Non-invasive alternating current stimulation induces recovery from stroke

Fedorov, A.; Chibisova, Yulia; Szymaszek, Aneta; Alexandrov, Mikhail V.; Gall, Carolin; Sabel, Bernhard A.

doi:10.3233/rnn-2010-0580

Cited by 32 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No serious adverse effects have been reported in either healthy subjects or patients (Fedorov et al, 2010, Fedorov et al, 2011, Gall et al, 2010, Gall et al, 2016, Tadini et al, 2011, Abd Hamid et al, 2015, Kallel et al, 2016, Klimke et al, 2016, Nakazono et al, 2016, Naro et al, 2016b, Raco et al, 2016, Woods et al, 2016, Wu et al, 2016). The specific adverse effect would be phosphene perception.…”

Section: Introductionmentioning

confidence: 99%

Adverse events of tDCS and tACS: A review

Matsumoto

Ugawa

2017

Clinical Neurophysiology Practice

251

160

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Adverse events of tDCS and tACS: A review

Matsumoto

Ugawa

2017

Clinical Neurophysiology Practice

251

160

View full text Add to dashboard Cite

show abstract

“…Non-invasive brain stimulation methods such as transcranial alternating current stimulation (tACS) may offer a possibility to modulate neuronal oscillatory activity (for a review, see Herrmann et al, 2013 ) and human brain function in different modalities such as vision (Kanai et al, 2008 ; Laczó et al, 2012 ; Brignani et al, 2013 ; Helfrich et al, 2014a , b ; Cabral-Calderin et al, 2015 ; Vossen et al, 2015 ; Kasten et al, 2016 ; Vosskuhl et al, 2016 ), motor function (Pogosyan et al, 2009 ; Feurra et al, 2011a ; Schutter and Hortensius, 2011 ; Joundi et al, 2012 ; Brittain et al, 2013 ; Wach et al, 2013 ; Krause et al, 2014 ; Brinkman et al, 2016 ; Lustenberger et al, 2016 ; Moisa et al, 2016 ), audition (Neuling et al, 2012 ; Riecke et al, 2015 ; Heimrath et al, 2016 ; Riecke, 2016 ; Rufener et al, 2016 ), somatosensation (Feurra et al, 2011b ; Gundlach et al, 2016 ), and higher cognitive functions such as decision making, risk taking behavior, creativity, fluid intelligence, mental rotation or self-aware dreaming (Sela et al, 2012 ; Herrmann et al, 2013 ; Voss et al, 2014 ; Lustenberger et al, 2015 ; Santarnecchi et al, 2016 ; Kasten and Herrmann, 2017 ). In addition there is preliminary evidence that alternating current stimulation might be effective to support recovery of function in patients with stroke (Fedorov et al, 2010 ; Naros and Gharabaghi, 2017 ) or optic neuropathy (Sabel et al, 2011 ; Schmidt et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Somatosensory Alpha Rhythm by Transcranial Alternating Current Stimulation at Mu-Frequency

Gundlach

Müller

Nierhaus

et al. 2017

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Introduction: Transcranial alternating current stimulation (tACS) is emerging as an interventional tool to modulate different functions of the brain, potentially by interacting with intrinsic ongoing neuronal oscillations. Functionally different intrinsic alpha oscillations are found throughout the cortex. Yet it remains unclear whether tACS is capable of specifically modulating the somatosensory mu-rhythm in amplitude.Objectives: We used tACS to modulate mu-alpha oscillations in amplitude. When compared to sham stimulation we expected a modulation of mu-alpha oscillations but not visual alpha oscillations by tACS.Methods: Individual mu-alpha frequencies were determined in 25 participants. Subsequently, blocks of tACS with individual mu-alpha frequency and sham stimulation were applied over primary somatosensory cortex (SI). Electroencephalogram (EEG) was recorded before and after either stimulation or sham. Modulations of mu-alpha and, for control, visual alpha amplitudes were then compared between tACS and sham.Results: Somatosensory mu-alpha oscillations decreased in amplitude after tACS was applied at participants’ individual mu-alpha frequency. No changes in amplitude were observed for sham stimulation. Furthermore, visual alpha oscillations were not affected by tACS or sham, respectively.Conclusion: Our results demonstrate the capability of tACS to specifically modulate the targeted somatosensory mu-rhythm when the tACS frequency is tuned to the individual endogenous rhythm and applied over somatosensory areas. Our results are in contrast to previously reported amplitude increases of visual alpha oscillations induced by tACS applied over visual cortex. Our results may point to a specific interaction between our stimulation protocol and the functional architecture of the somatosensory system.

show abstract

“…More specifically, we asked whether tACS modulates blood oxygenation level dependent (BOLD) activity in a frequency-, state-, and/or taskdependent manner. We used a conventional electrode montage similar to the montages frequently used in the studies evaluating the clinical and behavioral effects of tACS [Brittain et al, 2013;Cabral-Calderin et al, 2015;Fedorov et al, 2010;Feurra et al, 2011Feurra et al, , 2013Helfrich et al, 2014a;Joundi et al, 2012;Kanai et al, 2008;Kar and Krekelberg, 2014;Laczo et al, 2012;Polania et al, 2012;Santarnecchi et al, 2013;Wach et al, 2013] with the goal of evaluating the effects of tACS designs that have proven to exert behavioral and electrophysiological effects. Three different sets of experiments are presented in which tACS was applied at 10 Hz (alpha), 16 Hz (beta), 60 Hz or 80 Hz (gamma).…”

Section: Introductionmentioning

confidence: 99%

Transcranial alternating current stimulation affects the BOLD signal in a frequency and task‐dependent manner

et al. 2015

View full text Add to dashboard Cite

Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency‐specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto‐parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. Hum Brain Mapp 37:94–121, 2016. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc

show abstract

Non-invasive alternating current stimulation induces recovery from stroke

Cited by 32 publications

References 45 publications

Adverse events of tDCS and tACS: A review

Adverse events of tDCS and tACS: A review

Modulation of Somatosensory Alpha Rhythm by Transcranial Alternating Current Stimulation at Mu-Frequency

Transcranial alternating current stimulation affects the BOLD signal in a frequency and task‐dependent manner

Contact Info

Product

Resources

About