Non-invasive biomarkers of chronic obstructive pulmonary disease

Анаев, Э. Х.; Anokhina, T.N.; Кушаева, М. Э.; Чучалин, А. Г.

doi:10.18093/0869-0189-2013-0-3-97-104

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Bronchial obstruction syndrome is the leading clinical feature of both diseases. Their specific features allow a simple differential diagnosis in most cases, especially at early stages [2,3]. However, the diagnosis is complicated considering the variety of asthma and COPD phenotypes and combination of signs of both diseases is several patients (smoking in asthma, high sputum eosinophilia, over 12% FEV1 increment on bronchodilator test in COPD, etc.).…”

Section: Introductionmentioning

confidence: 99%

“…However, the diagnosis is complicated considering the variety of asthma and COPD phenotypes and combination of signs of both diseases is several patients (smoking in asthma, high sputum eosinophilia, over 12% FEV1 increment on bronchodilator test in COPD, etc.). In recent years, practical medicine has searched for biological markers, such as hydrogen peroxide, nitric oxide, and eosinophil mediators (e.g., eosinophilic cationic protein) in exhaled air to establish a correct diagnosis [3,4]. Nevertheless, developments are extremely urgently needed to clarify the diagnosis and differentiate COPD from asthma.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Распопина¹,

Grigoryevich²,

Mustafaevich³

et al. 2021

AJIM

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Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Распопина¹,

Grigoryevich²,

Mustafaevich³

et al. 2021

AJIM

View full text Add to dashboard Cite

show abstract

Long-chain fatty acids and short-chain fatty acids in exhaled breath condensate of patients with chronic obstructive pulmonary disease

et al. 2021

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In present study we performed gas-liquid chromatographic analysis of exhaled breath condensate to measure volatile fatty acids (C2 — acetic, C3 — propionic, C4 — butanoic, isoC4 — isobutyric, C5 — valerianic, C6 — caproic, C7 — heptanoic) and fatty acid with a long aliphatic chain (C14:0 — myristic, C15:0 — pentadecanoic, C16:0 — palmitic, C16:1 — palmitooleic, C17:0 — heptadecanoic, C17:1 — heptadecenoic, C18:0 — stearic, C18:1 — oleic, C18:2 — linolenic, C18:3ω3 — α-linolenic, C20:4ω6 — arachidonic) in patients suffering from moderate chronic obstructive pulmonary disease (2nd stage, GOLD). We revealed the increase of the total amount of short chain fatty acids (C2, C3, C4, C5) and polyunsaturated (C18:2, C20:4ω6) fatty acids, meanwhile the level of saturated fatty acids (C16:0, C17:0, C18:0) decreased.

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Non-invasive biomarkers of chronic obstructive pulmonary disease

Cited by 2 publications

References 55 publications

Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Long-chain fatty acids and short-chain fatty acids in exhaled breath condensate of patients with chronic obstructive pulmonary disease

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