NON <i>CAMPYLOBACTER PYLORI</i> SPIRAL ORGANISMS IN THE GASTRIC ANTRUM

Lee, A.; Eckstein, Robert P.; Fevre, D. I.; Dick, Elizabeth; Kellow, John

doi:10.1111/j.1445-5994.1989.tb00232.x

Cited by 30 publications

(10 citation statements)

References 6 publications

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“…In vitro cultivation of this large gastric spiral bacterium remains elusive, but inoculation of mice and rats with gastric homogenates from infected humans and nonhuman primates permitted cultures to be maintained in vivo (77,243). Mouse gastric tissue infected with organisms from two human patients was then used as a DNA template to amplify and sequence bacterial 16S rRNA genes, a technology that is now commonplace for the identification of uncultivated bacteria (347).…”

Section: "Helicobacter Heilmannii"mentioning

confidence: 99%

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

2001

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Since Helicobacter pylori was first cultivated from human gastric biopsy specimens in 1982, it has become apparent that many related species can often be found colonizing the mucosal surfaces of humans and other animals. These other Helicobacter species can be broadly grouped according to whether they colonize the gastric or enterohepatic niche. Gastric Helicobacter species are widely distributed in mammalian hosts and are often nearly universally prevalent. In many cases they cause an inflammatory response resembling that seen with H. pylori in humans. Although usually not pathogenic in their natural host, these organisms serve as models of human disease. Enterohepatic Helicobacter species are an equally diverse group of organisms that have been identified in the intestinal tract and the liver of humans, other mammals, and birds. In many cases they have been linked with inflammation or malignant transformation in immunocompetent hosts and with more severe clinical disease in immunocompromised humans and animals. The purpose of this review is to describe these other Helicobacter species, characterize their role in the pathogenesis of gastrointestinal and enterohepatic disease, and discuss their implications for our understanding of H. pylori infection in humans

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Section: "Helicobacter Heilmannii"mentioning

confidence: 99%

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

2001

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“…Mucus scrapings from animals and human patients showing the presence of gastrospirilla were homogenized and inoculated into specific-pathogen-free mice, as described elsewhere Lee et al, 1989).…”

Section: Methodsmentioning

confidence: 99%

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

O’Rourke

Solnick

Neilan

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

127

166

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While Helicobacter pylori is accepted as the major bacterial agent of gastric disease in humans, some patients and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as ‘Helicobacter heilmannii’ or ‘Gastrospirillum hominis’. Taxonomic classification of these bacteria has been hampered by the inability to cultivate them in vitro and by the inadequate discriminatory power of 16S rRNA gene sequence analysis. This study describes the detection and phylogenetic analysis of 26 different gastrospirillum isolates from humans and animals, which incorporates sequence data based on the 16S rRNA and urease genes. Fifteen gastrospirilla detected in humans, primates and pigs clustered with ‘Candidatus Helicobacter suis’, thus expanding the host range for this organism. By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis, Helicobacter bizzozeronii and Helicobacter salomonis. However, urease gene sequence analysis allowed for the discrimination of this latter group into four discrete clusters, three of which contained the above recognized species. The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name ‘Candidatus Helicobacter heilmannii’ is proposed.

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“…We were the first to isolate a helicobacter from cats (Helicobacter felis), an organism subsequently used in animal models of gastric infection [6][7][8]. We have also maintained a collection of 'H heilmannii '-like isolates from humans and a number of different animal species [9][10][11]. These bacteria have been shown to be capable of inducing active chronic gastritis in various mouse strains [6,7,12].…”

Section: Introductionmentioning

confidence: 99%

Gastric B‐cell mucosa‐associated lymphoid tissue (MALT) lymphoma in an animal model of ‘Helicobacter heilmannii’ infection

O'Rourke

Dixon

Jack

et al. 2004

The Journal of Pathology

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While Helicobacter pylori is accepted as the dominant human gastric bacterial pathogen, a small percentage of human infections have been associated with another organism, commonly referred to as 'Helicobacter heilmannii', which is more prevalent in a range of animal species. This latter bacterium has been seen in association with the full spectrum of human gastric diseases including gastritis, peptic ulceration, and gastric carcinomas, including gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study describes an analysis of the pathogenic potential of a number of 'H heilmannii' isolates in an animal model of gastric MALT lymphoma. BALB/c mice were infected with ten different 'H heilmannii' isolates originating from both human and animal hosts. The animals were examined at various time points for up to 28 months after infection. The infected animals initially developed a chronic inflammatory response within 6 months. This histological response increased in severity with the length of infection, with the development of overt lymphoma in some animals 18 months after infection. MALT lymphomas were detected in up to 25% of the infected animals. The prevalence of lymphoma was dependent on the length of infection and the origin of the infecting isolates. A range of other histological features accompanied the lymphocytic infiltration, including invaginations of the gastric epithelium and associated hyperplastic tissue, mucus metaplasia, and a small number of diffuse large B-cell lymphomas. The ability to manipulate experientially the presence of the bacterium in the animal model will allow further studies examining the role of antigen drive in the development of Helicobacter-associated MALT lymphoma.

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NON CAMPYLOBACTER PYLORI SPIRAL ORGANISMS IN THE GASTRIC ANTRUM

Cited by 30 publications

References 6 publications

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

Gastric B‐cell mucosa‐associated lymphoid tissue (MALT) lymphoma in an animal model of ‘Helicobacter heilmannii’ infection

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