Non-inherited maternal HLA antigens and protection against serisitisation

Pohanka, E; Cohen, Nadine; Bw, Colombe; C, Lou; Salvatierra, Oscar; Mr, Garovoy

doi:10.1016/0140-6736(90)92488-4

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…However, many of these patients do not form antibodies to NIMH [47]. Subsequent repetitive antigen challenge may break this tolerance [48]. Tolerance to NIMH may in part be mediated by antiidiotypic antibodies [49].…”

Section: Discussionmentioning

confidence: 99%

Inheritance of MHC class II genes in IDDM studied in population-based affected and control families

et al. 1994

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SummaryThe transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p < 0.025) and DQBI*0302 (p < 0.01) from both parents to the index patient. There was an increased transmission of DQBI*0302 (p < 0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p < 0.01) of positively associated haplotypes (DR4-DQAI* 0301-DQBl*0302, DR3-DQAI*0501-DQBI*0201) compared to all parental haplotypes in the control families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes differed from those expected in the control families. In conclusion, the observed reduction of IDDM-positively associated haplotypes in patient non-inherited maternal haplotypes, but not in non-inherited paternal haplotypes, suggests that tolerance during fetal life to maternal non-inherited HLA molecules may be important to diabetes development. [Diabetologia (1994[Diabetologia ( ) 37: 1105[Diabetologia ( -1112

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Section: Discussionmentioning

confidence: 99%

Inheritance of MHC class II genes in IDDM studied in population-based affected and control families

et al. 1994

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“…18 However, the true existence of such tolerogenic "NIMA effect" has still been the subject of debate due to lack of the knowledge of the underlying immunologic mechanisms. 19,20 Recently, Andrassy et al have shown in a murine experimental model that more than half of the H-2 b/b offspring that had experienced both oral and in utero exposure to noninherited H-2 d antigens of semiallogenic H-2 b/d mothers could accept fully allogeneic H-2 d/d vascularized heart allografts for a long time. 21 Importantly, they also demonstrated that the tolerant mice had higher levels of maternal cell microchimerism after their birth as compared with the nontolerant mice, suggesting the role of long-term maternal microchimerism for the induction and maintenance of NIMA-specific allotolerance.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism

Ichinohe

Uchiyama

Shimazaki

et al. 2004

Blood

132

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“…12 However, in a study of 140 patients with ESRD who were given donor-specific transfusions from donors who were mismatched for NIMA or NIPA, development of donor-specific anti-HLA antibody, rejection risk, and graft survival after kidney transplantation were similar between the 2 groups. 16 In contrast, retrospective analysis of 5000 paternal kidney transplant recipients using Collaborative Transplant Study data showed that paternal grafts had a superior 3-year graft survival compared with maternal grafts, a finding that has been corroborated by 1 other single-center study. 13,17 Our study has shown that maternal donor kidneys were associated with at least a 50% increased risk of acute rejection and multiple rejections, with the majority occurring within the first 6 months after transplantation.…”

Section: Discussionmentioning

confidence: 91%

Maternal compared with paternal donor kidneys are associated with poorer graft outcomes after kidney transplantation

Lim

McDonald

Coates

et al. 2016

Kidney International

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Noninherited maternal human leukocyte antigens may be less detrimental on allograft outcomes after kidney transplantation compared with noninherited paternal antigens, but this association in the era of modern immunosuppression remains unknown. Here we determine the association between parental donor kidneys, acute rejection, and graft failure in primary live-donor parental kidney transplant recipients using data from the Australia and New Zealand Dialysis and Transplant Registry between 1997 and 2012. Of the 1139 recipients followed for a median of 7.2 years (8588 person-years), 652 received kidneys from maternal donors. Compared with paternal donor kidneys, maternal donor kidneys were associated with a significantly increased risk of acute rejection (adjusted odds ratio 1.54; 95% confidence interval [CI], 1.14-2.07) and significant overall graft loss. The latter was confined to recipients who have experienced acute rejection (adjusted hazard ratio 1.60; 95%CI, 1.05-2.43) but not in those who did not experience acute rejection. Thus, our study suggests that recipients of maternal donor kidneys have a greater risk of rejection and graft loss. Hence, clinicians and patients should be cognizant of this association when determining which of the 2 parental donors is most suitable for transplantation.

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Non-inherited maternal HLA antigens and protection against serisitisation

Cited by 12 publications

References 16 publications

Inheritance of MHC class II genes in IDDM studied in population-based affected and control families

Inheritance of MHC class II genes in IDDM studied in population-based affected and control families

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism

Maternal compared with paternal donor kidneys are associated with poorer graft outcomes after kidney transplantation

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