Non-invasive continuous EEG-fNIRS recording of temporal lobe seizures

Nguyen, Dang Khoa; Tremblay, Julie; Pouliot, Philippe; Vannasing, Phetsamone; Florea, Olivia; Carmant, Lionel; Leporé, Franco; Sawan, Mohamad; Lesage, Frédéric; Lassonde, Maryse

doi:10.1016/j.eplepsyres.2011.10.035

Cited by 72 publications

(80 citation statements)

References 53 publications

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“…48,49 NIRS and electroencephalography (EEG) were successfully applied simultaneously to the mouse brain to spatiotemporally track hemodynamics responses to epileptic episodes that had been induced pharmacologically. 50 Another study combining NIRS and EEG has also revealed complex local and distant oxygenation changes during temporal-lobe seizures, 51 and so this methodology can be expected to be actively used in clinical researches. Epilepsy often occurs in the cerebral cortex, which makes it is easier to apply NIRS compared to other diseases that occur in deep brain areas.…”

Section: Epilepsymentioning

confidence: 99%

“…50 Another study combining NIRS and EEG has also revealed complex local and distant oxygenation changes during temporal-lobe seizures, 51 and so this methodology can be expected to be actively used in clinical researches. Epilepsy often occurs in the cerebral cortex, which makes it is easier to apply NIRS compared to other diseases that occur in deep brain areas.…”

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confidence: 99%

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Application of near-infrared spectroscopy in clinical neurology

Kim

Bae

2018

Ann Clin Neurophysiol

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Near-infrared spectroscopy (NIRS) monitoring has been used mainly to detect reduced perfusion of the brain during orthostatic stress in order to assess orthostatic intolerance (OI). Many studies have investigated the use of NIRS to reveal the pathophysiology of patients with OI. Research using NIRS in other neurological diseases (e.g., stroke, epilepsy, and migraine) is continuing. NIRS may play an important role in monitoring the regional distribution of the hemodynamic flow in real time and thereby reveal the underlying pathophysiology and facilitate the management of not only patients with OI symptoms but also those with various neurological diseases.Key words: Orthostatic intolerance; Near-infrared spectroscopy; Clinical neurology INTRODUCTIONMany studies have investigated the hemodynamics and functions of the brain in various fields.1 Several noninvasive methods have been introduced in recent decades for measuring neuronal activity in the brain. 2 Neurophysiological techniques such as electroencephalography, magnetoencephalography, and event-related potentials offer the ability to measure overall changes in the electromagnetic field with an excellent time resolution, but these methods have poor spatial resolution. On the other hand, brain imaging techniques such as positron-emission tomography (PET) and functional magnetic resonance imaging (fMRI) have greatly increased our knowledge about neural circuitry. However, PET is highly sensitive to motion artifacts, confines the patient, and involves the injection of radioactive materials. Although fMRI is noninvasive and has excellent spatial resolution, it is expensive, highly sensitive to motion artifacts, and difficult to integrate with other imaging modalities. 3,4 Near-infrared spectroscopy (NIRS) was introduced as a new neuroimaging modality for Principle of NIRSNIRS is a noninvasive optical imaging tool for observing changes in the hemodynamics in the prefrontal area that is based on measuring the concentrations of HbO and HbR in the blood. Since Franz Jöbsis first studied the oxygenation of living tissues, NIRS has been extensively applied in imaging studies of brain activation. 6 The physiological activation of neurons leads to an imbalance between oxygen supply and utilization, increasing the concentration of HbO and decreasing the concentration of HbR. Most tissues are relatively transparent to light in the near-infrared range from 700 to 900 nm, and photons interact with tissues via absorption and scattering. This means that near-infrared light is less absorbed and scattered by tissue than is light at other wavelengths. 7 This range of wavelengths is often called an optical window since the light can easily pass through most tissues; however, it is reflected by HbO and HbR, and hence the absorption and scattering of light used for NIRS can provide information relevant to neural activity. 8 This light penetrates several centimeters through tissue and can still be detected (Fig. 1). The NIRS system consists of a light source and a photodetector. The l...

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Section: Epilepsymentioning

confidence: 99%

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confidence: 99%

Application of near-infrared spectroscopy in clinical neurology

Kim

Bae

2018

Ann Clin Neurophysiol

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“…It is increasingly recognized that focal IEDs or seizures generate various hemodynamic changes in areas contiguous, contralateral or remote from the epileptic focus, observable on EEG-fNIRS, EEG-fMRI and SPECT studies (Lee et al, 2000;Huberfeld et al, 2006;Kobayashi et al, 2006;Zijlmans et al, 2011;Nguyen et al, 2012Nguyen et al, , 2013. This EEG-fNIRS study of IEDs was no different: in the 18 patients who already had significant HbR responses near the focus, similar HbR activations in the corresponding area of the contralateral lobe, were seen in 11 patients (61%, see Table.2; 50% for HbO/HbT, see Appendices A and B).…”

Section: Remote Hemodynamic Responsesmentioning

confidence: 99%

“…A detailed description of the EEG-fNIRS recording process can be found in Nguyen et al (2012). Briefly, custom helmets for different head sizes were designed to mount 64 fibered light sources and up to 16 detectors, as well as 19 carbon EEG electrodes onto the patient heads.…”

Section: Simultaneous Eeg-fnirs Recordingmentioning

confidence: 99%

fNIRS-EEG study of focal interictal epileptiform discharges

et al. 2014

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Functional near-infrared spectroscopy (fNIRS) acquired with electroencephalography (EEG) is a relatively new non-invasive neuroimaging technique with potential for long term monitoring of the epileptic brain. Simultaneous EEG-fNIRS recording allows the spatio-temporal reconstruction of the hemodynamic response in terms of the concentration changes in oxyhemoglobin (HbO) and deoxy-hemoglobin (HbR) associated with recorded epileptic events such as interictal epileptic discharges (IEDs) or seizures. While most previous studies investigating fNIRS in epilepsy had limitations due to restricted spatial coverage and small sample sizes, this work includes a sufficiently large number of channels to provide an extensive bilateral coverage of the surface of the brain for a sample size of 40 patients with focal epilepsies. Topographic maps of significant activations due to each IED type were generated in four different views (dorsal, frontal, left and right) and were compared with the epileptic focus previously identified by an epileptologist.After excluding 5 patients due to the absence of IEDs and 6 more with mesial temporal foci too deep for fNIRS, we report that significant HbR (respectively HbO) concentration changes corresponding to IEDs were observed in 62% (resp. 38%) of patients with neocortical epilepsies. This HbR/HbO response was most significant in the epileptic focus region among all the activations in 28%/21% of patients. Keywords:Focal epilepsy, fNIRS, NIRS-SPM, EEG, interictal epileptic discharges

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“…As a result, such an approach has been taken to examine cerebral hemodynamic changes occurring in patients with epilepsy. [1][2][3][4][5][6][7][8][9] As data are recorded for longer durations in these instances, this raises additional challenges to be addressed during and after data collection such as an increased prevalence of movement, which can induce artifacts in NIRS data. Recently, more attention has been given to the reduction of motion artifacts in NIRS data.…”

Section: Introductionmentioning

confidence: 99%

Artifact reduction in long-term monitoring of cerebral hemodynamics using near-infrared spectroscopy

et al. 2015

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Abstract. Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging technique used to assess cerebral hemodynamics. Its portability, ease of use, and relatively low operational cost lend itself well to the long-term monitoring of hemodynamic changes, such as those in epilepsy, where events are unpredictable. Long-term monitoring is associated with challenges including alterations in behaviors and motion that can result in artifacts. Five patients with epilepsy were assessed for interictal hemodynamic changes and alterations in behavior or motion. Based on this work, visual inspection was used to identify NIRS artifacts during a period of interest, specifically prior to seizures, in four patients. A motion artifact reduction algorithm (MARA, also known as the spline interpolation method) was tested on these data. Alterations in the NIRS measurements often occurred simultaneously with changes in motion and behavior. Occasionally, sharp shift artifacts were observed in the data. When artifacts appeared as sustained baseline shifts in the data, MARA reduced the standard deviation of the data and the appearance improved. We discussed motion and artifacts as challenges associated with longterm monitoring of cerebral hemodynamics in patients with epilepsy and our group's approach to circumvent these challenges and improve the quality of the data collected.

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Non-invasive continuous EEG-fNIRS recording of temporal lobe seizures

Cited by 72 publications

References 53 publications

Application of near-infrared spectroscopy in clinical neurology

Application of near-infrared spectroscopy in clinical neurology

fNIRS-EEG study of focal interictal epileptiform discharges

Artifact reduction in long-term monitoring of cerebral hemodynamics using near-infrared spectroscopy

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