Non-invasive brain stimulation and robot-assisted gait training after incomplete spinal cord injury: A randomized pilot study

Raithatha, Ravi; Carrico, Cheryl; Powell, Elizabeth; Westgate, Philip M.; Chelette, Kenneth C.; Lee, Kara; Dunsmore, Laura; Salles, Sara; Sawaki, Lumy

doi:10.3233/nre-151291

Cited by 60 publications

(91 citation statements)

References 68 publications

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“…16 There were mixed results, however, with other outcomes; participants in the sham group had greater change in some measures, including significantly greater improvements on the outcome measure related to functional independence. 16 …”

Section: Targeting Supraspinal Structuresmentioning

confidence: 96%

“…120 Two studies using transcranial direct current stimulation (tDCS) followed by locomotor training showed mixed results. 16,17 In nine subjects who received 36 sessions of tDCS, improvements in lower extremity motor scores of the right lower extremity were observed compared with six subjects who received sham-tDCS. 16 There were mixed results, however, with other outcomes; participants in the sham group had greater change in some measures, including significantly greater improvements on the outcome measure related to functional independence.…”

Section: Targeting Supraspinal Structuresmentioning

confidence: 96%

“…To date, three studies of this type have been published related to walking, [16][17][18] as well as a case study related to lower extremity muscle activity. 120 Two studies using transcranial direct current stimulation (tDCS) followed by locomotor training showed mixed results.…”

Section: Targeting Supraspinal Structuresmentioning

confidence: 99%

“…For this reason, recent studies have begun to target supraspinal control mechanisms in both animal models 12,13 and humans. [14][15][16][17][18] The increasing appreciation for the importance of supraspinal contributions to locomotor function in persons with SCI derives from studies that have shown the influence of volitional control on walking. Evidence is accumulating for the value of clinical measures of volitional control in predicting future walking function, in forecasting responsiveness to training, and delineating the variables that correlate with walking capacity.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Supraspinal Control Predicts Locomotor Function and Forecasts Responsiveness to Training after Spinal Cord Injury

Field-Fote

Yang

Basso

et al. 2017

Journal of Neurotrauma

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Restoration of walking ability is an area of great interest in the rehabilitation of persons with spinal cord injury. Because many cortical, subcortical, and spinal neural centers contribute to locomotor function, it is important that intervention strategies be designed to target neural elements at all levels of the neuraxis that are important for walking ability. While to date most strategies have focused on activation of spinal circuits, more recent studies are investigating the value of engaging supraspinal circuits. Despite the apparent potential of pharmacological, biological, and genetic approaches, as yet none has proved more effective than physical therapeutic rehabilitation strategies. By making optimal use of the potential of the nervous system to respond to training, strategies can be developed that meet the unique needs of each person. To complement the development of optimal training interventions, it is valuable to have the ability to predict future walking function based on early clinical presentation, and to forecast responsiveness to training. A number of clinical prediction rules and association models based on common clinical measures have been developed with the intent, respectively, to predict future walking function based on early clinical presentation, and to delineate characteristics associated with responsiveness to training. Further, a number of variables that are correlated with walking function have been identified. Not surprisingly, most of these prediction rules, association models, and correlated variables incorporate measures of volitional lower extremity strength, illustrating the important influence of supraspinal centers in the production of walking behavior in humans.

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Section: Targeting Supraspinal Structuresmentioning

confidence: 96%

Section: Targeting Supraspinal Structuresmentioning

confidence: 96%

Section: Targeting Supraspinal Structuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Supraspinal Control Predicts Locomotor Function and Forecasts Responsiveness to Training after Spinal Cord Injury

Field-Fote

Yang

Basso

et al. 2017

Journal of Neurotrauma

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“…Finally, combination of tDCS and robotic training has shown a promising strategy for improving arm, hand and lower extremity motor functions in persons with incomplete spinal cord injury (Raithatha et al, 2016; Yozbatiran et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Literature Review on the Effects of tDCS Coupled with Robotic Therapy in Post Stroke Upper Limb Rehabilitation

Simonetti

Zollo

Milighetti

et al. 2017

Front. Hum. Neurosci.

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Today neurological diseases such as stroke represent one of the leading cause of long-term disability. Many research efforts have been focused on designing new and effective rehabilitation strategies. In particular, robotic treatment for upper limb stroke rehabilitation has received significant attention due to its ability to provide high-intensity and repetitive movement therapy with less effort than traditional methods. In addition, the development of non-invasive brain stimulation techniques such as transcranial Direct Current Stimulation (tDCS) has also demonstrated the capability of modulating brain excitability thus increasing motor performance. The combination of these two methods is expected to enhance functional and motor recovery after stroke; to this purpose, the current trends in this research field are presented and discussed through an in-depth analysis of the state-of-the-art. The heterogeneity and the restricted number of collected studies make difficult to perform a systematic review. However, the literature analysis of the published data seems to demonstrate that the association of tDCS with robotic training has the same clinical gain derived from robotic therapy alone. Future studies should investigate combined approach tailored to the individual patient's characteristics, critically evaluating the brain areas to be targeted and the induced functional changes.

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Neurorehabilitation: Strategies of Lower Extremities Restoration

Hensel

Eck

Alimusaj

et al. 2017

Neurological Aspects of Spinal Cord Injury

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Non-invasive brain stimulation and robot-assisted gait training after incomplete spinal cord injury: A randomized pilot study

Abstract: Pairing tDCS with LT-RGO can improve lower extremity motor function more than LT-RGO alone. Future research with a larger sample size is recommended to determine longer-term effects on motor function and activities of daily living.

Cited by 60 publications

References 68 publications

Supraspinal Control Predicts Locomotor Function and Forecasts Responsiveness to Training after Spinal Cord Injury

Supraspinal Control Predicts Locomotor Function and Forecasts Responsiveness to Training after Spinal Cord Injury

Literature Review on the Effects of tDCS Coupled with Robotic Therapy in Post Stroke Upper Limb Rehabilitation

Neurorehabilitation: Strategies of Lower Extremities Restoration

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