Non-invasive assessment of coronary artery disease in diabetes

Veire, Nico R. Van de; Djaberi, Roxana; Schuijf, Joanne D.; Bax, Jeroen J.

doi:10.1136/hrt.2007.122788

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…However, few studies have compared the efficacy of BMI, WC, and WHR to predict the risk of subclinical atherosclerosis, represented by baPWV and CIMT values, in pre/postmenopausal women. Both baPWV and CIMT values have proven to be consistent and independent predictors for cardiovascular event in prospective studies [31]. In the present study, we showed that BMI was significantly correlated with baPWV and CIMT values only in the premenopausal women, not in the postmenopausal women.…”

Section: Discussionsupporting

confidence: 38%

Waist-to-hip ratio is better at predicting subclinical atherosclerosis than body mass index and waist circumference in postmenopausal women

et al. 2015

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Section: Discussionsupporting

confidence: 38%

Waist-to-hip ratio is better at predicting subclinical atherosclerosis than body mass index and waist circumference in postmenopausal women

et al. 2015

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“…Carotid intima-media thickness (IMT) and arterial stiffness are useful surrogate markers for subclinical atherosclerosis and are significantly correlated with various metabolic risk factors [15,16]. In prospective studies, both arterial stiffness and carotid IMT have proven to be consistent and independent predictors for cardiovascular events [17]. Recently, Dall Pozza et al [18] showed that longitudinal carotid IMT is indicative of disease progression during a four year period, even in adolescents with type 1 diabetes, and that brachial ankle pulse wave velocity (baPWV) is a non-invasive method for quickly measuring arterial stiffness that is not influenced by operator technique [19].…”

Section: Introductionmentioning

confidence: 99%

Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes

Yoo

Hwang

Hong

et al. 2011

Cardiovasc Diabetol

118

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BackgroundAdipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited.MethodsWe enrolled 60 people with type 2 diabetes, with or without carotid plaque, and 30 participants with normal glucose tolerance. We measured serum omentin-1, high-sensitivity C-reactive protein (hsCRP) levels, and the homeostasis model assessment of insulin resistance (HOMA-IR), as well as other cardiovascular risk factors. Vascular health was assessed by brachial ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT).ResultsSerum omentin-1 levels were significantly decreased in type 2 diabetes patients compared to normal glucose controls and was further reduced in type 2 diabetes patients with carotid plaque compared to those without carotid plaque. Multiple stepwise regression analysis showed that age, systolic blood pressure, history of use of statins, angiotensin receptor blockers or angiotensin-converting enzyme inhibitors, and serum omentin-1 level were independent factors determining baPWV in people with type 2 diabetes (r2 = 0.637). Furthermore, in multivariate logistic regression analysis, circulating omentin-1 level was an independent decisive factor for the presence of carotid plaque in type 2 diabetes patients, even after adjusting for age, gender, body mass index, systolic blood pressure, fasting blood glucose, low density lipoprotein cholesterol, and history of smoking and medication (odds ratio, 0.621; 95% confidence interval, 0.420-0.919; P = 0.017).ConclusionsCirculating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.

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“…Carotid intima media thickness measurement (cIMT) is another non-invasive method used to identify subclinical vascular carotid disease. cIMT reflects structural rather than functional changes in the arterial wall [17,28,29]. Normally, values increase with age; however, evidence of the acceleration of cIMT progression has been shown in the presence of metabolic disorders such as diabetes; in a meta-analysis including 24,111 patients from 24 studies, Brohall et al showed an additional mean cIMT increase of 0.13 mm in DM2 patients, suggesting a higher relative risk for cardiovascular events [30].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Indices of Vascular Function and Presence of Overt Cardiovascular Disease among Persons with Poorly Controlled Type 2 Diabetes

Antoniou

Naka

Papadakis

et al. 2021

JCDD

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The aim of this study was to assess the factors associated with impaired vascular function in patients with poorly controlled type 2 diabetes (DM2) with and without overt cardiovascular disease (CVD). Ninety-five patients with DM2 and poor glycemic control were recruited and divided into two groups: Group 1, with known CVD (n = 38), and Group 2, without CVD (n = 57). Patients in Group 2 were further subdivided into those with short (<5 years, group 2b) and long (>5 years, group 2a) diabetes duration. Subclinical markers of atherosclerosis were assessed. Glycemic control was similar in the two groups (HbA1c: 9.2% (1.5) vs. 9.4% (1.8), p = 0.44). In Group 1, lower FMD (3.13 (2.16)% vs. 4.7 (3.4)%, p < 0.05) and higher cIMT (1.09 (0.3) mm vs. 0.96 (0.2) mm, p < 0.05) was seen compared with Group 2, whereas PWV was similar (12.1 (3.4) vs. 11.3 (3.0) m/s, p = 0.10). Patients in Group 2b had significantly lower PWV and cIMT and higher FMD compared to Group 1 (p < 0.05). Among patients with poorly controlled T2D, more pronounced vascular dysfunction was present in those with overt macrovascular disease. In patients with T2D without known CVD, vascular dysfunction was associated with disease duration. The use of vascular indices for cardiovascular risk stratification in patients with T2D requires further study.

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Non-invasive assessment of coronary artery disease in diabetes

Cited by 9 publications

References 23 publications

Waist-to-hip ratio is better at predicting subclinical atherosclerosis than body mass index and waist circumference in postmenopausal women

Waist-to-hip ratio is better at predicting subclinical atherosclerosis than body mass index and waist circumference in postmenopausal women

Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes

Relationship between Indices of Vascular Function and Presence of Overt Cardiovascular Disease among Persons with Poorly Controlled Type 2 Diabetes

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