Non<i>‐Helicobacter pylori</i> Related Duodenal Ulcer Disease in Children

Elitsur, Yoram; Lawrence, Zandra

doi:10.1046/j.1523-5378.2001.00034.x

Cited by 52 publications

(51 citation statements)

References 41 publications

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“…18 nevertheless, a much lower frequency (around 2%) of ulcers was reported in some other countries. 12,14,16 the male predominance, found in some studies, may be due to endocrinologic factors. 23,24 the apparent different prevalence of gastro-duodenal lesions between these different studies may be biased by the fact that the lifestyles are not comparable, unequal availability of endoscopy facilities, referral policy to third level hospitals with endoscopy facilities, total number of endoscopy per year, proportion of older children in each center (lesions more frequent in older ones), PPi's prescription policy without endoscopy or H. pylori frequency in the local population.…”

Section: Discussionmentioning

confidence: 95%

Helicobacter pylori Infection in European Children with Gastro-duodenal Ulcers and Erosions

Bontems

Kalach

Vanderpas

et al. 2013

Pediatric Infectious Disease Journal

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Background: to analyze risk factors associated with gastro-duodenal ulcers and erosions in children. Methods: Open, prospective, multicenter, case-control study carried out in 11 european countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. logistic regression models were performed with adjustment for centers and age groups. Results: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P < 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). exposure factors for duodenal ulcers were H. pylori infection (P < 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). no risk factor was identified in 97/202 (48.0%) cases. Conclusions: H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. no risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.

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Section: Discussionmentioning

confidence: 95%

Helicobacter pylori Infection in European Children with Gastro-duodenal Ulcers and Erosions

Bontems

Kalach

Vanderpas

et al. 2013

Pediatric Infectious Disease Journal

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“…This figure is surprising, since we recently reported a series of duodenal ulcer cases with 95.3% of the patients with H pylori (5) . However, other ulcer cases have to be taken into account, such as use of anti-inflammatory drugs and non-H pylori related ulcer disease (3) . Change in the profile of patients who attend the service may be reflected in the found result.…”

Section: Discussionmentioning

confidence: 99%

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Kawakami

Machado

Ogata

et al. 2008

Arq. Gastroenterol.

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-Background -Decreasing prevalence of H pylori infection has been reported in some countries. Aim -To evaluate the prevalence of Helicobacter pylori infection in a 10-year period in children submitted to upper digestive endoscopy. Methods -It was a retrospective observational study. The records of 1,165 endoscopies performed during a 10-year period in a public hospital of the City of São Paulo, SP, Brazil, in patients up to 18-year-old. Only the first endoscopy was considered. Helicobacter pylori infection was defined by the rapid urease test, performed with one fragment of antral mucosa. Chi-square for trend has been estimated to compare Helicobacter pylori prevalence across the period. Results -The main indication for endoscopy was epigastric pain (47.4%). There were 392 patients with H pylori infection (33.6%), 12.8% being infants, 19.4% toddlers, 28.8% schoolchildren and 46.3% adolescents. Prevalence was 60.47% in the first year of the study and 30.43% in the last. Among the less than 6-year-old patients there was a decrease in infection prevalence from 25% for the 1993-6 period to 14.3% in the 2000-02 period, while among the over 12-year-old patients the decrease was from 55.5% in the first period to 39.6% in the latter. The decrease in H pylori infection prevalence was more intense within patients with epigastric pain, in which prevalence has decreased from 48.2% (92/191) in 1993-6, to 41.9% (65/155) in 1997-9 and 27.7% (57/206) in 2000-02. Conclusion -The study suggests a significant decrease in the prevalence of H pylori infection regarding the studied patients. The trend was mainly observed in the younger age group and in patients with epigastric pain.

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“…Peptic ulcer usually develops in children secondary to a major stressful condition or use of NSAIDs or corticosteroids [39]. The limited knowledge on this issue implies that peptic ulcers are not rare even during childhood and that the frequency shows a wide variation in different geographical areas, ranging from 5-35% [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic and Histopathologic Findings Associated with H. pylori Infection in Very Young Children

et al. 2008

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Most of the individuals infected with H. pylori acquire the infection early in life. However, there is limited data regarding endoscopic and histopathologic findings of H. pylori infection when it is acquired during infancy. The aim of this study was to investigate the H. pylori-related endoscopic and histopathological findings in children younger than 2 years of age. One hundred and fifty-two infants who underwent upper gastrointestinal endoscopy were included in the study. The diagnosis of H. pylori infection was based on histopathology and a positive rapid urease test. Forty of 152 (26.3%) infants were infected with H. pylori, and 65% of the infected infants had histopathologic gastritis. There were no clinical or endoscopic findings suggestive of H. pylori infection. No correlation could be found between the density of H. pylori and the severity of gastritis. H. pylori infection is associated with various degrees of gastritis in more than half of the infected infants. Since the likelihood of normal histopathology is rare in H. pylori-infected infants, its long-term complications should be cautiously followed up in endemic areas.

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Non‐Helicobacter pylori Related Duodenal Ulcer Disease in Children

Cited by 52 publications

References 41 publications

Helicobacter pylori Infection in European Children with Gastro-duodenal Ulcers and Erosions

Helicobacter pylori Infection in European Children with Gastro-duodenal Ulcers and Erosions

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Endoscopic and Histopathologic Findings Associated with H. pylori Infection in Very Young Children

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