Non-invasive fractional flow reserve (FFRCT) in the evaluation of acute chest pain – Concepts and first experiences

Abstract

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Combination of coronary CT angiography, FFRCT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD

“…Thus, further stratification and refinement in diagnostic and prognostic assessments are necessary, and invasive coronary angiography and invasive FFR are often performed. As a noninvasive test following CCTA, FFR CT assesses functional severity by utilizing computational fluid dynamics to calculate coronary blood flow, and exhibits good correlation with invasive FFR 16 . The utility of FFR CT has been demonstrated in several studies of patients with suspected CAD and CAS, and FFR CT ≤0.80 was used as a predictive indicator with functional significance 16‐18 .…”

“…As a noninvasive test following CCTA, FFR CT assesses functional severity by utilizing computational fluid dynamics to calculate coronary blood flow, and exhibits good correlation with invasive FFR. 16 The utility of FFR CT has been demonstrated in several studies of patients with suspected CAD and CAS, and FFR CT ≤0.80 was used as a predictive indicator with functional significance. 16 , 17 , 18 Data on clinical outcomes in association with FFR CT are limited compared to the diagnostic data.…”

“… 16 The utility of FFR CT has been demonstrated in several studies of patients with suspected CAD and CAS, and FFR CT ≤0.80 was used as a predictive indicator with functional significance. 16 , 17 , 18 Data on clinical outcomes in association with FFR CT are limited compared to the diagnostic data. Therefore, the FFR CT analysis was performed in patients with CAS determined using CCTA among a cohort of patients with suspected CAD in the present study, and the utility of FFR CT in predicting downstream clinical outcomes was examined.…”

Predictive Value of the HEART Score Combined with Hypersensitive C-Reactive Protein for 30 d Adverse Cardiovascular Events in Patients with Acute Chest Pain

“…Therefore, timely identification of the risk of chest pain and assessment of the patient's prognosis are conducive to guiding clinical treatment and improving the survival rate and are of great value for improving the prognosis [ 5 ]. In addition, due to the lack of accurate symptom manifestations of acute chest pain and the mostly atypical ECG, the optimal treatment time is easily missed, and sudden cardiac events are possible [ 6 ]. Therefore, how to rapidly predict MACE in acute chest pain has become an urgent clinical problem to be explored.…”

The Radiologist as a Gatekeeper in Chest Pain

“…New CCTA applications in the areas of perfusion and fractional flow reserve are on the horizon and are set to expand the diagnostic utility of cardiac CT [ 36 , 76 , 77 , 78 ]. In addition, beyond the evaluation of the degree of coronary stenosis, CT is being proposed as a method for evaluating the morphologies, composition, and vulnerability of atherosclerotic plaques with new potential for using radiomics in this field and artificial intelligence to predict patient outcome [ 79 , 80 , 81 , 82 ].…”