Non-invasive endothelial function testing and the risk of adverse outcomes: a systematic review and meta-analysis

Xu, Yang; Arora, Rakesh C.; Hiebert, Brett; Lerner, Blake; Szwajcer, Andrea; McDonald, Kerry S.; Rigatto, Claudio; Komenda, Paul; Sood, Manish M.; Tangri, Navdeep

doi:10.1093/ehjci/jet256

Cited by 227 publications

(186 citation statements)

References 50 publications

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“…In addition, reductions of 1 mmol in LDL-cholesterol have been associated with a 23% reduction in myocardial infarction or coronary death and 12% reduction in all-cause mortality [39]. In relation with our findings on FMD, several recent systematic reviews and metaanalysis indicate that increases in FMD of 1% increase, independently of confounding factors, are associated with reductions ranging from 10-13% in the risk of cardiovascular events [40][41][42].…”

Section: Implications For Health and Future Researchsupporting

confidence: 77%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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Section: Implications For Health and Future Researchsupporting

confidence: 77%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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“…Parameters measured by arterial tonometry have been found to be associated with the left ventricular hypertrophy, 35 CVD risk factors, 36 CVD events, 37,38 and all-cause mortality. 37,38 Accuracy of arterial tonometry is comparable to traditional invasive vascular testing methods. 39 However, further research is needed before it can be widely used in a clinical setting.…”

Section: Noninvasive Vascular Testing Measuresmentioning

confidence: 99%

Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Enkhmaa

Wall

Mehta

et al. 2016

Journal of Women's Health

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Preeclampsia affects *3%-7% of all pregnancies and is the third leading cause of maternal mortality globally. Growing evidence indicates that preeclampsia results from vascular dysfunction, which also increases the risk for future cardiovascular events. Until recently, preeclampsia was considered a disorder limited to pregnancy, which fully resolved with the delivery of the placenta; however, it is now clear that women with a history of preeclampsia have approximately double the risk of future cardiovascular events compared to women with normotensive pregnancies. The aims of this review were to describe the hemodynamic and vascular changes that occur in normal and preeclamptic pregnancies, to review noninvasive methods to test vascular function, and to discuss the associated increased cardiovascular disease risk related to preeclampsia.

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“…One approach is to evaluate the endothelial NO-availability by assessing the flow-induced and NO-dependent vasodilation (using the FMD test, for instance). It appears that the impairment of such a response, dubbed "endothelial dysfunction", correlates with the presence and the progression of various forms of CVD, and that the measures preventing CVD also reduce the endothelial dysfunction [24,27], supporting the view that disrupted endothelial homeostasis underlies the mechanism of CVD.…”

Section: Nitric Oxide and Ros Interactions Vs The Pro-atherosclerotimentioning

confidence: 98%

Enjoy your heart-beets. The role of dietary inorganic nitrate in cardiovascular health

Beresewicz

Gajos-Draus

2016

Kardiol Pol

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Non-invasive endothelial function testing and the risk of adverse outcomes: a systematic review and meta-analysis

Abstract: Brachial FMD and PAT are independent predictors of CV events and all-cause mortality. Further research to evaluate the prognostic utility of PAT is necessary to compare it with FMD as a non-invasive endothelial function test in clinical practice.

Cited by 227 publications

References 50 publications

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk

Enjoy your heart-beets. The role of dietary inorganic nitrate in cardiovascular health

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