Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin  SPECT

Abstract

The study indicates the suitability of [(123)I]MIH for in vivo visualization of myocardial infarcts.

Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction

“…In nuclear imaging, high signal to background ratios are mandatory for accurate visualization and quantification of I-Hyp/Hyp mixture has shown excellent properties as a cardiac diagnostics due to its unique and selective necrosis avidity (Fonge et al, 2008;Cona et al, 2013b). However, its marked lipophilicity and consequent poor solubility in water is a common limitation in parenteral tracer formulation.…”

“…This animal model of infarction was chosen because it has been routinely used to prove the potential application of 123 I-Hyp as diagnostic cardiac agent showing reproducible and accurate results (Fonge et al, 2008;Feng et al, 2013;Cona et al, 2013a). As carrier of 123 I-Hyp/ Hyp, NaCh solutions at different concentrations were prepared for evaluating their solubilizing properties.…”

“…123 I-Hyp has emerged as a potent necrosis avid agent due to its notable long-lasting uptake in necrotic tissues (Ni et al, 2005(Ni et al, , 2006, making it a potential single-photon emission computed tomography (SPECT) agent for detection and quantification of acute myocardial infarction (AMI) (Fonge et al, 2008;Cona et al, 2013a). Contrary to conventional drug chemistry, radiopharmacy involves tiny amount of tracers that emit sufficient radiations to generate desired diagnostic signals.…”

Comparison of Reconstruction Methods in a Small Animal Cardiac Positron Emission Tomography Study Using a 18F-Labeled Myocardial Agent, [18F] FPTP

“…The infarct area was defined as any area with a perfusion value of 60% or less (19)(20)(21). Correlations were calculated, between defect sizes for the TTC and polar maps.…”

Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging

“…4 However, the long plasma half-life and high blood pool activity make it impossible for early in vivo visualization of necrotic myocardium. 5,6 To seek for superior necrosis avid agents in imaging, we further evaluated the necrosis targetability of monomeric anthraquinones. The results showed that monomeric anthraquinones exhibited necrosis targetability and shorter plasma half-life times.…”