Non‐invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy

Lacourpaille, Lilian; Hug, François; Guével, Arnaud; Péreón, Yann; Magot, Armelle; Hogrel, Jean‐Yves; Nordez, Antoine

doi:10.1002/mus.24445

Cited by 95 publications

(77 citation statements)

References 19 publications

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“…During the past few years, several studies have been published on SWE of human tendons (5-17) and muscles (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), with promising results. The majority of these studies are experimental (5,6,(9)(10)(11)(12)(13)(14)(16)(17)(18)(19)(20)(21)(22)(23)(24)27,29,(31)(32)(33) with a smaller number of clinical studies (7,8,15,26,28,30,34,35).…”

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

“…The majority of these studies are experimental (5,6,(9)(10)(11)(12)(13)(14)(16)(17)(18)(19)(20)(21)(22)(23)(24)27,29,(31)(32)(33) with a smaller number of clinical studies (7,8,15,26,28,30,34,35). Additionally, several studies evaluated viscoelastic properties of the Achilles tendon (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

“…Lacourpaille and collaborators (20) used SWE to evaluate the stiffnesses of six different relaxed and contracted skeletal muscles-the tibialis anterior, vastus lateralis, biceps brachii, triceps brachii, abductor digiti minimi, and medial head of the gastrocnemius-in 14 patients with Duchenne muscular dystrophy and 13 healthy control subjects. SWE was performed using an Aixplorer US scanner.…”

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

“…Promising results have been published in the recent literature on the utility of SWE in the evaluation of several traumatic and pathologic conditions of various musculoskeletal soft tissues, including tendons (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), muscles (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), nerves (30)(31)(32), and ligaments (33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

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Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

et al. 2017

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In the past 2 decades, sonoelastography has been progressively used as a tool to help evaluate soft-tissue elasticity and add to information obtained with conventional gray-scale and Doppler ultrasonographic techniques. Recently introduced on clinical scanners, shearwave elastography (SWE) is considered to be more objective, quantitative, and reproducible than compression sonoelastography with increasing applications to the musculoskeletal system. SWE uses an acoustic radiation force pulse sequence to generate shear waves, which propagate perpendicular to the ultrasound beam, causing transient displacements. The distribution of shear-wave velocities at each pixel is directly related to the shear modulus, an absolute measure of the tissue's elastic properties. Shear-wave images are automatically coregistered with standard B-mode images to provide quantitative color elastograms with anatomic specificity. Shear waves propagate faster through stiffer contracted tissue, as well as along the long axis of tendon and muscle. SWE has a promising role in determining the severity of disease and treatment followup of various musculoskeletal tissues including tendons, muscles, nerves, and ligaments. This article describes the basic ultrasound physics of SWE and its applications in the evaluation of various traumatic and pathologic conditions of the musculoskeletal system.

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Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

et al. 2017

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“…Recently, a state-of-the-art ultrasound electrography technology called Supersonic Shear Imaging (SSI) has been used for evaluating changes in skeletal muscle shear modulus (i.e. an index of stiffness) associated with aging (Eby et al, 2015), neuromuscular (Lacourpaille et al, 2015;Lacourpaille et al, 2014), and neurological (Lee et al, 2015) conditions. Briefly, SSI uses acoustic radiation force induced by a focused ultrasound beam to generate a remote vibration within a target muscle.…”

Section: Introductionmentioning

confidence: 99%

Factors that influence muscle shear modulus during passive stretch

Koo¹,

Hug²

2015

Journal of Biomechanics

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Although elastography has been increasingly used for evaluating muscle shear modulus associated with age, sex, musculoskeletal, and neurological conditions, its physiological meaning is largely unknown. This knowledge gap may hinder data interpretation, limiting the potential of using elastography to gain insights into muscle biomechanics in health and disease. We derived a mathematical model from a widely-accepted Hill-type passive force-length relationship to gain insight about the physiological meaning of resting shear modulus of skeletal muscles under passive stretching, and validated the model by comparing against the ex-vivo animal data reported in our recent work (Koo et al. 2013). The model suggested that resting shear modulus of a slack muscle is a function of specific tension and parameters that govern the normalized passive muscle force-length relationship as well as the degree of muscle anisotropy. The model also suggested that although the slope of the linear shear modulus-passive force relationship is primarily related to muscle anatomical cross-sectional area (i.e. the smaller the muscle cross-sectional area, the more the increase in shear modulus to result in the same passive muscle force), it is also governed by the normalized passive muscle force-length relationship and the degree of muscle anisotropy. Taken together, although muscle shear modulus under passive stretching has a strong linear relationship with passive muscle force, its actual value appears to be affected by muscle's mechanical, material, and architectural properties. This should be taken into consideration when interpreting the muscle shear modulus values.

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Musculoskeletal Applications of Supersonic Shear Imaging

Gennisson

2018

Ultrasound Elastography for Biomedical Applications and Medicine

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Non‐invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy

Abstract: Supersonic shear imaging is a sensitive non-invasive technique to assess the increase in muscle stiffness associated with DMD.

Cited by 95 publications

References 19 publications

Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

Factors that influence muscle shear modulus during passive stretch

Musculoskeletal Applications of Supersonic Shear Imaging

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