Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer's disease: A pilot study

Eliasova, Ilona; Anderková, Ľubomíra; Mareček, Radek; Rektorová, Irena

doi:10.1016/j.jns.2014.08.036

Cited by 100 publications

(85 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Memory improvement was reported in 3 out of 5 studies targeting the temporal region [81-83, 85, 91]. According to the study by Antonenko et al [55] in healthy older subjects, atDCS targeting the temporo-parietal cortex resulted in better memory, and this improvement was associated with increased DMN connectivity.…”

Section: Nibs and Dementiamentioning

confidence: 99%

“…The type of treatment protocol used could be responsible of the different results reported, since one of those investigations tested whether combining NIBS with cognitive training leads to a pronounced enhancement of training effects [84]. On the other hand, DLPFC modulation seems effective in improving global cognition, language, and attention abilities in AD patients [86, 88, 89, 91]. Accordingly, the beneficial effects on non-memory abilities of NIBS over the frontal cortex may be related to modulation of other (non-DMN) networks.…”

Section: Nibs and Dementiamentioning

confidence: 99%

See 1 more Smart Citation

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

View full text Add to dashboard Cite

Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

show abstract

Section: Nibs and Dementiamentioning

confidence: 99%

Section: Nibs and Dementiamentioning

confidence: 99%

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is possible that the effects of non-invasive brain stimulation on cognitive function may be more prominent in older adults and in patients with Alzheimer’s disease since physiological and pathological aging show structural and functional alterations related to neural plasticity (Gutchess, 2014; Oberman and Pascual-Leone, 2013). Supporting this hypothesis, it appears that many studies have exhibited significant enhancement of cognitive function when non-invasive stimulation is applied in older adults (Ahmed et al, 2012; Boggio et al, 2012; Eliasova et al, 2014; Fertonani et al, 2014; Floel et al, 2012; Harty et al, 2014; Khedr et al, 2014; Manenti et al, 2013; Meinzer et al, 2013; Ross et al, 2011; Sandrini et al, 2014), whereas fewer studies have exhibited little to no beneficial effects (Boggio et al, 2010; Cotelli et al, 2014). The conflicting results along with differences in quality and methods across the studies make it difficult to reach a consensus regarding the effects of non-invasive brain stimulation on physiological and pathological aging-associated cognitive impairments.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have suggested that rTMS (Ahmed et al, 2012; Cotelli et al, 2006, 2008, 2011; Eliasova et al, 2014; Kim et al, 2012; Rabey et al, 2013; Sole-Padulles et al, 2006) or tDCS (Berryhill and Jones, 2012; Boggio et al, 2009, 2012; Cotelli et al, 2014; Ferrucci et al, 2008; Fertonani et al, 2014; Floel et al, 2012; Harty et al, 2014; Holland et al, 2011; Khedr et al, 2014; Manenti et al, 2013; Meinzer et al, 2013, 2014; Park et al, 2014; Ross et al, 2011; Sandrini et al, 2014) may have beneficial effects on various cognitive functions in healthy older adults and patients with AD. By applying a single session of rTMS or tDCS, studies have demonstrated that both of these techniques are capable of positively influencing cognitive functions among older participants (Berryhill and Jones, 2012; Fertonani et al, 2014; Floel et al, 2012; Harty et al, 2014; Kim et al, 2012; Manenti et al, 2013; Meinzer et al, 2013, 2014; Park et al, 2014; Ross et al, 2011; Sandrini et al, 2014; Sole-Padulles et al, 2006) and patients with AD (Ahmed et al, 2012; Boggio et al, 2009, 2012; Cotelli et al, 2006, 2008, 2011; Eliasova et al, 2014; Ferrucci et al, 2008; Khedr et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…By applying a single session of rTMS or tDCS, studies have demonstrated that both of these techniques are capable of positively influencing cognitive functions among older participants (Berryhill and Jones, 2012; Fertonani et al, 2014; Floel et al, 2012; Harty et al, 2014; Kim et al, 2012; Manenti et al, 2013; Meinzer et al, 2013, 2014; Park et al, 2014; Ross et al, 2011; Sandrini et al, 2014; Sole-Padulles et al, 2006) and patients with AD (Ahmed et al, 2012; Boggio et al, 2009, 2012; Cotelli et al, 2006, 2008, 2011; Eliasova et al, 2014; Ferrucci et al, 2008; Khedr et al, 2014). With multiple sessions of stimulation, long-term after-effects of these techniques have been found (Ahmed et al, 2012; Boggio et al, 2012; Cotelli et al, 2011; Khedr et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis

Hsu

Zanto

et al. 2015

Neurobiology of Aging

285

239

View full text Add to dashboard Cite

The study aimed to evaluate the effects of non-invasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer’s disease (AD). A comprehensive literature search was performed on non-invasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fourteen articles with a total of 331 participants were identified as studies with healthy older adults and the mean effect size and 95% confidence interval were estimated. A significant effect size of 0.42 was found for the cognitive outcome. Further subgroup analyses demonstrated more prominent effects for studies delivering the stimulation before the execution of the task and studies applying multiple sessions of stimulation. To assess effects of stimulation on AD patients, eleven studies with a total of 200 patients were included in the analysis. A significant effect size of 1.35 was found for the cognitive outcomes. Subgroup analyses indicated more pronounced effects for studies applying the stimulation during the execution of the task compared to studies delivering the stimulation before the execution of the task. Non-invasive brain stimulation has a positive effect on cognitive function in physiological and pathological aging.

show abstract

Transcranial magnetic stimulation cortical oscillations and improve cognition in obstructive sleep apnea patients

et al. 2023

View full text Add to dashboard Cite

Background Transcranial magnetic stimulation (TMS) is a noninvasive tool to improve cognition. Relevant clinical studies are mainly focused on neurological and psychiatric diseases. However, cognition decline and psychiatric disorders are popular in obstructive sleep apnea (OSA) patients. We aimed to investigate the effect of TMS over the left dorsolateral prefrontal cortex (DLPFC) on cognition test performance and to compare the changes in quantitative electroencephalogram (EEG) before and after stimulation for OSA. Methods This study recruited 42 OSA patients diagnosed with polysomnography according to American Academy of Sleep Medicine guidelines. TMS (intermittent theta‐burst stimulation paradigm; 2 s on, 8 s off, 600 pulses*3, intermittent 15 min) was performed on the DLPFC. Cambridge Automated Neuropsychological Test Battery was used to assess cognitive performance. EEG oscillations were computed via power spectral density with MATLAB software. Results Real‐TMS group displayed a significant improvement in visual memory, sustain attention performance, as well as the outcome of working memory. However, the executive function of latency was changed in both groups. Furthermore, TMS resulted in a significant increase in the relative power spectral density of the theta band and beta band in the parietal, temporal, and anterior regions, respectively. Conclusions In summary, our findings indicate that TMS can safely modulate cortical oscillations and improve cognition in OSA patients. In the future, TMS can be utilized as an alternative treatment option to improve cognition in OSA patients.

show abstract

Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer's disease: A pilot study

Cited by 100 publications

References 40 publications

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis

Transcranial magnetic stimulation cortical oscillations and improve cognition in obstructive sleep apnea patients

Contact Info

Product

Resources

About