Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Che, Xiaohang; Chen, Yi‐Chen; Chen, Chunlin; Ye, Xiao-lei; Zhu, Hong

doi:10.1002/mrd.22493

Cited by 3 publications

(3 citation statements)

References 178 publications

(174 reference statements)

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“…A study showed that not only the dysregulation of signaling pathways but also cytokines may trigger the formation of endometriosis [ 28 ]. The phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway is a pivotal intracellular signal transduction pathway, and the function of this pathway is the maintenance of the physiological functions [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing

et al. 2022

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Endometriosis is a common gynecological disease that affects approximately 5–10% of reproductive-aged women. However, the etiology and pathophysiology of endometriosis are currently unclear. The objective of this study was to identify a potential pathogenic gene of endometriosis using RNA sequencing (RNA-seq) analysis. Human endometrial stromal cells were isolated from four patients receiving surgical treatment for endometriosis during laparoscopic surgery, and RNA-seq was used to examine differentially expressed genes (DEGs) in eutopic and ectopic endometrial stromal cells. The functional significance of the differentially expressed genes was analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. A total of 1309 upregulated and 663 downregulated genes were identified through the analysis of the transcriptomes of eutopic and ectopic endometrial stromal cells. Furthermore, KEGG analysis indicated that these DEGs were mainly enriched in the PI3K-Akt signaling pathway, cytokine–cytokine receptor interaction, and MAPK signaling pathway. Our study identified differential gene expression in eutopic as compared to ectopic endometrial tissue stromal cells. We strongly believe that our findings can bring new insights into the underlying mechanisms of endometriosis. However, future research is necessary to clarify the roles of the identified genes.

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Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing

et al. 2022

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“…Although normal and ectopic endometrium are histologically similar, endometriotic lesions show a dysregulated response to ovarian steroids [ 70 , 71 ]. Oestrogen (E2) and progesterone are the master regulators of endometrial tissue.…”

Section: The Role Of Mtor Pathway In Endometriosis and Endometriosis-...mentioning

confidence: 99%

“…Over the past decade, cumulative evidence has implicated certain intracellular signalling pathways dysregulation in the molecular pathogenesis of endometriosis [ 71 ]. The mTOR pathway has been extensively studied as a potential pathway underpinning the initiation and development of endometriosis [ 75 ].…”

Section: The Role Of Mtor Pathway In Endometriosis and Endometriosis-...mentioning

confidence: 99%

The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review

Hablase,

Kyrou,

Randeva

et al. 2024

Cancers

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Ovarian cancer is an umbrella term covering a number of distinct subtypes. Endometrioid and clear-cell ovarian carcinoma are endometriosis-associated ovarian cancers (EAOCs) frequently arising from ectopic endometrium in the ovary. The mechanistic target of rapamycin (mTOR) is a crucial regulator of cellular homeostasis and is dysregulated in both endometriosis and endometriosis-associated ovarian cancer, potentially favouring carcinogenesis across a spectrum from benign disease with cancer-like characteristics, through an atypical phase, to frank malignancy. In this review, we focus on mTOR dysregulation in endometriosis and EAOCs, investigating cancer driver gene mutations and their potential interaction with the mTOR pathway. Additionally, we explore the complex pathogenesis of transformation, considering environmental, hormonal, and epigenetic factors. We then discuss postmenopausal endometriosis pathogenesis and propensity for malignant transformation. Finally, we summarize the current advancements in mTOR-targeted therapeutics for endometriosis and EAOCs.

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PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage

Madanes

Bilotas

Bastón

et al. 2019

Gynecological Endocrinology

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Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Cited by 3 publications

References 178 publications

Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing

Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing

The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review

PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage

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