Non-invasive diagnosis and follow-up of chronic infection with hepatitis B virus

Leroy, Vincent; Chevaliez, Stéphane; Decraecker, Marie; Roulot, Dominique; Nana, Jean; Asselah, Tarik; Causse, Xavier; Durantel, David; Thibaut, V; Ganne-Carrié, Nathalie; Bureau, Christophe; Lédinghen, Victor de; Bourlière, Marc

doi:10.1016/j.clinre.2021.101773

Cited by 6 publications

(7 citation statements)

References 41 publications

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“…Upon examining the HBV cohort, we observed a consistent increase in liver stiffness up to the point of intervention with treatment. This trend aligns well with existing literature on the subject [18,19].…”

Section: Discussionsupporting

confidence: 91%

The Prevalence of Liver Fibrosis Stages on More than 23,000 Liver Stiffness Measurements by Vibration-Controlled Transient Elastography: A Single Center Study

Lazar,

Sporea,

Lungeanu

et al. 2023

Diagnostics

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Vibration-controlled transient elastography (VCTE) was the first non-invasive method used for assessing liver fibrosis in patients with chronic liver disease. Over the years, many studies have evaluated its performance. It is now used globally, and, in some countries, it represents the primary step in evaluating liver fibrosis. The aim of this study is to assess the feasibility of VCTE and highlight the prevalence of liver fibrosis stages assessed by VCTE in a large cohort of patients at a single study center. We also aimed to observe the trends in liver stiffness (LS) values over the years according to each type of hepatopathy. A retrospective study was conducted over a period of 13 years (2007–2019) and included patients who presented to our clinic for LS measurements (LSMs), either with known liver diseases or with suspected liver pathology who were undergoing fibrosis screening. The database contained a total of 23,420 measurements. Valid LSMs were obtained in 90.91% (21,291/23,420) of the cases, while 2129 (9.09%) of the measurements were either failed or unreliable. In untreated patients with chronic viral hepatitis, LS values tended to increase during the years, while in patients undergoing antiviral therapy LS values significantly decreased. Our comprehensive study, one of the largest of its kind spanning 13 years, emphasizes the reliability and significance of VCTE in real-world clinical settings.

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Section: Discussionsupporting

confidence: 91%

The Prevalence of Liver Fibrosis Stages on More than 23,000 Liver Stiffness Measurements by Vibration-Controlled Transient Elastography: A Single Center Study

Lazar,

Sporea,

Lungeanu

et al. 2023

Diagnostics

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“…The liver biopsy unfortunately invasive, remains the ‘gold standard’ in HBV/HDV co-infection [22]. In our survey, it was used by a majority of the respondents (81%).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Delta: assessment of the knowledge and practices of hepato-gastroenterologists practicing in non-academic settings in France

Cadranel,

Zougmoré,

Efole

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Background Data on the management of Hepatitis B-Delta (HB-D) by hepatogastroenterologists (HGs) practicing in nonacademic hospitals or private practices are unknown in France. Objective We aimed to evaluate the knowledge and practices of HGs practicing in nonacademic settings regarding HB-D. Methods A Google form document was sent to those HGs from May to September 2021. Results A total of 130 HGs (mean age, 45 years) have participated in this survey. Among HBsAg-positive patients, Delta infection was sought in only 89% of cases. Liver fibrosis was assessed using FibroScan in 77% of the cases and by liver biopsy in 81% of the cases. A treatment was proposed for patients with >F2 liver fibrosis in 49% of the cases regardless of transaminase levels and for all the patients by 39% of HGs. Responding HGs proposed a treatment using pegylated interferon in 50% of cases, bulevirtide in 45% of cases and a combination of pegylated interferon and bulevirtide in 40.5% of cases. Among the criteria to evaluate the treatment efficacy, a decrease or a normalization of transaminases was retained by 89% of responding HGs, a reduction of liver fibrosis score for 70% of them, an undetectable delta RNA and HBsAg for 55% of them and a 2 log 10 decline in delta viremia for 62% of the cases. Conclusion Hepatitis Delta screening was not systematically performed in HBsAg-positive patients despite the probable awareness and knowledge of the few responders who were able to prescribe treatments of hepatitis delta.

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“…Karaciğerin daha geniş bir kısmı değerlendirildiği için biyopsiye göre daha fazla bilgi vermektedir. Sonuçlar kilopascal (kPa) olarak verilir; 6 kPa ve altında olan sonuçlar sirozu dışlarken 9 kPa üzeri olan veya 12 kPa üzeri olan ve ALT yüksekliği olan durumlar kuvvetle ileri düzey karaciğer hastalığı olduğunu gösterir (74,75).…”

Section: "Transient" Elastografi (Fibroscan)unclassified

“…DNA düzeyleri izlenmeli, tanısı doğrulandıktan sonra daha uzun aralıklarla izlem sürdürülmelidir. Eğer yapılabiliyorsa HBsAg düzeyi bakılması da bu iki hasta grubunun ayırt edilmesinde yardımcı olacaktır(74,80). Tedavi alan HBeAg negatif ya da pozitif KHB hepatit olgularında; HBV DNA negatifliği elde edilene dek her üç ayda bir, negatiflik elde edildikten sonra altı ayda bir ALT ve HBV DNA takibi yapılmalıdır.…”

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2023

Klimik Derg

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Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Derneği Viral Hepatit Çalışma Grubu tarafından, ilki 2014 yılında yayımlanan kronik hepatit B (KHB) yönetimine ilişkin uzlaşı raporunun, infeksiyonun seyrinde yeniden oluşturulan evrelendirmeler, tedavi endikasyonlarındaki değişiklikler, tanı ve tedavi takibinde kullanılan yeni biyobelirteçler ve henüz günlük kullanıma girmese de tedavisindeki yeni gelişmeler nedeni ile güncellenme ihtiyacı doğmuştur. Bu nedenle güncel literatür ve uluslararası kanıta dayalı rehberler gözden geçirilerek yeni bir uzlaşı raporu hazırlanmıştır. Güncellenen uzlaşı raporumuzun, halen ülkemizde önemli bir sorun olan KHB için başvurulabilecek yararlı bir kaynak olacağını umuyoruz.

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Non-invasive diagnosis and follow-up of chronic infection with hepatitis B virus

Cited by 6 publications

References 41 publications

The Prevalence of Liver Fibrosis Stages on More than 23,000 Liver Stiffness Measurements by Vibration-Controlled Transient Elastography: A Single Center Study

The Prevalence of Liver Fibrosis Stages on More than 23,000 Liver Stiffness Measurements by Vibration-Controlled Transient Elastography: A Single Center Study

Hepatitis B Delta: assessment of the knowledge and practices of hepato-gastroenterologists practicing in non-academic settings in France

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