Non-invasive Assessment of Changes in Muscle Injury by Ultrasound Shear Wave Elastography: An Experimental Study in Contusion Model

Zhou, Xuelian; Wang, Chuang; Qiu, Shaodong; Mao, Lin; Chen, Fei; Chen, Shaona

doi:10.1016/j.ultrasmedbio.2018.07.016

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…One study investigated changes in shear modulus following a sustained submaximal contraction until failure of the hamstring muscles after HSI, but the athletes studied had fully recovered prior to the investigation [ 40 ]. Two studies investigated the change in elastic modulus derived from ultrasound shear wave elastography in a contusion injury in animal models [ 41 , 42 ]. In both studies, the SWS increased following injury and remained elevated throughout the study duration (21–28 days).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound shear wave speeds reduced following hamstring strain injury but not after returning to sport

Crawford,

Wille,

Joachim

et al. 2024

Insights Imaging

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Objectives The purpose of the study was to investigate differences in ultrasound shear wave speed (SWS) between uninjured and injured limbs following hamstring strain injury (HSI) at time of injury (TOI), return to sport (RTS), and 12 weeks after RTS (12wks). Methods This observational, prospective, cross-sectional design included male and female collegiate athletes who sustained an HSI. SWS imaging was performed at TOI, RTS, and 12wks with magnetic resonance imaging. SWS maps were acquired by a musculoskeletal-trained sonographer at the injury location of the injured limb and location-matched on the contralateral limb. The average SWS from three 5 mm diameter Q-boxes on each limb were used for analysis. A linear mixed effects model was performed to determine differences in SWS between limbs across the study time points. Results SWS was lower in the injured limb compared to the contralateral limb at TOI (uninjured – injured limb difference: 0.23 [0.05, 0.41] m/s, p = 0.006). No between-limb differences in SWS were observed at RTS (0.15 [-0.05, 0.36] m/s, p = 0.23) or 12wks (-0.11 [-0.41, 0.18] m/s, p = 0.84). Conclusions The SWS in the injured limb of collegiate athletes after HSI was lower compared to the uninjured limb at TOI but not at RTS or 12 weeks after RTS. Critical relevance statement Hamstring strain injury with structural disruption can be detected by lower injured limb shear wave speed compared to the uninjured limb. Lack of between-limb differences at return to sport may demonstrate changes consistent with healing. Shear wave speed may complement traditional ultrasound or MRI for monitoring muscle injury. Key points • Ultrasound shear wave speed can non-invasively measure tissue elasticity in muscle injury locations. • Injured limb time of injury shear wave speeds were lower versus uninjured limb but not thereafter. • Null return to sport shear wave speed differences may correspond to structural changes associated with healing. • Shear wave speed may provide quantitative measures for monitoring muscle elasticity during recovery. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Ultrasound shear wave speeds reduced following hamstring strain injury but not after returning to sport

Crawford,

Wille,

Joachim

et al. 2024

Insights Imaging

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“…Most studies use single impact ( Lee et al, 2019 ; Hsu et al, 2020 ). Early heavy-falling techniques used a smooth impact plane and modulated the height of the fall to injure specific muscles ( Crisco et al, 1996 ; Delos et al, 2014 ; Zhou et al, 2018 ). As a conventional SMI model, the heavy falling technique has the advantages of being noninvasive, adjustable, and easy to operate ( Deane et al, 2014 ; Zheng et al, 2019b ).…”

Section: Discussionmentioning

confidence: 99%

Research on skeletal muscle impact injury using a new rat model from a bioimpact machine

Liao

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Introduction: Skeletal muscle impact injury occurs frequently during sports, falls, and road traffic accidents. From the reported studies on skeletal muscle injury, it is difficult to determine the injury parameters. Therefore, we developed a new model of gastrocnemius impact injury in rats with a bioimpact machine, with which the experimental operation could be conducted in feasibility from the recorded parameters. Through this novel model, we study the skeletal muscle impact injury mechanisms by combining temporal and spatial variation.Methods: The gastrocnemius of anesthetized rats was injured by a small pneumatic-driven bioimpact machine; the moving speed and impact force were determined, and the whole impact process was captured by a high-speed camera. We observed the general condition of rats and measured the changes in injured calf circumference, evaluating calf injuries using MRI, gait analysis system, and pathology at different times after the injury.Results: The gastrocnemius was injured at an impact speed of 6.63 m/s ± 0.25 m/s and a peak force of 1,556.80 N ± 110.79 N. The gait analysis system showed that the footprint area of the RH limb decreased significantly on the first day and then increased. The calf circumference of the injured limb increased rapidly on the first day post-injury and then decreased in the next few days. MRI showed edema of subcutaneous and gastrocnemius on the first day, and the area of edema decreased over the following days. HE staining showed edema of cells, extensive hyperemia of blood vessels, and infiltration of inflammatory cells on the first day. Cell edema was alleviated day by day, but inflammatory cell infiltration was the most on the third day. TEM showed that the sarcoplasmic reticulum was dilated on the first day, the mitochondrial vacuolation was obvious on the second day, and the glycogen deposition was prominent on the fifth day.Conclusion: In our experiment, we developed a new and effective experimental animal model that was feasible to operate; the injured area of the gastrocnemius began to show “map-like” changes in the light microscope on the third day. Meanwhile, the gastrocnemius showed a trend of “edema-mitochondrial vacuolation-inflammatory cell aggregation” after impact injury.

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“…One is ultrasound shear wave elastography (SWE). Zhou et al 17 found that in injured muscles, the abundance of collagen fibres was correlated positively with the value of Young's modulus; thus, ultrasonic SWE could be used to quantitatively detect the pathologic process. Another study 18 reported that the ultrasonic SWE technique was a reliable method for measuring the stiffness of the vastus medialis muscle, quadriceps femoris and patellar tendon in subjects undergoing orthopaedic surgery, as well as offered the possibility of the technique being applied in monitoring stiffness before and after surgery and during rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of changes in skeletal muscle injury by computer‐aided analysis based on two‐dimensional ultrasonography combined with contrast‐enhanced ultrasonography and estimated by a modified semi‐quantitative scoring system: An experimental study in a contusion model

Zhao

Huang

et al. 2022

Int J Experimental Path

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The aim of this study was to investigate the potential application of computer‐aided analysis in the quantitative assessment of changes in skeletal muscle injury in the rabbit contusion model. Forty healthy rabbits were randomly divided into control (n = 5) and contusion (n = 35) groups. Rabbits in the contusion group were used to construct a muscle contusion model induced by a hammer hitting the right gastrocnemius, while the muscles of rabbits in the control group were non‐injured. Two‐dimensional ultrasound (2D US) and contrast‐enhanced ultrasonography (CEUS) were performed on the rabbits that had received skeletal muscle contusion injury at 1 h, and 1, 3, 7, 14, 21 and 28 days after injury. Afterwards, a multiscale blob feature (MBF) method was used to extract the textural features from the 2D US, and the muscle injuries were quantitatively evaluated. The eight textural parameters of skeletal muscle analysed by MBF at 1 h, and 1, 3 and 7 days post‐injury were found to be significantly higher in the contusion group than in the control group (p < .05). On Day 14, the textural parameters (e.g., greyscale mean [Mean], greyscale standard deviation [SDev], number of blobs, average size of blobs, homogeneity of distribution, periodicity of distribution [POD] and irregularity) were also evidently higher in the contusion group than in the control group (p < .05). On Day 28, Mean, SDev and POD in the contusion group were markedly higher (p < .05). After that, the microcirculation in the injured areas increased from Day 7 to Day 21 after injury, but decreased on Day 28 after injury. Thus the quantitative assessment of changes in skeletal muscle injury (SMI) using computer‐aided analysis allowed us to describe the geometric features of injured muscle fibres and the microperfusion changes estimated by the modified semi‐quantitative scoring system. This provides a scientific basis for the development of a novel approach for the evaluation of SMI and rehabilitation process.

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Non-invasive Assessment of Changes in Muscle Injury by Ultrasound Shear Wave Elastography: An Experimental Study in Contusion Model

Cited by 14 publications

References 29 publications

Ultrasound shear wave speeds reduced following hamstring strain injury but not after returning to sport

Ultrasound shear wave speeds reduced following hamstring strain injury but not after returning to sport

Research on skeletal muscle impact injury using a new rat model from a bioimpact machine

Quantitative assessment of changes in skeletal muscle injury by computer‐aided analysis based on two‐dimensional ultrasonography combined with contrast‐enhanced ultrasonography and estimated by a modified semi‐quantitative scoring system: An experimental study in a contusion model

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