Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

He, Yue; Yang, Majun; Cui, Jingyi; Zhao, Can; Jiang, Bin; Guan, Jiayun; Zhou, Xiaobo; He, Miao; Zhen, Yaya; Zhang, Yuxue; Jing, Rongrong; Wang, Qi; Qin, Yuling; Wu, Li

doi:10.1039/d3sc06866h

Chem. Sci.

2024

DOI: 10.1039/d3sc06866h

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Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

Yue He,

Majun Yang,

Jingyi Cui

et al.

Abstract: Bacterial infections, as the second leading cause of global death, are commonly treated with antibiotics. However, the improper use of antibiotics contributes to the development of bacterial resistance. Therefore, the...

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Cited by 2 publications

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Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Yoo,

Kim,

Lee

2024

Bulletin Korean Chem Soc

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Hydrogen sulfide (H2S) and nitroreductases (NTR) are key biological reductants, with H2S acting as a key signaling molecule and NTR reducing nitro groups to amines in cellular metabolism. Visualizing these reducing components, often overexpressed in cancer cells or bacterial environments, is crucial for metabolic understanding. Existing fluorescent probes detect these individually, but simultaneous detection methods are unexplored. We designed probe 1, which shows high fluorescence only when both NTR and H2S are overexpressed. The probe transformed into benzothiazole‐fused coumarin by NTR, exhibiting fluorescence, and shows a stronger signal in the presence of both NTR and H2S, making it a potential tool for detecting their simultaneous overexpression.

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Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Yoo,

Kim,

Lee

2024

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

show abstract

Ultra-sensitive and fast nitroreductase-responsive fluorescence probe for real-time bioimaging of hypoxia in tumor cells and zebrafish wound inflammation

An,

Sun,

Wang

et al. 2024

Sensors and Actuators B: Chemical

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Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

Abstract: Bacterial infections, as the second leading cause of global death, are commonly treated with antibiotics. However, the improper use of antibiotics contributes to the development of bacterial resistance. Therefore, the...

Cited by 2 publications

References 42 publications

Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Ultra-sensitive and fast nitroreductase-responsive fluorescence probe for real-time bioimaging of hypoxia in tumor cells and zebrafish wound inflammation

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