Non-invasive bronchial epithelial papillary tumors

Abstract

Nineteen papillary, non-invasive tumors arising from the bronchial epithelium but excluding carcinoid tumors are reviewed. Eight were solitary papillomas of which three were covered with a mixture of epithelial types. Seven were benign but one had a focus of carcinoma in situ. A similar change was seen in bronchial epithelium adjacent to a papilloma. Two cases of recurrent papillomas were seen and in one, carcinomatous changes eventually occurred. Two combined benign brochial cystadenomas with papillomas are described. One transitional celled papillary carcinoma in situ and five other papillary carcinomas in situ are described. One bronchial papilloma covered with dysplastic epithelium was considered an intermediate stage in the development of carcinoma in situ. Two papillary tumors may have arisen from peripheral bronchi or brochioles. Their lining cells resembled Clara cells, they grew by local expansion, and there was an absence of malignant features. The differential characteristics of two secondary carcinomatous polypoidal tumors are described.

A Solitary Mixed Squamous Cell and Glandular Papilloma of the Lung

“…In previous reports, 5 mixed papillomas had malignant features (squamous cell carcinoma in situ in 2 cases, adenocarcinoma in 1, lowgrade differentiation cells of carcinoma in 1, and pleomorphic carcinoma in 1). 1,2,6,8) The putative risk factors for malignant transformation are smoking and human papillomavirus (HPV) infection. Given that HPV was detected in squamous cell papilloma but not in mixed papilloma (0 of 9 cases), smoking status might play more important role in the malignant transformation of mixed papilloma.…”

“…Thus far, only 18 cases have been reported in the English literature. [1][2][3][4][5][6][7][8][9] The incidence of mixed papilloma has a male sex predilection (16:3), and most (75%) …”

Glandular papilloma of the lung with malignant transformation

“…Solitary pulmonary papillomas are known as rare benign endobronchial neoplasms that are usually derived from bronchial surface epitheliums [1][2][3]. They are accounted for only 0.38% of all lung tumors [5] and approximately 7% of all benign epithelial and mesenchymal lung tumors [6].…”

“…They are accounted for only 0.38% of all lung tumors [5] and approximately 7% of all benign epithelial and mesenchymal lung tumors [6]. At bronchoscopy, they appear as endobronchial masses, which cause narrowing of the airway lumen approximately 40% to 60% YUJM VOLUME 34, NUMBER 2, DECEMBER 2017 of its normal diameter [3,4]. Solitary pulmonary papillomas can be divided into three categories according to the epithelial cell histology: squamous cell papilloma, glandular papilloma, and mixed squamous cell and glandular papilloma (mixed papilloma) [2].…”

“…It is known as an uncommon neoplasm and most glandular papilloma arise from central lobar or segmental bronchi [1][2][3]. Few reports of pulmonary papillomas described arising in peripheral endobroncholar lesions.…”