Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

Kang, Nyeonju; Summers, Jeffery J.; Cauraugh, James H.

doi:10.1016/j.brs.2016.05.005

Cited by 51 publications

(29 citation statements)

References 66 publications

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“…1000 bootstrap samples of 15 and 30 individuals (i.e. 45,000 resamples in total) were analysed, reflecting sample sizes typically observed in tDCS studies [40,50]. Each iteration of resampling randomly drew individuals from the original sample (N=50) with replacement.…”

Section: Reproducibility Of Left M1 Intensities With Typical Sample-smentioning

confidence: 99%

“…With smaller sample sizes (~15-30 individuals) commonly used in basic and translational tDCS studies [40,50,53], this heterogeneity can result in cohorts with entirely different stimulation profiles. Bootstrapped samples illustrated that, on average, for smaller samples the overall intensities in left M1 can vary substantially from our larger population mean.…”

Section: Dose-control Reduces Variance In E-field Intensities At a Comentioning

confidence: 99%

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Dose-controlled tDCS reduces electric field intensity variability at a cortical target site

Evans

Bachmann

Lee

et al. 2019

Preprint

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Background: Variable effects limit the efficacy of transcranial direct current stimulation (tDCS) as a research and therapeutic tool. Conventional application of a fixed-dose of tDCS does not account for inter-individual differences in anatomy (e.g. skull thickness), which varies the amount of current reaching the brain. Individualised dose-control may reduce the variable effects of tDCS by reducing variability in electric field intensities at a cortical target site.Objective: To characterise the variability in electric field intensity at a cortical site (left primary motor cortex; M1) and throughout the brain for conventional fixed-dose tDCS, and individualised dose-controlled tDCS. Methods: The intensity and distribution of the electric field during tDCS was estimated using Realistic Volumetric Approach to Simulate Transcranial Electric Stimulation (ROAST) in 50 individual brain scans taken from the Human Connectome Project, for fixed-dose tDCS (1mA & 2mA) and individualised dose-controlled tDCS targeting left M1.Results: With a fixed-dose (1mA & 2mA), E-field intensity in left M1 varied by more than 100% across individuals, with substantial variation observed throughout the brain as well.Individualised dose-controlled ensured the same E-field intensity was delivered to left M1 in all individuals. Its variance in other regions of interest (right M1 and area underneath the electrodes) was comparable with fixed-and individualised-dose.Conclusions: Individualized dose-control can eliminate the variance in electric field intensities at a cortical target site. Assuming that the current delivered to the brain directly determines its physiological and behavioural consequences, this approach may allow for reducing the known variability of tDCS effects.

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Section: Reproducibility Of Left M1 Intensities With Typical Sample-smentioning

confidence: 99%

Section: Dose-control Reduces Variance In E-field Intensities At a Comentioning

confidence: 99%

Dose-controlled tDCS reduces electric field intensity variability at a cortical target site

Evans

Bachmann

Lee

et al. 2019

Preprint

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“…LF-rTMS has been shown to reduce interhemispheric inhibition and lead to an increased activation of the lesioned cortex in correlation with functional improvement in chronic stroke patients (Ayache et al 2012). A recent meta-analysis by Kang et al (2016) evaluated the efficacy of non-invasive brain stimulation techniques (rTMS and transcranial direct current stimulation (tDCS)) on improving force production capability in paretic limbs of stroke patients and concluded that tDCS and rTMS protocols (increasing cortical excitability in the ipsilesional hemisphere via anodal tDCS and HF-rTMS; and decreasing cortical excitability in the contralesional hemisphere via cathodal tDCS and LF-rTMS) successfully improved paretic limb force production capabilities. Based on these findings, we applied LF-rTMS to the unaffected primary motor cortex of chronic ischemic stroke patients in our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of low-frequency repetitive transcranial magnetic stimulation on upper extremity motor recovery and functional outcomes in chronic stroke patients: A randomized controlled trial

Aşkın

Demirdal

2017

Somatosensory & Motor Research

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“…In adults with stroke, TMS has been widely researched to assess or influence corticospinal excitability and reorganization [7,8,9,10]. In children with CP, NIBS can also be used for corticospinal excitability assessment [11,12,13,14,15,16,17], as well as a neuromodulatory intervention, to improve motor outcomes.…”

Section: Introductionmentioning

confidence: 99%

Corticospinal Excitability in Children with Congenital Hemiparesis

et al. 2016

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Transcranial magnetic stimulation (TMS) can be used as an assessment or intervention to evaluate or influence brain activity in children with hemiparetic cerebral palsy (CP) commonly caused by perinatal stroke. This communication report analyzed data from two clinical trials using TMS to assess corticospinal excitability in children and young adults with hemiparetic CP. The results of this communication revealed a higher probability of finding a motor evoked potential (MEP) on the non-lesioned hemisphere compared to the lesioned hemisphere (p = 0.005). The resting motor threshold (RMT) was lower on the non-lesioned hemisphere than the lesioned hemisphere (p = 0.013). There was a significantly negative correlation between age and RMT (rs = −0.65, p = 0.003). This communication provides information regarding MEP responses, motor thresholds (MTs) and the association with age during TMS assessment in children with hemiparetic CP. Such findings contribute to the development of future pediatric studies in neuroplasticity and neuromodulation to influence motor function and recovery after perinatal stroke.

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Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

Cited by 51 publications

References 66 publications

Dose-controlled tDCS reduces electric field intensity variability at a cortical target site

Dose-controlled tDCS reduces electric field intensity variability at a cortical target site

Effects of low-frequency repetitive transcranial magnetic stimulation on upper extremity motor recovery and functional outcomes in chronic stroke patients: A randomized controlled trial

Corticospinal Excitability in Children with Congenital Hemiparesis

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