Clinical practice, HIV-infected patients can be hospitalized for many problems. Especially in patients with late clinical presentation, differential diagnoses are often relatively broad. Besides the clinical symptoms and abnormal laboratory results, skin lesions are common problems in these patients. Cutaneous lesions (if they exist) range from typical to atypical and are crucial and valuable clues for diagnosis. In this article, we review the manifestations and importance of cutaneous lesions that present in HIV-infected patients with opportunistic infections.