Non-immune hydrops: Qatar experience

Hasnani-Samnani, Zohra; Mahmoud, Mohamed I.; Farid, Ibrahim; Naggar, Eman Al; Ahmed, Badreldeen

doi:10.3109/14767058.2012.733781

Cited by 11 publications

(14 citation statements)

References 28 publications

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“…After evaluating these articles and their references, 22 studies were identified that met our inclusion criteria. 3,4,7,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Figure 1 shows the PRISMA flow diagram.…”

Section: Resultsmentioning

confidence: 99%

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Lysosomal storage disorders as an etiology of nonimmune hydrops fetalis: A systematic review

et al. 2021

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We performed a systematic review of the literature to evaluate the incidence and types of lysosomal storage disorders (LSD) in case series of nonimmune hydrops fetalis (NIHF). PubMed, Ovid, and clinicaltrials.gov were reviewed for case series evaluating the workup of NIHF diagnosed in utero or in the neonatal period in human subjects from 1979 to August 2020. Retrospective case series with at least five cases of fetal and/or neonatal NIHF with its workup mentioned were identified. Idiopathic NIHF was defined as NIHF without an apparent cause after initial standard-of-care workup. In total, 22 case series with 2678 total cases of NIHF were identified. The overall incidence of LSD was 6.6% (177/2663) in NIHF cases that were tested for any LSD, and 8.2% (177/2151) in idiopathic NIHF cases. The most common LSD identified in cases of NIHF were mucopolysaccharidosis type VII, galactosialidosis, infantile sialic acid storage disease, Gaucher disease, GM1 gangliosidosis, and sialidosis. More than 40% of the most common LSD causes of NIHF have a potential postnatal treatment. LSD testing for NIHF allows for early diagnosis, better counseling and appropriate management, planning for possible early treatment, and counseling for recurrence risk.

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Section: Resultsmentioning

confidence: 99%

“…The methodology for diagnosis of NIHF was not specified in six studies (27.3%). 3,4,13,16,25,28 Most studies (59.1%) did not provide the exact list of LSD tested for (Table 1). Among the studies where specific LSD testing was not disclosed, it was not evident if every case underwent LSD testing.…”

Section: Resultsmentioning

confidence: 99%

Lysosomal storage disorders as an etiology of nonimmune hydrops fetalis: A systematic review

et al. 2021

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“…Fetal CH is characterized by edema and single or multiple fluidfilled collections located at sites of lymphatic-venous connection, usually in the posterior neck and back of a fetus [20]. NIH is defined as excessive fluid accumulation in two or more extravascular compartments such as the pleural and pericardial spaces, peritoneal cavity, skin, and placenta, without any identifiable circulating antibody to red blood cell antigens [21,22].…”

Section: Methodsmentioning

confidence: 99%

Prenatal karyotype results of fetuses with nuchal edema, cystic hygroma, and non-immune hydrops

Gezer¹,

Ekin²,

Gezer³

et al. 2015

Clin. Exp. Obstet. Gynecol.

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Purpose: Subcutaneous edema detected sonographically in the forms of nuchal edema, cystic hygroma (CH), or non-immune hydrops (NIH) may be a sign of chromosomal abnormalities. The aim of this study was to investigate the chromosome abnormality incidence in fetuses with nuchal edema, CH, or NIH. Materials and Methods: The authors performed cytogenetic analysis of 218 singleton fetuses with ultrasound diagnosis of subcutaneous edema in the forms of nuchal edema in the first and second trimesters. Results: Chromosomal abnormality rates were 30.4, 10.4, 36.8, 34.1, and 60% in the nuchal translucency (NT), nuchal fold thickness (NF), CH, NIH, and CH with NIH groups, respectively. In 71 cases with detected chromosomal abnormalities, 37%, 44%, 15%, and 4% of the pathologic karyotypes were identified as monosomy X, trisomy 21, trisomy 18, and trisomy 13, respectively. Conclusions: This study confirms that subcutaneous edema detected sonographically, in the forms of nuchal edema, CH, or NIH, is a significant indicator of abnormal karyotype and deserves further investigation.

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“…Hydrops fetalis is defined as a condition of excessive fluid accumulation in the extravascular com partment of the fetus leading to extensive subcutaneous tissue edema and the collection of fluid in the fetal serous cavities [1]. These cavities can be the pleural, pericardial and peritoneal cavi ties, or thickened placenta [2]. More recently, the definition of hy drops fetalis was modified to the accumulation of abnormal fluid in at least 2 different fetal compartments [3].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Etiologies of Hydrops Fetalis

Yuan

2017

Z Geburtshilfe Neonatol

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Cardiac etiologies of hydrops fetalis have been a topic of concern due to challenging perinatal management. The common cardiac etiologies leading to hydrops fetalis include structural cardiac anomalies, cardiac dysrhythmias, cardiac tumors, cardiomyopathy and myocarditis. The mechanisms of cardiogenic hydrops fetalis may be: 1) elevation of atrial pressure and volume overload, 2) decrease of cardiac output, and 3) development of congestive heart failure. The diagnosis of hydrops fetalis was usually made at 19-36 gestational weeks, when ultrasound is a highly effective diagnostic method. Intrauterine interventions for certain congenital heart defects, maternal transplacental or direct fetal medications and fetal pacing placement for cardiac arrhythmias, and fetal or postnatal tumor resections are important progressions of etiologic treatment for hydrops fetalis. Treatment strategies for hydrops fetalis are usually ultrasound-guided pericardiocentesis and feto-amniotic shunting, whereas reaccumulation may require further interventions or postnatally. Hydrops fetalis often carries a poor prognosis, and mortality remains high. Current developments in the management of hydrops fetalis should encourage physicians to attempt further fetal interventions.

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Non-immune hydrops: Qatar experience

Abstract: Non-immune hydrops fetalis is a complex problem. Establishment of a clear procedure for the follow up of such patients is extremely important.

Cited by 11 publications

References 28 publications

Lysosomal storage disorders as an etiology of nonimmune hydrops fetalis: A systematic review

Lysosomal storage disorders as an etiology of nonimmune hydrops fetalis: A systematic review

Prenatal karyotype results of fetuses with nuchal edema, cystic hygroma, and non-immune hydrops

Cardiac Etiologies of Hydrops Fetalis

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