Non‐Inflammatory Disorders of Subcutaneous Fat

Abstract

This chapter addresses principally non‐inflammatory acquired disorders of subcutaneous fat with an emphasis on acquired lipodystrophy, fat hypertrophy, subcutaneous lipomatosis and lipoedema. Acquired lipodystrophy may be associated with other medical conditions and may occur as a result of antiretroviral therapy, total body irradiation or haematopoietic stem cell transplant, or injection of medications. Some of the subcutaneous lipodermatoses may have a genetic component. Also included in the discussion are conditions such as cellulite and skin conditions related to obesity. For each of these acquired disorders, relevant pathophysiology, methods of diagnosis and management options are discussed.