Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers

Abstract

Advanced statistical analysis of a panel of six selected plasma biomarkers on samples obtained during the secretory phase or during menstruation allows the diagnosis of both minimal-mild and moderate-severe endometriosis with high sensitivity and clinically acceptable specificity.

Circulating and peritoneal fluid interleukin-6 levels and gene expression in pelvic endometriosis

“…Others have suggested that an association of serum markers may increase diagnostic accuracy (13,18). The observations recorded in the current study are in accordance with those reported by Kalu et al (30), which did not detect any differences in the serum IL-6 levels of patients with endometriosis • Outlier values.…”

“…Different serum markers have been established that may identify patients in the initial stages of endometriosis, when ablation or excision of lesions improves reproductive outcomes (11)(12)(13)(14)(15)(16)(17)(18). Among these markers, IL-6 appears to present good discriminatory power (11,14,17).…”

“…Among these markers, IL-6 appears to present good discriminatory power (11,14,17). In turn, other studies have demonstrated that combined analyses of different serum markers may improve the accuracy of endometriosis diagnosis (12,13,15,16,18), however no highly accurate marker for endometriosis has yet been detected. Therefore, the present study aimed to evaluate IL-6 levels in serum and PF, as well as IL-6 gene expression in subcutaneous and visceral fat, and in the eutopic and ectopic endometrium of patients with pelvic endometriosis.…”

Correlação entre os níveis de Ca-125 séricos e os achados cirúrgicos em mulheres com sintomas sugestivos de endometriose

“…Outros autores 16 sugerem que a realização de um painel de 6 marcadores plasmáticos (interleucina 6, O presente estudo confirma os achados dos estudos supracitados, mostrando uma correlação importante dos níveis elevados de Ca-125 (≥35 U/mL) em mulheres portadoras de sintomas sugestivos de endometriose com a presença de endometrioma ovariano e formas severas da doença. A importância dos achados deste estudo diz respeito à correlação entre a dosagem pré-operatória elevada de Ca-125 (≥35 U/mL) e a presença de EPI, quando o exame de imagem pré-operatório não identifica endometriose ovariana.…”

CA-125 concentration in serum and peritoneal fluid in patients with endometriosis – preliminary results

“…He proved that plasma levels of IL-6, IL-8 and CA-125 were increased in all women with endometriosis compared with the control group. More important is the fact that the elevated concentration of mentioned cytokines and CA-125 was statistically significant in minimal-mild endo metriosis compared with the control group [14].…”