Background: There is difference in aortic valve area (AVA) measurement between cardiac computed tomography (CCT) and transthoracic echocardiography (TTE). Objectives: To evaluate factors affecting the measurement of AVA obtained with CCT and TTE in patients with severe aortic stenosis. Method: One hundred twenty-seven consecutive patients (median age, 81 years, 57% women) that underwent TTE, CCT, and transcatheter aortic valve replacement were included. AVA was deduced from the continuity equation on TTE (AVATTE) and manual planimetry on CCT (AVACCT). Factors that related to difference between AVACCT and AVATTE were evaluated by linear regression analysis. Result: AVACCT (0.92±0.36 cm2, p<0.001) was significantly greater than AVATTE (0.69±0.16 cm2). There was a weak positive correlation between AVAs measured with CCT and TTE (r=0.25, p=0.004). There was significant difference between CCT (5.0±0.92 cm2, p<0.001) and TTE (3.52±0.77 cm2) measurements of left ventricular outflow tract (LVOT) area. The LVOT area was generally elliptical (>10% difference between LVOT diameters in 95.3% patients). Multiple linear regression