Non-IBD and noninfectious colitis

Nielsen, Ole Haagen; Vainer, Ben; Rask-Madsen, J

doi:10.1038/ncpgasthep1005

Cited by 65 publications

(7 citation statements)

References 98 publications

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“…While radiotherapy (RT), as one of the most desirable and effective local cancer treatments, inhibits tumor growth and progression, 1 , 2 post‐radiation side effects, particularly at the treatment site, significantly impact patients’ lifestyles. 3 , 4 , 5 , 6 Even advanced guided RT methods, such as intensity‐modulated radiotherapy (IMRT) 7 , 8 and volumetric‐modulated radiotherapy (VMAT), 9 , 10 induce considerable side effects. For example, post‐radiation colitis 11 and cardiac ischemia 12 have been reported following IMRT and VMAT in prostate and breast cancers, respectively.…”

Section: Introductionmentioning

confidence: 99%

Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges

et al. 2021

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“…The colorectal specimens consisted of 78 UC, 22 CD, 20 infectious colitis (such as bacterial dysentery, pseudomembranous enteritis and viral enteritis), 26 non-IBD and noninfectious colitis(such as microscopic colitis, diversion colitis, diverticular colitis, eosinophilic colitis, ischemic colitis and radiation colitis) [18], 16 sporadic adenomas (SAs) (6 UC-associated and 10 non-UC-associated), 4 dysplasia-associated lesion or mass (DALM), 10 sporadic CRC, 4 UC-related CRC, 10 hyperplastic polyps, and 60 normal tissues obtained from people free of intestinal diseases. The diagnosis of IBD was based on clinical, endoscopic, and pathohistological criteria as described by Lennard-Jones [19].…”

Section: Methodsmentioning

confidence: 99%

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Zhao

et al. 2016

Med Sci Monit

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BackgroundActivated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity.Material/MethodsA total of 250 individuals who underwent total colonoscopy were collected randomly from January 2007 to May 2013 in Nanfang Hospital, Guangzhou, China. Colorectal mucosal biopsy specimens were obtained by endoscopy from 78 patients with ulcerative colitis (UC), 22 with Crohn’s disease (CD), 20 with infectious colitis, 26 with non-IBD and noninfectious colitis, 16 with sporadic adenomas, 4 with dysplasia-associated lesions or masses, 10 with sporadic colorectal cancer (CRC), 4 with UC-related CRC, 10 with hyperplastic polyps, and 60 without colonic abnormalities. ACK1 protein levels were determined immunohistochemically. The correlations of ACK1 expression with disease activity and severity were also evaluated.ResultsSignificantly increased ACK1 expression was observed in epithelial cells of colorectal mucosa with inflammation and dysplasia compared to controls (P<0.05). ACK1 expression correlated with clinical activity in IBD (χ2=4.57, P=0.033 for UC; χ2=5.68, P=0.017 for CD), as well as grade of dysplasia in preneoplastic lesions (P<0.05). No significant differences in ACK1 expression were found between UC and CD, or between IBD and non-IBD conditions (P>0.05).ConclusionsACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

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“…Data on cohorts of patients with non-specific ulcers or erosions of the colon are aged and scarce. [36][37][38] Eosinophilic colitis, related to allergies, similarly, are more frequent in a pediatric setting. Moreover, an association between positivity to allergic tests and symptoms is not well established in adults.…”

Section: Other Causes Of Nicmentioning

confidence: 99%

Endoscopic features of non-IBD colitis

Pigò,

Reggiani Bonetti Luca,

Conigliaro Rita

2023

Asian J Med Sci

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Background: Studies about the endoscopic aspect of non-inflammatory bowel disease (IBD) colitis are scarce. Aims and Objectives: The aim of this retrospective study was to describe the endoscopic appearance of non-IBD colitis (NIC) in an outpatient cohort. Materials and Methods: All cases of NIC, from 2018 to 2021, with a recent outpatient colonoscopy, were enrolled. Diagnosis was based on clinical, endoscopic, and histological characteristics, and follow-up ≥6 months to recognize misdiagnosed IBD because of mimic causes. Results: 158 patients (63 males, age 54 years±19) performed a colonoscopy with a final diagnosis of NIC associated with drug-exposition (74), food allergies (26), recent/active gastrointestinal infections (20), ischemic colitis (14), segmental colitis associated diverticulosis (SCAD) (10), obstructed defecation syndrome (ODS) (8) and microscopic colitis (6). Frequencies of endoscopic features and colon distribution were: Drug exposition (hyperemia, erosions/ulcers, 88%; right colon, 70%), recent infection (erosions, 60%; left colon/rectum, 88%), food allergies (red spots/erosions, 67%; all the colon), ischemic colitis (ulcers, 86%; right or left colon), SCAD (hyperemia/edema, 75%; always left colon), ODS (hyperemia, erosions, and loss of vascularity, 90%; always rectum), microscopic colitis (edema and hyperemia; all the colon). Conclusion: Drug-exposition is the most frequent cause of out-patient NIC. In an appropriate diagnostic context, red spots, hyperemia, and erosions are associated with drug expositions, recent infections, and food allergies. Ulcers are more frequent with ischemic colitis or drug-exposition.

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Non-IBD and noninfectious colitis

Cited by 65 publications

References 98 publications

Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges

Positive electrostatic therapy of metastatic tumors: selective induction of apoptosis in cancer cells by pure charges

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Endoscopic features of non-IBD colitis

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