HbT concentration and found that the HbT concentration in hypoperfusion regions was clearly lower than that in the control regions when the acupuncture was absent; however, it was significantly increased when the acupuncture was implemented on the GB34 point. We also observed the increase of vessel size and the generation of new vessels in cerebral hypoperfusion during acupuncture. Laser speckle imaging (LSI) was employed to validate some of the PAT findings. #241512Received 22

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Non-invasive imaging of epileptic seizuresin vivousing photoacoustic tomography

Cited by 73 publications

References 20 publications

Biomedical photoacoustic imaging

Biomedical photoacoustic imaging

Dual Roles of the Melanoma CAM (MelCAM/METCAM) in Malignant Progression of Melanoma

Photoacoustic imaging of cerebral hypoperfusion during acupuncture

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