Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques

Liu, Peiying; Chalak, Lina F.; Lu, Hanzhang

doi:10.1016/j.earlhumdev.2014.06.009

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…Consequently, many of the neonatal brain injuries such as hypoxic ischemic encephalopathy (HIE) have been linked to a disruption of oxygen supply and metabolism (33). Therefore, the ability to measure CMRO2 in neonates may provide an important tool to diagnose brain injuries, bring mechanistic insights into the disease course, and guide therapy on an individual basis (34). Non-invasive MRI techniques have been proposed to measure blood T2 in vivo , and then convert blood T2 to blood oxygenation via the T2-Y calibration plot (12,13,26,30,31).…”

Section: Discussionmentioning

confidence: 99%

T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature

Liu

Chalak

Krishnamurthy

et al. 2015

Magnetic Resonance in Med

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Purpose Knowledge of blood T1 and T2 is of major importance in many applications of MRI in neonates. However, to date, there has not been a systematic study to examine neonatal blood T1/T2 relaxometry. This present study aims to investigate this topic. Methods Using freshly collected blood samples from human umbilical cord, we performed in vitro experiments under controlled physiological conditions to measure blood T1 and T2 at 3T and their dependence on several factors, including hematocrit (Hct), oxygenation (Y) and temperature. Results The arterial T1 in neonates was 1825±184ms (Hct=0.42±0.08), longer than that of adult blood. Neonatal blood T1 was strongly dependent on Hct (p<0.001) and Y (p=0.005), and the dependence of T1 on Y was more prominent at higher Hct. The arterial T2 of neonatal blood was 191ms at an Hct of 0.42, which was also longer than adult blood. Neonatal blood T2 was positively associated with blood oxygenation and negatively associated with hematocrit level, and can be characterized by an exchange model. Neonatal blood T1 was also positively associated with temperature (p<0.001). Conclusion The values provided in this report may provide important reference and calibration information for sequence optimization and quantification of in vivo neonatal MRI studies.

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Section: Discussionmentioning

confidence: 99%

T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature

Liu

Chalak

Krishnamurthy

et al. 2015

Magnetic Resonance in Med

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“…Клинические и экспериментальные исследования показали, что церебральный метаболизм как у взрослых, так и у новорожденных значительно возрастает во время парадоксального сна и его уровень сопоставим с таковым во время бодрствования [16,19]. Скорость поглощения кислорода мозговой тканью в REM-сне подобна таковой во время бодрствования и значительно выше, чем во время NREM-сна [18,28]. По мнению авторов, эндогенная активация нейрональных структур во время REM-сна обеспечивает развитие мозга так же, как и экзогенные сенсорные воздействия во время бодрствования [27].…”

Section: результаты исс ледований и обс у ж дниеunclassified

The feature of brain oxygenation in the sleep cycle of healthy newborn babies

et al. 2020

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Noninvasive monitoring brain oxygenation with near-infrared spectroscopy (NIRS) is becoming a widely used in neonatology for determine the optimal target oxygen saturation during resuscitation of newborns, but its use in clinical practice for diagnostics and prognosis perinatal pathology is limited because intra and especially interpatient variability are too large for this aim. This study aimed to determine cerebral oximetry values during the sleep cycle and wakefulness in healthy full term newborns. 38 newborns (gestational age 38 weeks were included in this study (22 after normal birth I group and 16 after cesarean section). Near-infrared spectroscopy (CrSO2) from left fronto-parietal region was recorded in synchrony with polysomnography. Continuous cerebral CrSO2 were measured using near-infrared spectroscopy (Somanetic INVOS 5100C, USA). Fraction tissue oxygen extraction (FTOE) was calculated using SaO2 (pulse oximeter Radical Masimo) and CrSO2 (FTOE = (SаO2 CrSO2)/SаO2). CrSO2 and SаO2 were analyzed during 15 minutes polysomnography-defined quiet, active sleep and wakefulness (defined according to standard guidelines). The results: cerebral oxygen saturation varies with sleep-wake states: during active sleep (74,18 0,75%) was similar to the value in wakefulness (75,6 1,0%) and smaller than in quiet sleep (81,93 1,74%, р 0,001), but FTOE during active sleep was significantly higher (0,221 0,008% and 0,129 0,005%, p 0,001). There were no differences of rates between groups. The high oxygen consumption during REM sleep supports its role during postnatal brain functional development. The use of NIRS taking into account sleep structure will be new method for diagnostic and prognosis perinatal pathology CNS.

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“…Disruption of oxygen supply to the fetus can lead to hypoxic‐ischemic injury, and result in postnatal developmental delays and deficits. For this reason, the ability of MRI to non‐invasively probe brain oxygenation and predict ischemia at gestational ages earlier than 36 weeks is important [see for instance, ]. Fetal imaging of oxygenation is challenging because of fetal motion, maternal breathing, and necessarily large field of views that lead to long scan times.…”

Section: Clinical Applications Of Susceptibility‐based Oximetry To Thmentioning

confidence: 99%

Susceptibility‐based time‐resolved whole‐organ and regional tissue oximetry

et al. 2016

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The magnetism of hemoglobin – being paramagnetic in its deoxy and diamagnetic in its oxy state – offers unique opportunities to probe oxygen metabolism in blood and tissues. The magnetic susceptibility χ of blood scales linearly with blood oxygen saturation, which can be obtained by measuring the magnetic field ΔB of the intravascular MR signal relative to tissue. In contrast to χ the induced field ΔB is non-local. Therefore, to obtain the intravascular susceptibility Δχ relative to adjoining tissue from the measured ΔB demands solution of an inverse problem. Fortunately, for ellipsoidal structures, to which a straight, cylindrically shaped blood vessel segment conforms, the solution is trivial. The article reviews the principle of MR susceptometry-based blood oximetry. It then discusses applications for quantification of whole-brain oxygen extraction – typically on the basis of a measurement in the superior sagittal sinus – and, in conjunction with total cerebral blood flow, the cerebral metabolic rate of oxygen (CMRO2). By simultaneously measuring flow and venous oxygen saturation (SvO2) a temporal resolution of a few seconds can be achieved, allowing the study of the response to nonsteady-state challenges such as volitional apnea. Extensions to regional measurements in smaller cerebral veins are also possible, as well as voxelwise quantification of venous blood saturation in cerebral veins accomplished by quantitative susceptibility mapping (QSM) techniques. Applications of susceptometry-based oximetry to studies of metabolic and degenerative disorders of the brain are reviewed. Lastly, the technique is shown to be applicable to other organ systems such as the extremities using SvO2 as a dynamic tracer to monitor the kinetics of the microvascular response to induced ischemia.

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Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques

Cited by 19 publications

References 43 publications

T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature

T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature

The feature of brain oxygenation in the sleep cycle of healthy newborn babies

Susceptibility‐based time‐resolved whole‐organ and regional tissue oximetry

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