Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review

Cheema, Deepti; Coomarasamy, Arri; El-Toukhy, Tarek

doi:10.1007/s00404-007-0390-9

Cited by 88 publications

(49 citation statements)

References 65 publications

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“…It has been suggested that central NE/5-HT equilibrium can have a stimulatory or inhibitory effect on the eccrine sweat glands, depending on the resulting NE tone [11] . Consistent with this hypothesis, drugs with significant NE and 5-HT reuptake inhibition -like paroxetine, venlafaxine and tricyclic antidepressants -show improvement in postmenopausal hot flushes and sweating, but not others like fluoxetine with no significant NE reuptake properties [12,13] . Also, mirtazapine with both NE and 5-HT action has been found useful in hyperhidrosis [14] .…”

Section: Discussionmentioning

confidence: 55%

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

Katshu

Bhattacharya²,

Nizamie³

2011

Dermatology

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Primary palmoplantar hyperhidrosis (PPH) is believed to be a dysfunction of emotional sweating, with an estimated prevalence of around 3%. Several treatment options including topical antiperspirants, tap water iontophoresis, botulinum toxin injections, oral anticholinergics, and tricyclic antidepressants are available, each with a significant adverse event profile. For the first time, we report a PPH patient with comorbid juvenile myoclonic epilepsy (JME) treated successfully with a combination of paroxetine and divalproex sodium. Paroxetine resulted in improvement in PPH, possibly through its anticholinergic and/or noradrenergic actions. Though the occurrence of PPH and JME together seems to be a chance association, some common frontal lobe mechanisms may be involved that need to be explored further.

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Section: Discussionmentioning

confidence: 55%

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

Katshu

Bhattacharya²,

Nizamie³

2011

Dermatology

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“…a 4 b 2 g 2S ). Due to the positive GABA A allosteric modulatory effects of Ac-SM (and potentially other cycloartane glycosides; Cicek et al, 2010), it is tempting to speculate that this GABA A receptor modulation leading to sedation and muscle relaxation contributes to the alleviation of mild to moderate symptoms in menopause reported in clinical studies with preparations from A. racemosa L., especially when hot flushes are associated with sleep and mood disturbances Frei-Kleiner et al, 2005;Osmers et al, 2005;Verhoeven et al, 2005;Newton et al, 2006;Pockaj et al, 2006;Uebelhack et al, 2006;Cheema et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABA_A Receptors and Induces Pronounced Sedation in Mice

Strommer¹,

Khom²,

Kastenberger³

et al. 2014

J Pharmacol Exp Ther

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23-O-Acetylshengmanol 3-O-b-D-xylopyranoside (Ac-SM) isolated from Actaea racemosa L.-an herbal remedy for the treatment of mild menopausal disorders-has been recently identified as a novel efficacious modulator of GABA A receptors composed of a 1 -, b 2 -, and g 2S -subunits. In the present study, we analyzed a potential subunit-selective modulation of GABAinduced chloride currents (I GABA ) at GABA concentrations eliciting 3-8% of the maximal GABA response (EC 3-8 ) through nine GABA A receptor isoforms expressed in Xenopus laevis oocytes by Ac-SM with two-microelectrode voltage clamp and behavioral effects 30 minutes after intraperitoneal application in a mouse model. Efficacy of I GABA enhancement by Ac-SM displayed a mild a-subunit dependence with a 2 b 2 g 2S (maximal I GABA potentiation [E max ] 5 1454 6 97%) and a 5 b 2 g 2S (E max 5 1408 6 87%) receptors being most efficaciously modulated, followed by slightly weaker I GABA enhancement through a 1 b 2 g 2S (E max 5 1187 6 166%) , a 3 b 2 g 2S (E max 5 1174 6 218%), and a 6 b 2 g 2S (E max 5 1171 6 274%) receptors and less pronounced effects on receptors composed of a 4 b 2 g 2S (E max 5 752 6 53%) subunits, whereas potency was not affected by the subunit composition (EC 50 values ranging from a 1 b 2 g 2S 5 35.4 6 12.3 mM to a 5 b 2 g 2S 5 50.9 6 11.8 mM). Replacing b 2 -with b 1 -or b 3 -subunits as well as omitting the g 2S -subunit affected neither efficacy nor potency of I GABA enhancement by Ac-SM. Ac-SM shifted the GABA concentration-response curve toward higher GABA sensitivity (about 3-fold) and significantly increased the maximal GABA response by 44 6 13%, indicating a pharmacological profile distinct from a pure allosteric GABA A receptor modulator. In mice, Ac-SM significantly reduced anxiety-related behavior in the elevated plus maze test at a dose of 0.6 mg/kg, total ambulation in the open field test at doses $6 mg/kg, stressinduced hyperthermia at doses $0.6 mg/kg, and significantly elevated seizure threshold at doses $20 mg/kg body weight. High efficacy and long biologic half-life of Ac-SM suggest that potential cumulative sedative side effects upon repetitive intake of A. racemosa L. preparations might not be negligible.

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“…Skuteczność akupunktury w leczeniu uderzeń gorąca określa się na ok. 50%, więc nie jest to leczenie tak skuteczne jak MHT, ale dużą zaletą tej metody jest to, że można ją stosować również u pacjentek z nowotworem piersi [50,[57][58][59]. Obecnie w wielu ośrodkach, szczególnie tam, gdzie znalazły zastosowanie zasady medycyny integracyjnej, akupunktura jest stosowana jako jedna z metod terapii, w tym leczenia uderzeń gorąca [60][61][62][63][64][65][66].…”

Section: Wstępunclassified

Is acupuncture effective in treatment of hot flashes?

Woźniak¹,

Ziółkowski²,

Stetkiewicz³

et al. 2012

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StreszczenieMenopauza jest kolejnym etapem życia kobiety, w którym bardzo często dochodzi do obniżenia jakości życia ze względu na występowanie wielu schorzeń i objawów, m.in. objawów wypadowych typu uderzenia gorąca. Uderzenia gorąca i nadmierne pocenie się, będące ich nocnym odpowiednikiem, występują w okresie okołome-nopauzalnym u większości kobiet. Jednocześnie są najczęstszym powodem zgłaszania się pacjentek w okresie okołomenopauzalnym do ginekologa. Podstawowym sposobem terapii tych zaburzeń jest stosowanie menopauzalnej terapii hormonalnej (menopausal hormone therapy -MHT).Jednak nie wszystkie kobiety mogą stosować MHT, a część z nich dodatkowo obawia się terapii hormonalnej. Ta grupa pacjentek szuka alternatywnego sposobu złagodzenia objawów klimakterycznych. Jedną z tych metod jest akupunktura, która w ostatnim dziesięcioleciu znalazła uznanie jako metoda bezpieczna i skuteczna. Autorzy przeprowadzili retrospektywne badanie grupy 86 pacjentek w okresie okołomenopauzalnym, niestosujących MHT, z nasilonymi objawami naczynioruchowymi, które poddały się w latach 2010-2011 zabiegom akupunktury. Badanie to miało odpowiedzieć na pytanie o skuteczność akupunktury w leczeniu uderzeń gorąca.Słowa kluczowe: akupunktura, menopauza, uderzenia gorąca. SummaryThe menopause is a successive stage of the woman's life, during which the quality of her life decreases very frequently due to the occurrence of many diseases and symptoms, among others, the perimenopausal symptoms such as hot flashes. Hot flashes and hidrosis as their night equivalent, appear during the perimenopausal period in the majority of women. At the same time, they are the most frequent reason of women patients in the perimenopausal period, for seeing the gynaecologist. The basic therapeutic method used in treatment of the above mentioned disorders is the menopausal hormone therapy (MHT).Nevertheless, not every woman can apply the MHT, and some women are also afraid of using any hormone therapy. Namely, this group of women is looking for an alternative way to relieve symptoms of the climacteric. One of these methods is acupuncture, which gained a recognition within the last decade as a safe and effective method. The authors conducted a retrospective study with a group of 86 women patients in the perimenopausal period with the exacerbated vasomotor symptoms, who were not applying any MHT, but who underwent acupuncture treatment in 2010-2011. The study was to answer a question about effectiveness of acupuncture in treatment of hot flashes.

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Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review

Cited by 88 publications

References 65 publications

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABA_A Receptors and Induces Pronounced Sedation in Mice

Is acupuncture effective in treatment of hot flashes?

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Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review

Cited by 88 publications

References 65 publications

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

Efficacy of Paroxetine in Primary Palmoplantar Hyperhidrosis Occurring with Juvenile Myoclonic Epilepsy

A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABAA Receptors and Induces Pronounced Sedation in Mice

Is acupuncture effective in treatment of hot flashes?

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A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABA_A Receptors and Induces Pronounced Sedation in Mice